{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:27:48Z","timestamp":1775471268359,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Healthcare"],"abstract":"<jats:p>Cancer is a leading cause of mortality and morbidity all over the world and the second major cause of death in Portugal. Dermatological side effects resulting from cancer treatment have a psychosocial impact on patients\u2019 lives, such as quality of life (QoL), body image, cognitive fusion and social inhibition. This systematic review aimed to explore and synthesize the psychosocial impact of dermatological side effects of cancer treatment, answering the following research objectives: (i) Do the dermatological side effects of the cancer treatment present any psychosocial impact for the patients? (ii) How does the psychosocial impact of the dermatological toxicities of the cancer treatment manifest in patients\u2019 lives? Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed and guided a systematic search through the PubMed, Cochrane Library and PyscNet databases. The considered studies correlate dermatological side effects of cancer treatments and their psychological\/psychosocial outcomes. The studies found were all published in peer-reviewed journals. The results obtained established that cancer treatment causes the most varied skin changes, consequently reducing self-esteem and QoL; disturbing body image; and contributing to cases of stress, depression and anxiety. There is still limited literature that profoundly investigates the experience of living with these skin toxicities. The development of research lines to improve knowledge in this field will allow for significant improvements in healthcare for patients undergoing cancer treatment who need to focus more on the psychosocial implications of skin toxicities. The novelty of this review lies in adding knowledge summarizing the psychosocial implications of dermatological side effects of cancer treatment to support healthcare providers in the development of integrative therapeutic strategies for these patients in their clinical practice.<\/jats:p>","DOI":"10.3390\/healthcare11192621","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T02:31:29Z","timestamp":1695695489000},"page":"2621","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Dermatological Side Effects of Cancer Treatment: Psychosocial Implications\u2014A Systematic Review of the Literature"],"prefix":"10.3390","volume":"11","author":[{"given":"Vera","family":"Almeida","sequence":"first","affiliation":[{"name":"UNIPRO\u2014Oral Pathology and Rehabilition Research Unit, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MedTech-Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Daniela","family":"Pires","sequence":"additional","affiliation":[{"name":"University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal"}]},{"given":"Marta","family":"Silva","sequence":"additional","affiliation":[{"name":"University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal"}]},{"given":"Maribel","family":"Teixeira","sequence":"additional","affiliation":[{"name":"1H-TOXRUN\u2014One Health Toxicology Research Unit, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-1660","authenticated-orcid":false,"given":"Ricardo Jo\u00e3o","family":"Teixeira","sequence":"additional","affiliation":[{"name":"REACH\u2014Mental Health Clinic, 4000-138 Porto, Portugal"},{"name":"CINEICC, Faculty of Psychology and Educational Sciences, University of Coimbra, 3004-531 Coimbra, Portugal"}]},{"given":"Andr\u00e9","family":"Louro","sequence":"additional","affiliation":[{"name":"REACH\u2014Mental Health Clinic, 4000-138 Porto, Portugal"},{"name":"RECI\u2014Research Unit in Education and Community Intervention, Instituto Piaget\u2014ISEIT\/Viseu, 1950-157 Viseu, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2198-6740","authenticated-orcid":false,"given":"Maria Alzira Pimenta","family":"Dinis","sequence":"additional","affiliation":[{"name":"UFP Energy, Environment and Health Research Unit (FP-ENAS), University Fernando Pessoa (UFP), Pra\u00e7a 9 de Abril 349, 4249-004 Porto, Portugal"},{"name":"Fernando Pessoa Research, Innovation and Development Institute (FP-I3ID), University Fernando Pessoa (UFP), Pra\u00e7a 9 de Abril 349, 4249-004 Porto, Portugal"}]},{"given":"Maria","family":"Ferreira","sequence":"additional","affiliation":[{"name":"University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3254-5326","authenticated-orcid":false,"given":"Ana","family":"Teixeira","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MedTech-Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"1H-TOXRUN\u2014One Health Toxicology Research Unit, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/1757975916686913","article-title":"Social determinants of cancer incidence and mortality around the world: An ecological study","volume":"26","author":"McDaniel","year":"2019","journal-title":"Glob. Health Promot."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Drobin, K., Marczyk, M., Halle, M., Danielsson, D., Papiez, A., Sangsuwan, T., Bendes, A., Hong, M.-G., Qundos, U., and Harms-Ringdahl, M. (2020). Molecular profiling for predictors of radiosensitivity in patients with breast or head-and-neck cancer. Cancers, 12.","DOI":"10.3390\/cancers12030753"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12094-008-0150-8","article-title":"Cardiac toxicity: Old and new issues in anti-cancer drugs","volume":"10","author":"Sereno","year":"2008","journal-title":"Clin. Transl. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/CIRCRESAHA.113.300218","article-title":"Emerging paradigms in cardiomyopathies associated with cancer therapies","volume":"113","author":"Ky","year":"2013","journal-title":"Circ. Res."},{"key":"ref_5","first-page":"115","article-title":"Ayurveda for chemo-radiotherapy induced side effects in cancer patients","volume":"8","author":"Metri","year":"2013","journal-title":"J. Stem Cells"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrc1970","article-title":"Mechanisms of cutaneous toxicities to EGFR inhibitors","volume":"6","author":"Lacouture","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zhang, X.J., Wang, A.P., Shi, T.Y., Zhang, J., Xu, H., Wang, D.Q., and Feng, L. (2019). The psychosocial adaptation of patients with skin disease: A scoping review. BMC Public Health, 19.","DOI":"10.1186\/s12889-019-7775-0"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000112795","article-title":"Impact and management of skin toxicity associated with anti-epidermal growth factor receptor therapy: Survey results","volume":"72","author":"Boone","year":"2008","journal-title":"Oncology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00520-007-0318-8","article-title":"Chemotherapy-induced dermatological toxicity: Frequencies and impact on quality of life in women\u2019s cancers. Results of a prospective study","volume":"16","author":"Hackbarth","year":"2008","journal-title":"Support. Care Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2133.2004.06026.x","article-title":"Acneiform eruption induced by epidermal growth factor receptor inhibitors in patients with solid tumours","volume":"151","author":"Jacot","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa053422","article-title":"Radiotherapy plus Cetuximab for Squamous\u2014Cell Carcinoma of the Head and Neck","volume":"354","author":"Bonner","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/annonc\/mdi279","article-title":"Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors","volume":"16","author":"Segaert","year":"2005","journal-title":"Ann. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0959-8049(09)70044-9","article-title":"Skin toxicities of targeted therapies","volume":"45","author":"Segaert","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1470-2045(14)71133-7","article-title":"Nail toxicities induced by systemic anticancer treatments","volume":"16","author":"Robert","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.revmed.2009.02.001","article-title":"Effets cutan\u00e9s des nouvelles mol\u00e9cules utilis\u00e9es en canc\u00e9rologie","volume":"30","author":"Mateus","year":"2009","journal-title":"Rev. Med. Interne"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1634\/theoncologist.12-5-610","article-title":"Epidermal Growth Factor Receptor Inhibitor\u2014Associated Cutaneous Toxicities: An Evolving Paradigm in Clinical Management","volume":"12","author":"Lynch","year":"2007","journal-title":"Oncologist"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/pon.3467","article-title":"Physical and psychosocial problems in cancer survivors beyond return to work: A systematic review","volume":"23","author":"Duijts","year":"2014","journal-title":"Psychooncology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/cncr.29939","article-title":"Caring for caregivers and patients: Research and clinical priorities for informal cancer caregiving","volume":"122","author":"Kent","year":"2016","journal-title":"Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00006842-200203000-00004","article-title":"History of psycho-oncology: Overcoming attitudinal and conceptual barriers","volume":"64","author":"Holland","year":"2002","journal-title":"Psychosom. Med."},{"key":"ref_20","first-page":"34","article-title":"The measure of distress","volume":"3","author":"Larouche","year":"2004","journal-title":"Contin. CARE Courses Dir."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1548-5315(11)70702-1","article-title":"Emotional distress in patients with cancer: The sixth vital sign","volume":"3","author":"Bultz","year":"2006","journal-title":"Community Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/ap.12165","article-title":"The Impact of Cancer on Psychological and Social Outcomes","volume":"51","author":"Costa","year":"2016","journal-title":"Aust. Psychol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0885-3924(02)00497-9","article-title":"Cancer pain and psychosocial factors: A critical review of the literature","volume":"24","author":"Zaza","year":"2002","journal-title":"J. Pain. Symptom Manag."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0033-3182(09)70835-7","article-title":"Cancer-Related Fatigue and Its Associations with Depression and Anxiety: A Systematic Review","volume":"50","author":"Brown","year":"2009","journal-title":"Psychosomatics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1002\/cncr.25090","article-title":"Effects of epidermal growth factor receptor inhibitor-induced dermatologic toxicities on quality of life","volume":"116","author":"Joshi","year":"2010","journal-title":"Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1468-3083.2009.03446.x","article-title":"Management of cutaneous side-effects of cetuximab therapy in patients with metastatic colorectal cancer","volume":"24","author":"Ocvirk","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2133.2009.09214.x","article-title":"Cutaneous side-effects in patients on long-term treatment with epidermal growth factor receptor inhibitors","volume":"161","author":"Osio","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/bjc.1997.507","article-title":"Patient perceptions of the side-effects of chemotherapy: The influence of 5HT3 antagonists","volume":"76","author":"Schmitz","year":"1997","journal-title":"Br. J. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/oxfordjournals.annonc.a010548","article-title":"On the receiving end V: Patient perceptions of the side effects of cancer chemotherapy in 1993","volume":"7","author":"Griffin","year":"1996","journal-title":"Ann. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/0277-5379(90)90046-V","article-title":"Effect of peri-operative chemotherapy on the quality of life of patients with early breast cancer","volume":"26","author":"Kiebert","year":"1990","journal-title":"Eur. J. Cancer Clin. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jaad.2005.10.010","article-title":"Dermatologic side effects associated with the epidermal growth factor receptor inhibitors","volume":"55","author":"Agero","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/jamadermatol.2018.5071","article-title":"Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia","volume":"155","author":"Chan","year":"2019","journal-title":"JAMA Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.4143\/crt.2017.435","article-title":"The Impact of Skin Problems on the Quality of Life in Patients Treated with Anticancer Agents: A Cross-Sectional Study","volume":"50","author":"Lee","year":"2018","journal-title":"Cancer Res. Treat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00520-009-0656-9","article-title":"Psychological effects of cetuximab-induced cutaneous rash in advanced colorectal cancer patients","volume":"18","author":"Romito","year":"2010","journal-title":"Support. Care Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00520-003-0562-5","article-title":"Chemotherapy-induced alopecia: Psychosocial impact and therapeutic approaches","volume":"12","author":"Hesketh","year":"2004","journal-title":"Support. Care Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01262572","article-title":"Changes in self-concept and body image during alopecia induced cancer chemotherapy","volume":"5","author":"Manthey","year":"1997","journal-title":"Support. Care Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s40261-015-0373-8","article-title":"Impact of Skin Toxicities Associated with Targeted Cancer Therapies on Body Image: A Prospective Study","volume":"36","author":"Charles","year":"2016","journal-title":"Clin. Drug Investig."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"De Sanctis, V., Agolli, L., Visco, V., Monaco, F., Muni, R., Spagnoli, A., Campanella, B., Valeriani, M., Minniti, G., and Osti, M.F. (2014). Cytokines, fatigue, and cutaneous erythema in early stage breast cancer patients receiving adjuvant radiation therapy. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/523568"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/13548500701405509","article-title":"Body image issues in women with breast cancer","volume":"13","author":"Helms","year":"2008","journal-title":"Psychol. Health Med."},{"key":"ref_40","first-page":"42","article-title":"Effect of skin reactions on quality of life for elderly women with breast cancer receiving chemotherapy","volume":"17","year":"2021","journal-title":"Zagazig Nurs. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1177\/1078155220936341","article-title":"Management of skin adverse reactions in oncology","volume":"26","author":"Silva","year":"2020","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1470-2045(05)70243-6","article-title":"Cutaneous side-effects of kinase inhibitors and blocking antibodies","volume":"6","author":"Robert","year":"2005","journal-title":"Lancet Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11523-010-0162-5","article-title":"Tufted hair folliculitis in a woman treated with trastuzumab","volume":"5","author":"Rosman","year":"2010","journal-title":"Target. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1016\/j.ejca.2010.03.008","article-title":"Inter-observer agreement between dermatologists and oncologists in assessing dermatological toxicities in patients with metastatic colorectal cancer treated by cetuximab-based chemotherapies: A pilot comparative study","volume":"46","author":"Duffour","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.23937\/2643-4466\/1710018","article-title":"A review of the most common dermatologic conditions and their debilitating psychosocial impacts","volume":"3","author":"Mian","year":"2019","journal-title":"Int. Arch. Int. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000506627","article-title":"Anxiety, depression, and suicidal ideation amongst patients with facial dermatoses (acne, rosacea, perioral dermatitis, and folliculitis) in Lithuania","volume":"236","author":"Lukaviciute","year":"2020","journal-title":"Dermatology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e2023029","DOI":"10.5826\/dpc.1301a29","article-title":"The Psychosocial Impact of Chronic Facial Dermatoses in Adults","volume":"13","author":"Ozcan","year":"2023","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kelly, K.A., Balogh, E.A., Kaplan, S.G., and Feldman, S.R. (2021). Skin disease in children: Effects on quality of life, stigmatization, bullying, and suicide risk in pediatric acne, atopic dermatitis, and psoriasis patients. Children, 8.","DOI":"10.3390\/children8111057"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clindermatol.2011.11.006","article-title":"Suicide risk in skin disorders","volume":"31","author":"Picardi","year":"2013","journal-title":"Clin. Dermatol."}],"container-title":["Healthcare"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9032\/11\/19\/2621\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:57:50Z","timestamp":1760129870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9032\/11\/19\/2621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,25]]},"references-count":49,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["healthcare11192621"],"URL":"https:\/\/doi.org\/10.3390\/healthcare11192621","relation":{},"ISSN":["2227-9032"],"issn-type":[{"value":"2227-9032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,25]]}}}