{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:01:33Z","timestamp":1773280893277,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER016867"],"award-info":[{"award-number":["POCI-01-0145-FEDER016867"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PO-CI-01-0145-FEDER-032358"],"award-info":[{"award-number":["PO-CI-01-0145-FEDER-032358"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/DTP-EPI\/7183\/2014"],"award-info":[{"award-number":["PTDC\/DTP-EPI\/7183\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04750\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0064\/2020"],"award-info":[{"award-number":["LA\/P\/0064\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-EPI\/6275\/2020"],"award-info":[{"award-number":["PTDC\/SAU-EPI\/6275\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-EPI\/32358\/2017"],"award-info":[{"award-number":["PTDC\/SAU-EPI\/32358\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Healthcare"],"abstract":"<jats:p>Anxiety and depression symptoms are frequent among patients with breast cancer (BCa) and may last after initial treatments. We aimed to identify five-year trajectories of anxiety and depression symptoms among women with BCa. Neuro-oncological complications of BCa (NEON-BC) cohort included 506 patients admitted at the Portuguese Institute of Oncology of Porto in 2012, who were evaluated with the Hospital Anxiety and Depression Scale before cancer treatment and after one, three, and five years (7.9% attrition rate). Mixed-effect models were used to model anxiety and depression scores over time and model-based clustering to identify the different trajectories. Three trajectories of anxiety symptoms were identified: (1) high scores at baseline and increasing over time (21.7%); (2) consistently low scores over time (63.6%); (3) mid-range scores at baseline, decreasing over time (14.6%). Three trajectories were identified for depression symptoms: (1) high scores at baseline and increasing over time (21.1%); (2) mid-range scores at baseline, which decreased afterward (58.7%); (3) consistently low levels over time (20.2%). Age, education, baseline, and one-year anxiety\/depression status predicted the worst five-year trajectories. These results show that assessing anxiety and depression symptoms before treatment and after one year may contribute to identifying the patients who could benefit the most from psychological support.<\/jats:p>","DOI":"10.3390\/healthcare10040661","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:33:03Z","timestamp":1648762383000},"page":"661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Trajectories of Anxiety and Depression Symptoms over Five Years since Breast Cancer Diagnosis: Results of the NEON-BC Prospective Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-7223","authenticated-orcid":false,"given":"Catarina","family":"Lopes","sequence":"first","affiliation":[{"name":"EPIUnit\u2014Instituto de Saude Publica, Universidade do Porto, Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Laboratorio para a Investiga\u00e7ao Integrativa e Translacional em Saude Populacional (ITR), Rua das Taipas, 135, 4050-600 Porto, Portugal"}]},{"given":"Milton","family":"Severo","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Saude Publica, Universidade do Porto, Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Laboratorio para a Investiga\u00e7ao Integrativa e Translacional em Saude Populacional (ITR), Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Departamento de Ciencias da Saude Publica e Forenses e Educa\u00e7ao Medica, Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-589X","authenticated-orcid":false,"given":"Filipa","family":"Fontes","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Saude Publica, Universidade do Porto, Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Laboratorio para a Investiga\u00e7ao Integrativa e Translacional em Saude Populacional (ITR), Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Instituto Portugues de Oncologia do Porto, R. Dr. Ant\u00f3nio Bernardino de Almeida 865, 4200-072 Porto, Portugal"}]},{"given":"Luisa","family":"Lopes-Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Saude Publica, Universidade do Porto, Rua das Taipas, 135, 4050-600 Porto, Portugal"}]},{"given":"Augusto","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto Portugues de Oncologia do Porto, R. Dr. Ant\u00f3nio Bernardino de Almeida 865, 4200-072 Porto, Portugal"}]},{"given":"Susana","family":"Pereira","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Saude Publica, Universidade do Porto, Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Laboratorio para a Investiga\u00e7ao Integrativa e Translacional em Saude Populacional (ITR), Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Instituto Portugues de Oncologia do Porto, R. Dr. Ant\u00f3nio Bernardino de Almeida 865, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-1430","authenticated-orcid":false,"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Saude Publica, Universidade do Porto, Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Laboratorio para a Investiga\u00e7ao Integrativa e Translacional em Saude Populacional (ITR), Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Departamento de Ciencias da Saude Publica e Forenses e Educa\u00e7ao Medica, Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-8999","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Saude Publica, Universidade do Porto, Rua das Taipas, 135, 4050-600 Porto, Portugal"},{"name":"Laboratorio para a Investiga\u00e7ao Integrativa e Translacional em Saude Populacional (ITR), Rua das Taipas, 135, 4050-600 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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