{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:52:39Z","timestamp":1763747559831,"version":"build-2065373602"},"reference-count":111,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies.<\/jats:p>","DOI":"10.3390\/genes7090061","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T09:59:46Z","timestamp":1473242386000},"page":"61","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Telomerase Activation in Hematological Malignancies"],"prefix":"10.3390","volume":"7","author":[{"given":"Joana","family":"Ropio","sequence":"first","affiliation":[{"name":"Cutaneous Lymphoma Oncogenesis Team INSERM U1053 Bordeaux Research in Translational Oncology, Bordeaux University, Bordeaux 33076, France"},{"name":"Institute of Biomedical Sciences of Abel Salazar, University of Porto, Porto 4050-313, Portugal"},{"name":"Instituto de Investigac\u0327a\u0303o e Inovac\u0327a\u0303o em Sau\u0301de, Universidade do Porto, Porto 4200-135, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup)\u2014Cancer Biology, Rua Dr. Roberto Frias, s\/n, Porto 4200-465, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-0850","authenticated-orcid":false,"given":"Jean-Philippe","family":"Merlio","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Oncogenesis Team INSERM U1053 Bordeaux Research in Translational Oncology, Bordeaux University, Bordeaux 33076, France"},{"name":"Tumor Bank and Tumor Biology Laboratory, University Hospital Center Bordeaux, Pessac 33604, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-6998","authenticated-orcid":false,"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"Instituto de Investigac\u0327a\u0303o e Inovac\u0327a\u0303o em Sau\u0301de, Universidade do Porto, Porto 4200-135, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup)\u2014Cancer Biology, Rua Dr. Roberto Frias, s\/n, Porto 4200-465, Portugal"},{"name":"Department of Pathology and Oncology, Medical Faculty of Porto University, Porto 4200-319, Portugal"}]},{"given":"Edith","family":"Chevret","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Oncogenesis Team INSERM U1053 Bordeaux Research in Translational Oncology, Bordeaux University, Bordeaux 33076, France"}]}],"member":"1968","published-online":{"date-parts":[[2016,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/350569a0","article-title":"Structure and function of telomeres","volume":"350","author":"Blackburn","year":"1991","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.genet.41.110306.130350","article-title":"How shelterin protects mammalian telomeres","volume":"42","author":"Palm","year":"2008","journal-title":"Annu. 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