{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:46:19Z","timestamp":1760143579735,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund (ERDF)","award":["CENTRO-01-0145-FEDER-023369 AGA@4life"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-023369 AGA@4life"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Healthcare"],"abstract":"<jats:p>In recent years, the world\u2019s aging population has increased, contributing to the development of age-related pathologies, which have been aggravated by physical inactivity and excessive fat intake. This study aimed to evaluate the effect of implementing a nutritional program (control group\u2014CG) combined with exercise (intervention group\u2014IG) on the inflammatory profile, MMPs, and TIMPs in a group of 34 elderly participants (IG, n = 18; CG, n = 16). Participants underwent a full multidisciplinary diagnostic evaluation (T0), with the gathering of clinical information and biochemical and hematological determinations being re-evaluated eight weeks later (T1). A diet manual was made, which provided a selection of different types of diets resulting from the nutritional needs of the different users at the center. The aerobic exercise consisted of two sessions per week with a total duration of 1 h. The laboratory evaluation was performed by slot blot. Statistical analysis included a paired sample t-test and Spearman\u2019s correlation coefficient. We observed that in the IG, there was a significant increase at T1 of TNF-\u03b1 (p &lt; 0.05) and MMP-2 (p &lt; 0.05), without changes in IL-6 and MMP-9, showing that the intervention did not cause an exacerbated inflammatory response in exercised elderly people. The intervention program implemented showed potential to contribute to better active aging strategies, taking advantage of the known benefits of exercise without inducing a harmful inflammatory response in elderly participants.<\/jats:p>","DOI":"10.3390\/healthcare12050509","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T04:23:10Z","timestamp":1708489390000},"page":"509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Laboratory Assessment of the Effects of AGA@4life Multidisciplinary Intervention on the Inflammatory Profile, MMPs, and TIMPs in a Geriatric Population"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4205-980X","authenticated-orcid":false,"given":"Ana Patr\u00edcia","family":"Louren\u00e7o","sequence":"first","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"given":"Catarina","family":"Freitas","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"given":"Maria Helena","family":"Tim\u00f3teo","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"given":"Maria","family":"Soares","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"given":"Jo\u00e3o Paulo","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Social and Human Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"given":"N\u00e1dia","family":"Os\u00f3rio","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"LABINSA\u00daDE\u2014Research Laboratory for Applied Health Sciences, Polytechnic Institute of Coimbra, Coimbra Health School, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-6648","authenticated-orcid":false,"given":"Ana","family":"Valado","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"LABINSA\u00daDE\u2014Research Laboratory for Applied Health Sciences, Polytechnic Institute of Coimbra, Coimbra Health School, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8785-7522","authenticated-orcid":false,"given":"Maria","family":"Trapali","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry, Biochemistry and Cosmetic Science, Department of Biomedical Medicine, University of West Attica, Ag. Spyridonos Str., 12243 Egaleo, Greece"}]},{"given":"Telmo","family":"Pereira","sequence":"additional","affiliation":[{"name":"LABINSA\u00daDE\u2014Research Laboratory for Applied Health Sciences, Polytechnic Institute of Coimbra, Coimbra Health School, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Clinical Physiology, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7844-0506","authenticated-orcid":false,"given":"Armando","family":"Caseiro","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"LABINSA\u00daDE\u2014Research Laboratory for Applied Health Sciences, Polytechnic Institute of Coimbra, Coimbra Health School, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Caseiro, A., Rocha, C., Silva, A.M., Ferreira, C., Silva, I., Clemente, M., Cipriano, I., Saraiva, M., Barreira, R., and Azenha, J. (2020). 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