{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:50:12Z","timestamp":1770709812243,"version":"3.49.0"},"reference-count":131,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese League Against Cancer\u2014Northern Branch","award":["LPCC-NRN2023-BVN"],"award-info":[{"award-number":["LPCC-NRN2023-BVN"]}]},{"name":"Portuguese League Against Cancer\u2014Northern Branch","award":["2020.08969.BD"],"award-info":[{"award-number":["2020.08969.BD"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT), co-financed by European Social Funds (FSE) and national funds of MCTES","doi-asserted-by":"publisher","award":["LPCC-NRN2023-BVN"],"award-info":[{"award-number":["LPCC-NRN2023-BVN"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT), co-financed by European Social Funds (FSE) and national funds of MCTES","doi-asserted-by":"publisher","award":["2020.08969.BD"],"award-info":[{"award-number":["2020.08969.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Gene variation linked to physiological functions is recognised to affect elite athletic performance by modulating training and competition-enabling behaviour. The fatty acid amide hydrolase (FAAH) has been investigated as a good candidate for drug targeting, and recently, its single-nucleotide polymorphism (SNP) rs324420 was reported to be associated with athletic performance. Given the implications, the biological pathways of this genetic polymorphism linked to elite athletic performance, considering sport type, psychological traits and sports injuries, need to be dissected. Thus, a narrative review of the literature concerning the biological mechanisms of this SNP was undertaken. In addition to its role in athletic performance, FAAH rs324420 is also involved in important mechanisms underlying human psychopathologies, including substance abuse and neural dysfunctions. However, cumulative evidence concerning the C385A variant is inconsistent. Therefore, validation studies considering homogeneous sports modalities are required to better define the role of this SNP in elite athletic performance and its impact on stress coping, pain regulation and inflammation control.<\/jats:p>","DOI":"10.3390\/genes14101946","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:43:49Z","timestamp":1697435029000},"page":"1946","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["FAAH rs324420 Polymorphism: Biological Pathways, Impact on Elite Athletic Performance and Insights for Sport Medicine"],"prefix":"10.3390","volume":"14","author":[{"given":"Hugo-Henrique","family":"Silva","sequence":"first","affiliation":[{"name":"ICBAS-School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal"},{"name":"Portuguese Ministry of Education, 1399-025 Lisbon, Portugal"},{"name":"Leix\u00f5es Sport Clube, Senior Female Volleyball Team, 4450-277 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-7757","authenticated-orcid":false,"given":"Val\u00e9ria","family":"Tavares","sequence":"additional","affiliation":[{"name":"ICBAS-School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal"},{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"},{"name":"FMUP-Faculty of Medicine, University of Porto, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-9904","authenticated-orcid":false,"given":"Beatriz","family":"Neto","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"},{"name":"LPCC, Research Department-Portuguese League Against Cancer (LPPC-NRN), 4200-172 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-4654","authenticated-orcid":false,"given":"F\u00e1tima","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"},{"name":"FP-I3ID, FP-BHS, CEBIMED and Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"CIIMAR\/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-8373","authenticated-orcid":false,"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"},{"name":"FMUP-Faculty of Medicine, University of Porto, 4200-072 Porto, Portugal"},{"name":"LPCC, Research Department-Portuguese League Against Cancer (LPPC-NRN), 4200-172 Porto, Portugal"},{"name":"FP-I3ID, FP-BHS, CEBIMED and Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"Pathology and Laboratory Medicine Department, Clinical Pathology SVIPO Porto Portuguese Oncology Institute of Porto, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-3119","authenticated-orcid":false,"given":"Maria-Raquel","family":"Silva","sequence":"additional","affiliation":[{"name":"FP-I3ID, FP-BHS, CEBIMED and Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"CIAS-Research Centre for Anthropology and Health-Human Biology, Health and Society, University of Coimbra, 3000-456 Coimbra, Portugal"},{"name":"CHRC-Comprehensive Health Research Centre, Nova Medical School, Nova University of Lisbon, 1150-090 Lisboa, Portugal"},{"name":"Scientific Committee of the Gymnastics Federation of Portugal, 1600-159 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"ref_1","first-page":"418","article-title":"Genomic profile in association with sport-type, sex, ethnicity, psychological traits and sports injuries of elite athletes","volume":"62","author":"Silva","year":"2022","journal-title":"J. Sports Med. Phys. Fit."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1080\/02640414.2019.1583156","article-title":"Association of serotoninergic pathway gene variants with elite athletic status in the Polish population","volume":"37","author":"Peplonska","year":"2019","journal-title":"J. Sports Sci."},{"key":"ref_3","first-page":"1420","article-title":"The elite athlete as a special risk traveller and the jet lag\u2019s effect: Lessons learned from the past and how to be prepared for the next Olympic Games 2020 Tokyo?","volume":"59","author":"Silva","year":"2019","journal-title":"J. Sports Med. Phys. Fit."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00431-016-2803-x","article-title":"Comparison of body composition and nutrients\u2019 deficiencies between Portuguese rink-hockey players","volume":"176","author":"Silva","year":"2017","journal-title":"Eur. J. Pediatr."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Silva, H.H., Tavares, V., Silva, M.-R.G., Neto, B.V., Cerqueira, F., and Medeiros, R. (2022). FAAH rs324420 Polymorphism Is Associated with Performance in Elite Rink-Hockey Players. Biology, 11.","DOI":"10.3390\/biology11071076"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Silva, H.H., Tavares, V., Silva, M.-R.G., Neto, B.V., Cerqueira, F., and Medeiros, R. (2023). Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players. Genes, 14.","DOI":"10.3390\/genes14061164"},{"key":"ref_7","first-page":"1383","article-title":"Effects of twelve weeks\u2019 aerobic training on motor cortex excitability","volume":"60","author":"Moscatelli","year":"2020","journal-title":"J. Sports Med. Phys. Fit."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000445240","article-title":"Genes and athletic performance: An Update","volume":"61","author":"Ahmetov","year":"2016","journal-title":"Med. Sport Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Petito, A., Altamura, M., Iuso, S., Padalino, F.A., Sessa, F., D\u2019Andrea, G., Margaglione, M., and Bellomo, A. (2016). The Relationship between Personality Traits, the 5HTT Polymorphisms, and the Occurrence of Anxiety and Depressive Symptoms in Elite Athletes. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156601"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1038\/s41386-020-0731-y","article-title":"Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: A [11C]CURB positron emission tomography study","volume":"45","author":"Kolla","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/acer.14552","article-title":"Association of the Fatty Acid Amide Hydrolase C385A Polymorphism With Alcohol Use Severity and Coping Motives in Heavy-Drinking Youth","volume":"45","author":"Best","year":"2021","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41398-020-0823-9","article-title":"Do AKT1, COMT and FAAH influence reports of acute cannabis intoxication experiences in patients with first episode psychosis, controls and young adult cannabis users?","volume":"10","author":"Hindocha","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1365-2036.2008.03910.x","article-title":"The role of fatty acid hydrolase gene variants in inflammatory bowel disease","volume":"29","author":"Storr","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/sms.12687","article-title":"Genetic variants associated with physical and mental characteristics of the elite athletes in the Polish population","volume":"27","author":"Peplonska","year":"2017","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/jmedgenet-2012-100972","article-title":"Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin","volume":"49","author":"Tejera","year":"2012","journal-title":"J. Med. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.biopsych.2022.11.022","article-title":"Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [11C]CURB in Heavy-Drinking Youth","volume":"94","author":"Best","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107545","DOI":"10.1016\/j.addbeh.2022.107545","article-title":"Genetic variation in fatty acid amide hydrolase (FAAH): Associations with early drinking and smoking behaviors","volume":"137","author":"Alsaafin","year":"2023","journal-title":"Addict. Behav."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.21873\/invivo.12935","article-title":"Association of Alcohol Use Disorder Risk with ADH1B, DRD2, FAAH, SLC39A8, GCKR, and PDYN Genetic Polymorphisms","volume":"36","author":"Legaki","year":"2022","journal-title":"In Vivo"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41386-020-0606-2","article-title":"Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: A positron emission tomography study with [C-11]CURB","volume":"45","author":"Best","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/adb.12491","article-title":"Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant","volume":"23","author":"Sloan","year":"2018","journal-title":"Addict. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00438-013-0809-x","article-title":"Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures","volume":"289","author":"Huertas","year":"2014","journal-title":"Mol. Genet. Genom."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00406-021-01367-4","article-title":"FAAH polymorphism (rs324420) modulates extinction recall in healthy humans: An fMRI study","volume":"272","author":"Spohrs","year":"2022","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.euroneuro.2016.03.003","article-title":"Genetically reduced FAAH activity may be a risk for the development of anxiety and depression in persons with repetitive childhood trauma","volume":"26","author":"Lazary","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.biopsych.2015.12.021","article-title":"Interactions Between Anandamide and Corticotropin-Releasing Factor Signaling Modulate Human Amygdala Function and Risk for Anxiety Disorders: An Imaging Genetics Strategy for Modeling Molecular Interactions","volume":"80","author":"Demers","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/jcbfm.2015.119","article-title":"The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB","volume":"35","author":"Boileau","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107100","DOI":"10.1016\/j.eplepsyres.2023.107100","article-title":"The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD","volume":"192","author":"Anvar","year":"2023","journal-title":"Epilepsy Res."},{"key":"ref_27","first-page":"33","article-title":"Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population","volume":"35","author":"Horcajadas","year":"2023","journal-title":"Adicciones"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Jacobson, M.R., Watts, J.J., Da Silva, T., Tyndale, R.F., Rusjan, P.M., Houle, S., Wilson, A.A., Ross, R.A., Boileau, I., and Mizrahi, R. (2021). Fatty acid amide hydrolase is lower in young cannabis users. Addict. Biol., 26.","DOI":"10.1111\/adb.12872"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Hindocha, C., Freeman, T.P., Schafer, G., Gardner, C., Bloomfield, M.A.P., Bramon, E., Morgan, C.J.A., and Curran, H.V. (2020). Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme. Addict. Biol., 25.","DOI":"10.1111\/adb.12762"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.drugalcdep.2016.06.021","article-title":"Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans","volume":"166","author":"Wilhelmsen","year":"2016","journal-title":"Drug Alcohol Depend."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.biopsych.2016.04.012","article-title":"Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging with the Novel Radiotracer [11C]CURB","volume":"80","author":"Boileau","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3109\/00952990.2016.1141913","article-title":"Dose-dependent cannabis use, depressive symptoms, and FAAH genotype predict sleep quality in emerging adults: A pilot study","volume":"42","author":"Maple","year":"2016","journal-title":"Am. J. Drug Alcohol Abus."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nicl.2015.03.024","article-title":"Poorer frontolimbic white matter integrity is associated with chronic cannabis use, FAAH genotype, and increased depressive and apathy symptoms in adolescents and young adults","volume":"8","author":"Shollenbarger","year":"2015","journal-title":"NeuroImage Clin."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/ajad.12788","article-title":"FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration","volume":"27","author":"Patel","year":"2018","journal-title":"Am. J. Addict."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/00952990.2019.1614596","article-title":"CNR1 and FAAH variation and affective states induced by marijuana smoking","volume":"45","author":"Palmer","year":"2019","journal-title":"Am. J. Drug Alcohol Abus."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/npp.2009.200","article-title":"Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues","volume":"35","author":"Filbey","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00213-008-1397-z","article-title":"Intermediate cannabis dependence phenotypes and the FAAH C385A variant: An exploratory analysis","volume":"203","author":"Schacht","year":"2009","journal-title":"Psychopharmacology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1111\/j.1360-0443.2008.02292.x","article-title":"Marijuana withdrawal and craving: Influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes","volume":"103","author":"Haughey","year":"2018","journal-title":"Addiction"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/ahg.12368","article-title":"FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence","volume":"84","author":"Zhang","year":"2020","journal-title":"Ann. Hum. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1017\/S0007114515005425","article-title":"Interactions between dietary oil treatments and genetic variants modulate fatty acid ethanolamides in plasma and body weight composition","volume":"115","author":"Pu","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.metabol.2010.07.007","article-title":"Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss after a hypocaloric diet","volume":"60","author":"Sagrado","year":"2011","journal-title":"Metab. Clin. Exp."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/JCP.0b013e3181e742c5","article-title":"Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G\/A CNR1 polymorphism is associated with antipsychotic-induced weight gain","volume":"30","author":"Monteleone","year":"2010","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1601-183X.2009.00518.x","article-title":"Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: Evidence for synergistic effects","volume":"8","author":"Monteleone","year":"2009","journal-title":"Genes Brain Behav."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"102922","DOI":"10.1016\/j.nicl.2021.102922","article-title":"The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD","volume":"33","author":"Crombie","year":"2022","journal-title":"NeuroImage Clin."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/da.23170","article-title":"Cannabinoid polymorphisms interact with plasma endocannabinoid levels to predict fear extinction learning","volume":"38","author":"Ney","year":"2021","journal-title":"Depress. Anxiety"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/jnr.24860","article-title":"A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults","volume":"100","author":"Zabik","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"E238","DOI":"10.1503\/jpn.200010","article-title":"Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: A combined positron emission tomography and magnetic resonance imaging study in healthy individuals","volume":"46","author":"Green","year":"2021","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41398-020-01177-7","article-title":"Fear extinction learning and anandamide: An fMRI study in healthy humans","volume":"11","author":"Spohrs","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/jgh.12513","article-title":"Association of cannabinoid type 1 receptor and fatty acid amide hydrolase genetic polymorphisms in Chinese patients with irritable bowel syndrome","volume":"29","author":"Jiang","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1053\/j.gastro.2011.07.036","article-title":"Pharmacogenetic trial of a cannabinoid agonist shows reduced fasting colonic motility in patients with nonconstipated irritable bowel syndrome","volume":"141","author":"Wong","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/dom.13504","article-title":"Genetic polymorphisms of the endocannabinoid system in obesity and diabetes","volume":"21","author":"Doris","year":"2019","journal-title":"Diabetes Obes. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"M\u00fcller, T.D., Br\u00f6nner, G., Wandolski, M., Carrie, J., Nguyen, T.T., Greene, B.H., Scherag, A., Grallert, H., Vogel, C.I., and Scherag, S. (2010). Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. BMC Med. Genet., 11.","DOI":"10.1186\/1471-2350-11-2"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000178157","article-title":"Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population","volume":"1","author":"Durand","year":"2008","journal-title":"Obes. Facts"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2217\/pgs-2016-0147","article-title":"Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children","volume":"18","author":"Chidambaran","year":"2017","journal-title":"Pharmacogenomics"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/tpj.2014.79","article-title":"Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects","volume":"15","author":"Sadhasivam","year":"2015","journal-title":"Pharmacogenom. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/npp.2009.166","article-title":"More aroused, less fatigued: Fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine","volume":"35","author":"Dlugos","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"535","DOI":"10.5507\/bp.2014.043","article-title":"Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels","volume":"159","author":"Chmelikova","year":"2015","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/00207144.2020.1682254","article-title":"Hypnotizability-related FAAH C385A polymorphism: Possible endocannabinoid contribution to suggestion-induced analgesia","volume":"68","author":"Presciuttini","year":"2020","journal-title":"Int. J. Clin. Exp. Hypn."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1097\/j.pain.0000000000001578","article-title":"OPRM1 rs1799971, COMT rs4680, and FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia","volume":"160","author":"Colloca","year":"2019","journal-title":"Pain"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/j.pain.0000000000000398","article-title":"Effect of endocannabinoid degradation on pain: Role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer","volume":"157","author":"Cajanus","year":"2016","journal-title":"Pain"},{"key":"ref_61","first-page":"637-e257","article-title":"Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity","volume":"23","author":"Camilleri","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1055\/s-0031-1291306","article-title":"The fatty acid amide hydrolase (FAAH) gene variant rs324420 AA\/AC is not associated with weight loss in a 1-year lifestyle intervention for obese children and adolescents","volume":"44","author":"Knoll","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.14309\/ajg.0000000000001805","article-title":"Cannabidiol for Functional Dyspepsia With Normal Gastric Emptying: A Randomized Controlled Trial","volume":"117","author":"Atieh","year":"2022","journal-title":"Am. J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2217\/pgs.09.122","article-title":"Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent","volume":"10","author":"Zhang","year":"2009","journal-title":"Pharmacogenomics"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"358-e169","DOI":"10.1111\/j.1365-2982.2011.01874.x","article-title":"Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea","volume":"24","author":"Wong","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00109-006-0139-0","article-title":"The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5801 whites","volume":"85","author":"Jensen","year":"2007","journal-title":"J. Mol. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1129946","DOI":"10.3389\/fncel.2023.1129946","article-title":"Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure","volume":"17","author":"Demaili","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI200419465","article-title":"The endogenous cannabinoid system protects against colonic inflammation","volume":"113","author":"Massa","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejphar.2003.08.101","article-title":"The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: Implications for neurological and psychiatric disorders","volume":"480","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/s41386-020-00888-1","article-title":"The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: A double-blind, randomized, placebo-controlled proof-of-concept study","volume":"46","author":"Schmidt","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/1570161033476583","article-title":"Cannabinoid system as a potential target for drug development in the treatment of cardiovascular disease","volume":"1","year":"2003","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-pharmtox-010716-104615","article-title":"Don\u2019t Worry, Be Happy: Endocannabinoids and Cannabis at the Intersection of Stress and Reward","volume":"57","author":"Volkow","year":"2017","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature00839","article-title":"The endogenous cannabinoid system controls extinction of aversive memories","volume":"418","author":"Marsicano","year":"2002","journal-title":"Nature"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1210\/er.2006-0006","article-title":"Jekyll and hyde: Two faces of cannabinoid signaling in male and female fertility","volume":"27","author":"Wang","year":"2006","journal-title":"Endocr. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2174\/187153008785700082","article-title":"Critical role of the endocannabinoid system in the regulation of food intake and energy metabolism, with phylogenetic, developmental, and pathophysiological implications","volume":"8","author":"Viveros","year":"2008","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/abbi.2001.2500","article-title":"Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes","volume":"393","author":"Maccarrone","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Pucci, M., Zaplatic, E., Micioni Di Bonaventura, M.V., Micioni Di Bonaventura, E., De Cristofaro, P., Maccarrone, M., Cifani, C., and D\u2019Addario, C. (2021). On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010398"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/mp.2012.72","article-title":"Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity","volume":"18","author":"MacPherson","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/physrev.00004.2003","article-title":"Role of endogenous cannabinoids in synaptic signaling","volume":"83","author":"Freund","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41398-022-02066-x","article-title":"Enhancing exposure therapy for posttraumatic stress disorder (PTSD): A randomized clinical trial of virtual reality and imaginal exposure with a cognitive enhancer","volume":"12","author":"Difede","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.ygeno.2019.07.024","article-title":"The first evidence of an association between a polymorphism in the endocannabinoid-degrading enzyme FAAH (FAAH rs2295633) with attention deficit hyperactivity disorder","volume":"112","author":"Ahmadalipour","year":"2020","journal-title":"Genomics"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.nutres.2020.09.001","article-title":"Comparison of endocannabinoids levels, FAAH gene polymorphisms, and appetite regulatory substances in women with and without binge eating disorder: A crosssectional study","volume":"83","author":"Yagin","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/npp.2015.166","article-title":"Neurobiological interactions between stress and the endocannabinoid system","volume":"41","author":"Morena","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"106520","DOI":"10.1016\/j.prostaglandins.2020.106520","article-title":"Understanding the possible role of endocannabinoid system in obesity","volume":"152","author":"Behl","year":"2021","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bcp.2018.07.009","article-title":"The endocannabinoid system in mental disorders: Evidence from human brain studies","volume":"157","author":"Muguruza","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-3-662-46450-2_7","article-title":"The role of the endocannabinoid system in pain","volume":"227","author":"Woodhams","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Melis, M. (2017). Endocannabinoids and Lipid Mediators in Brain Functions, Springer.","DOI":"10.1007\/978-3-319-57371-7"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.psyneuen.2008.01.004","article-title":"The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight\/obesity but not with binge eating disorder in overweight\/obese women","volume":"33","author":"Monteleone","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrn4036","article-title":"The endocannabinoid system in guarding against fear, anxiety and stress","volume":"16","author":"Lutz","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_90","unstructured":"(2023, August 24). Ensembl Database. Available online: https:\/\/www.ensembl.org\/index.html."},{"key":"ref_91","unstructured":"Ensembl Home (2023, August 24). rs324420 (SNP)\u2014Population Genetics\u2014Homo Sapiens\u2014Ensembl Genome Browser 89. Available online: http:\/\/www.ensembl.org\/Homo_sapiens\/Variation\/Population?db=core;r=1:46404589-46405589;v=rs324420;vdb=variation;vf=200953."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neuropharm.2017.06.015","article-title":"The cannabinoid system and pain","volume":"124","author":"Woodhams","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"603245","DOI":"10.3389\/fnbeh.2020.603245","article-title":"The Endocannabinoid System Activation as a Neural Network Desynchronizing Mediator for Seizure Suppression","volume":"14","author":"Medeiros","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ginevi\u010dien\u0117, V., Utkus, A., Pranckevi\u010dien\u0117, E., Semenova, E.A., Hall, E., and Ahmetov, I.I. (2022). Perspectives in Sports Genomics. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020298"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.psyneuen.2007.02.003","article-title":"Estrogen recruits the endocannabinoid system to modulate emotionality","volume":"32","author":"Hill","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1210\/en.2005-0610","article-title":"Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and \u03b3-aminobutyric acid inputs to hypothalamic magnocellular neurons","volume":"146","author":"Di","year":"2005","journal-title":"Endocrinology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1523\/JNEUROSCI.0496-11.2011","article-title":"Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response","volume":"31","author":"Hill","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1210\/en.2010-0285","article-title":"Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling","volume":"151","author":"Evanson","year":"2010","journal-title":"Endocrinology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/nn.3234","article-title":"Neurobiology of resilience","volume":"15","author":"Russo","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1038\/npp.2009.114","article-title":"Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic\u2013pituitary\u2013adrenal axis","volume":"34","author":"Hill","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1523\/JNEUROSCI.2737-14.2015","article-title":"Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety","volume":"35","author":"Gray","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biopsych.2008.10.047","article-title":"Divergent ef-fects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function","volume":"66","author":"Hariri","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6395","DOI":"10.1038\/ncomms7395","article-title":"FAAH genetic variation enhances fronto-amygdala function in mouse and human","volume":"6","author":"Dincheva","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1073\/pnas.1600013113","article-title":"Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species","volume":"113","author":"Gee","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1111\/acer.13210","article-title":"FAAH gene variation moderates stress response and symptom severity in patients with posttraumatic stress disorder and comorbid alcohol dependence","volume":"40","author":"Spagnolo","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/s41380-018-0215-1","article-title":"Protective effects of elevated anandamide on stress and fear-related behaviors: Translational evidence from humans and mice","volume":"25","author":"Mayo","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrd3673","article-title":"Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain","volume":"11","author":"Roques","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/nn.2632","article-title":"Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism","volume":"13","author":"Clapper","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/j.1532-2149.2012.00134.x","article-title":"Contribution of genetic variants to pain susceptibility in Parkinson disease","volume":"16","author":"Greenbaum","year":"2012","journal-title":"Eur. J. Pain"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.nbd.2013.04.018","article-title":"Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain","volume":"58","author":"Khasabova","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2174\/138945012800675786","article-title":"The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke","volume":"13","author":"Pini","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nature03658","article-title":"An endocannabinoid mechanism for stress-induced analgesia","volume":"435","author":"Hohmann","year":"2005","journal-title":"Nature"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1021\/acschemneuro.1c00192","article-title":"Selective fatty acid amide hydrolase inhibitors as potential novel antiepileptic agents","volume":"12","author":"Grillo","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1212\/WNL.0b013e3181a2e8f6","article-title":"Altered anandamide degradation in attention-deficit\/hyperactivity disorder","volume":"72","author":"Centonze","year":"2009","journal-title":"Neurology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000503831","article-title":"The epidemiology of epilepsy","volume":"54","author":"Beghi","year":"2020","journal-title":"Neuroepidemiology"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Buono, R.J., Bradfield, J.P., Wei, Z., Sperling, M.R., Dlugos, D.J., Privitera, M.D., French, J.A., Lo, W., Cossette, P., and Schachter, S.C. (2021). Genetic variation in PADI6-PADI4 on 1p36.13 is associated with common forms of human generalized epilepsy. Genes, 12.","DOI":"10.3390\/genes12091441"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S2215-0366(17)30167-0","article-title":"ADHD in children and young people: Prevalence, care pathways, and service provision","volume":"5","author":"Sayal","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.euroneuro.2017.05.005","article-title":"Cannabinoids in attention-deficit\/hyperactivity disorder: A randomised-controlled trial","volume":"27","author":"Cooper","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1080\/14737175.2017.1373019","article-title":"The potential role of cannabinoids in epilepsy treatment","volume":"17","author":"Leo","year":"2017","journal-title":"Expert Rev. Neurother."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Zou, S., and Kumar, U. (2018). Cannabinoid receptors and the endocannabinoid system: Signaling and function in the central nervous system. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030833"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/can.2020.0158","article-title":"Contribution of Fatty Acid Amide Hydrolase to Alcohol Use Disorder: A Systematic Review","volume":"6","author":"Niemela","year":"2021","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrn4004","article-title":"Endocannabinoid signalling in reward and addiction","volume":"16","author":"Parsons","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8394","DOI":"10.1073\/pnas.082235799","article-title":"A missense mutation in human fatty acid amide hydrolase associated with problem drug use","volume":"99","author":"Sipe","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Dongdem, J.T., Helegbe, G.K., Opare-Asamoah, K., Wezena, C.A., and Ocloo, A. (2022). Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro. BMC Pharmacol. Toxicol., 23.","DOI":"10.1186\/s40360-021-00539-1"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000235704","article-title":"Genetic testing of athletes","volume":"54","author":"Williams","year":"2009","journal-title":"Med. Sport Sci."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Papadimitriou, I.D., Lucia, A., Pitsiladis, Y.P., Pushkarev, V.P., Dyatlov, D.A., Orekhov, E.F., Artioli, G.G., Guilherme, J.P., Lancha, A.H., and Ginevi\u010dien\u0117, V. (2016). ACTN3 R577X and ACE I\/D gene variants influence performance in elite sprinters: A multi-cohort study. BMC Genom., 17.","DOI":"10.1186\/s12864-016-2462-3"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ghir.2020.01.002","article-title":"The combined frequencies of the IL-6 G-174C and IGFBP3 A-202C polymorphisms among swimmers and runners","volume":"51","author":"Meckel","year":"2020","journal-title":"Growth Horm. IGF Res."},{"key":"ref_128","first-page":"1885","article-title":"Genetic basis for the dominance of Israeli long-distance runners of Ethiopian origin","volume":"35","author":"Meckel","year":"2019","journal-title":"J. Strength Cond. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s00198-018-4610-x","article-title":"Genetic variation in Wnt\/\u03b2-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: A cross-section and longitudinal study","volume":"29","author":"Amorim","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Salles, J.I., Lopes, L.R., Duarte, M., Morrissey, D., Martins, M.B., Machado, D.E., Guimar\u00e3es, J., and Perini, J.A. (2018). Fc receptor-like 3 (-169T>C) polymorphism increases the risk of tendinopathy in volleyball athletes: A case control study. BMC Med. Genet., 19.","DOI":"10.1186\/s12881-018-0633-6"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s11332-019-00565-x","article-title":"Analysis of the Christiania stop in roller hockey players with and without previous groin pain: A prospective case series study","volume":"15","author":"Vitale","year":"2019","journal-title":"Sports Sci. Health"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/14\/10\/1946\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:07:38Z","timestamp":1760130458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/14\/10\/1946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":131,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["genes14101946"],"URL":"https:\/\/doi.org\/10.3390\/genes14101946","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,16]]}}}