{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:47:53Z","timestamp":1776077273521,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institute for Research and Innovation in Health Sciences","award":["UID\/BIM\/04293\/2019"],"award-info":[{"award-number":["UID\/BIM\/04293\/2019"]}]},{"name":"Institute for Research and Innovation in Health Sciences","award":["SFRH\/BD\/147650\/2019"],"award-info":[{"award-number":["SFRH\/BD\/147650\/2019"]}]},{"name":"Institute for Research and Innovation in Health Sciences","award":["NORTE-01-0145-FEDER-072678"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-072678"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UID\/BIM\/04293\/2019"],"award-info":[{"award-number":["UID\/BIM\/04293\/2019"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/147650\/2019"],"award-info":[{"award-number":["SFRH\/BD\/147650\/2019"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["NORTE-01-0145-FEDER-072678"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-072678"]}]},{"name":"The Porto Comprehensive Cancer Center","award":["UID\/BIM\/04293\/2019"],"award-info":[{"award-number":["UID\/BIM\/04293\/2019"]}]},{"name":"The Porto Comprehensive Cancer Center","award":["SFRH\/BD\/147650\/2019"],"award-info":[{"award-number":["SFRH\/BD\/147650\/2019"]}]},{"name":"The Porto Comprehensive Cancer Center","award":["NORTE-01-0145-FEDER-072678"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-072678"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Introduction: The repertoire of microRNAs (miRNAs) in thyroid carcinomas starts to be elucidated. Among differentiated thyroid carcinomas (DTCs), papillary thyroid carcinoma (PTC) is the most frequent. The assessment of miRNAs expression may contribute to refine the pre-surgical diagnosis in order to obtain a personalized and more effective treatment for patients. Aims: This study aims to evaluate (1) the miRNAs in a series of DTCs, and their association with the presence of selected genetic mutations in order to improve diagnosis and predict the biologic behavior of DTC\/PTC. (2) The reliability of molecular tests in Ultrasound-guided Fine Needle Aspiration Cytology (US-FNAC) for a more precise preoperative diagnosis. Material and Methods: This series includes 176 samples (98 cytology and 78 histology samples) obtained from 106 patients submitted to surgery, including 13 benign lesions (controls) and 93 DTCs (cases). The microRNA expression was assessed for miR-146b, miR-221, miR-222, and miR-15a through quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). The results were analyzed by the 2\u2212\u0394\u0394CT method, using miR16 as an endogenous control. Regarding PTC diagnosis, the discriminative ability of miRNAs expression was assessed by the area under the Receiver Operating Characteristic Curve (AUC). In PTCs, the association of miRNAs expression, clinicopathological features, and genetic mutations (BRAF, RAS, and TERTp) was evaluated. Results\/Discussion: All the analyzed miRNAs presented a tendency to be overexpressed in DTCs\/PTCs when compared with benign lesions, both in cytology and histology samples. In cytology, miRNAs expression levels were higher in malignant tumors than in benign tumors. In histology, the discriminative abilities regarding PTC diagnosis were as follows: miR-146b (AUC 0.94, 95% CI 0.87\u20131), miR-221 (AUC 0.79, 95% CI 0.68\u20130.9), miR-222 (AUC 0.76, 95% CI 0.63\u20130.89), and miR-15a (AUC 0.85, 95% CI 0.74\u20130.97). miR-146b showed 89% sensitivity (se) and 87% specificity (sp); miR-221 se = 68.4, sp = 90; miR-222 se = 73, sp = 70; and mi-R15a se = 72, sp = 80. MicroRNAs were associated with worst-prognosis clinicopathological characteristics in PTCs (p &lt; 0.05), particularly for miR-222. Our data reveal a significant association between higher expression levels of miR-146b, miR-221, and miR-222 in the presence of the BRAF mutation (p &lt; 0.001) and miR-146b (p = 0.016) and miR-221 (p = 0.010) with the RAS mutation, suggesting an interplay of these mutations with miRNAs expression. Despite this study having a relatively small sample size, overexpression of miRNAs in cytology may contribute to a more precise preoperative diagnosis. The miRNAs presented a good discriminative ability in PTC diagnosis. The association between the miRNAs expression profile and genetic alterations can be advantageous for an accurate diagnosis of DTCs\/PTCs in FNAC.<\/jats:p>","DOI":"10.3390\/genes15030389","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T11:37:22Z","timestamp":1711021042000},"page":"389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cyto-Histological Profile of MicroRNAs as Diagnostic Biomarkers in Differentiated Thyroid Carcinomas"],"prefix":"10.3390","volume":"15","author":[{"given":"Maria de Lurdes","family":"Matos","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Hospital Curry Cabral, Unidade Sa\u00fade Local S\u00e3o Jos\u00e9, Centro Cl\u00ednico e Acad\u00e9mico de Lisboa, 1050-166 Lisbon, Portugal"}]},{"given":"Mafalda","family":"Pinto","sequence":"additional","affiliation":[{"name":"Institute for Research & Innovation in Health (i3S), Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7421-8550","authenticated-orcid":false,"given":"Marta","family":"Alves","sequence":"additional","affiliation":[{"name":"Gabinete de Estat\u00edstica do Centro de Investiga\u00e7\u00e3o, Unidade Sa\u00fade Local S\u00e3o Jos\u00e9, Nova Medical School, Centro de Estat\u00edstica e Aplica\u00e7\u00f5es da Universidade de Lisboa (CEAUL), 1169-166 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3736-1323","authenticated-orcid":false,"given":"Sule","family":"Canberk","sequence":"additional","affiliation":[{"name":"Institute for Research & Innovation in Health (i3S), Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), 4200-135 Porto, Portugal"}]},{"given":"Ana","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0357-7350","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Bugalho","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital de Santa Maria, Unidade Sa\u00fade Local Santa Maria and Medical Faculty, University of Lisbon, 1069-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-8364","authenticated-orcid":false,"given":"Ana Lu\u00edsa","family":"Papoila","sequence":"additional","affiliation":[{"name":"Gabinete de Estat\u00edstica do Centro de Investiga\u00e7\u00e3o, Unidade Sa\u00fade Local S\u00e3o Jos\u00e9, Nova Medical School, Centro de Estat\u00edstica e Aplica\u00e7\u00f5es da Universidade de Lisboa (CEAUL), 1169-166 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-6998","authenticated-orcid":false,"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"Institute for Research & Innovation in Health (i3S), Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), 4200-135 Porto, Portugal"},{"name":"Department of Pathology, Medical Faculty, University of Porto, 4200-135 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"ref_1","unstructured":"Schlumberger, M., Pacini, F., and Tuttle, R.M. 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