{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:59:36Z","timestamp":1762066776096,"version":"build-2065373602"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["#2019\/14115-0","#2019\/13094-0","#2019\/13188-4"],"award-info":[{"award-number":["#2019\/14115-0","#2019\/13094-0","#2019\/13188-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Healthcare"],"abstract":"<jats:p>Background: Because the consequences of the lifestyle changes in older adults associated with the social isolation imposed in response to the COVID-19 pandemic are not fully understood, here, we investigated the effects of one year of social isolation imposed by COVID-19 on the metabolic parameters and functional physical capacity of older women who regularly practiced physical exercises before the pandemic. Methods: Systemic lipid and protein profiles, estimated creatinine clearance (ECC), and functional physical capacity (FPC) were assessed before (January-February 2020) and 12 months after social isolation in 30 older women (mean age 73.77 \u00b1 6.22) who were engaged in a combined-exercise training program for at least 3 years before the COVID-19 pandemic. Results: In this group, we observed increased plasma levels of triglycerides and creatinine, an increase in the time necessary to perform gait speed and time-up-and-go tests, and reduced muscle strength assessed by the handgrip test and ECC post-COVID-19 pandemic relative to values recorded pre-pandemic. In addition, we observed significant correlations (both negative and positive) between anthropometric, some metabolic parameters, and physical tests. Conclusion: One year of interruption of physical exercise practice imposed in response to the COVID-19 pandemic significantly altered some systemic metabolic parameters and worsened ECC and FPC in older women.<\/jats:p>","DOI":"10.3390\/healthcare10091736","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T22:53:46Z","timestamp":1663023226000},"page":"1736","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Older Women Who Practiced Physical Exercises before the COVID-19 Pandemic Present Metabolic Alterations and Worsened Functional Physical Capacity after One Year of Social Isolation"],"prefix":"10.3390","volume":"10","author":[{"given":"Kizzy","family":"Cez\u00e1rio","sequence":"first","affiliation":[{"name":"Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), S\u00e3o Paulo 04829-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5822-7791","authenticated-orcid":false,"given":"Carlos Andr\u00e9 Freitas dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Discipline of Geriatrics and Gerontology, Department of Medicine, Paulista School of Medicine, Federal University of Sao Paulo (UNIFESP), S\u00e3o Paulo 04020-050, Brazil"},{"name":"Postgraduate Program in Translational Medicine, Department of Medicine, Paulista School of Medicine, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04023-062, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0647-0439","authenticated-orcid":false,"given":"Clineu de Mello Almada","family":"Filho","sequence":"additional","affiliation":[{"name":"Discipline of Geriatrics and Gerontology, Department of Medicine, Paulista School of Medicine, Federal University of Sao Paulo (UNIFESP), S\u00e3o Paulo 04020-050, Brazil"}]},{"given":"Gislene Rocha","family":"Amirato","sequence":"additional","affiliation":[{"name":"Mane Garrincha Sports Education Center, Sports Department of the Municipality of Sao Paulo (SEME), S\u00e3o Paulo 04039-034, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-4606","authenticated-orcid":false,"given":"Vit\u00f3ria da","family":"Paix\u00e3o","sequence":"additional","affiliation":[{"name":"ENT Research Lab., Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), S\u00e3o Paulo 04021-001, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6495-6931","authenticated-orcid":false,"given":"Ewin Barbosa","family":"Almeida","sequence":"additional","affiliation":[{"name":"ENT Research Lab., Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), S\u00e3o Paulo 04021-001, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5819-0474","authenticated-orcid":false,"given":"J\u00f4natas Bussador do","family":"Amaral","sequence":"additional","affiliation":[{"name":"ENT Research Lab., Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), S\u00e3o Paulo 04021-001, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-7021","authenticated-orcid":false,"given":"Adriana","family":"Caldo-Silva","sequence":"additional","affiliation":[{"name":"Faculty of Sports Sciences and Physical Education\u2014(FCDEF-UC), University of Coimbra, 3040-248 Coimbra, Portugal"},{"name":"Research Centre for Sport and Physical Activity, CIDAF-FCDEF-UC, 3040-248 Coimbra, Portugal"}]},{"given":"Nuno","family":"Pimenta","sequence":"additional","affiliation":[{"name":"School of Social Sciences, Education and Sport, Polytechnic Institute of Maia, 4475-690 Maia, Portugal"},{"name":"N2i, Research Nucleus, Polytechnic Institute of Maia, 4475-690 Maia, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6522-7594","authenticated-orcid":false,"given":"Ant\u00f3nio Rodrigues","family":"Sampaio","sequence":"additional","affiliation":[{"name":"School of Social Sciences, Education and Sport, Polytechnic Institute of Maia, 4475-690 Maia, Portugal"},{"name":"N2i, Research Nucleus, Polytechnic Institute of Maia, 4475-690 Maia, Portugal"}]},{"given":"Pedro","family":"Teques","sequence":"additional","affiliation":[{"name":"School of Social Sciences, Education and Sport, Polytechnic Institute of Maia, 4475-690 Maia, Portugal"},{"name":"N2i, Research Nucleus, Polytechnic Institute of Maia, 4475-690 Maia, Portugal"},{"name":"CIPER, Interdisciplinary Center for the Study of Human Performance, 1499-002 Lisbon, Portugal"}]},{"given":"Fernanda Monteiro","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), S\u00e3o Paulo 04829-300, Brazil"}]},{"given":"Carolina Nunes","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), S\u00e3o Paulo 04829-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-1416","authenticated-orcid":false,"given":"Andr\u00e9 Luis Lacerda","family":"Bachi","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), S\u00e3o Paulo 04829-300, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"ref_1","unstructured":"World Heath Organization (WHO) (2022, July 21). 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