{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:48:34Z","timestamp":1764859714331,"version":"build-2065373602"},"reference-count":68,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Funds by Foundation for Science and Technology (FCT)","award":["BIPD\/UTAD\/7\/2023","PRT\/BD\/154440\/2022","UIDB\/04045\/2020"],"award-info":[{"award-number":["BIPD\/UTAD\/7\/2023","PRT\/BD\/154440\/2022","UIDB\/04045\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Healthcare"],"abstract":"<jats:p>Background: Breast cancer treatments often cause serious side effects, but physical exercise has shown the potential to improve both the physical and psychological health outcomes of survivors. This review and meta-analysis aimed to synthesize and analyze the scientific evidence on the effectiveness of concurrent training on physical, psychological, and biomarkers variables on breast cancer survivors.; Methods: A systematic review and meta-analysis was registered in PROSPERO (CRD42024571851). The ISI Web of Science, PubMed, and Scopus databases were searched. The methodological quality of all the included studies was assessed using the Cochrane risk of bias tool. This review included 14 articles that met the inclusion criteria on the effect of concurrent training on breast cancer survivors. Results: The results of the meta-analysis on body composition revealed a significant overall effect on body mass (effect size [ES] = \u22122.23; 95% CI: \u22124.16, \u22120.29) and body mass index (ES = \u22120.66; 95% CI: \u22121.32, 0.01). In contrast, no significant differences were shown in the % fat mass (ES = \u22122.63; 95% CI: \u22125.58, 0.33). Strength significantly improved after simultaneous training (ES = 4.93; 95% CI: 1.94, 7.92). In addition, cardiorespiratory fitness (maximum oxygen consumption) showed significant improvements after simultaneous training (ES = 3.03; 95% CI: 1.88, 4.19). Conclusions: The research shows that concurrent training, including strength and aerobic exercises, promotes significant improvements in body mass, body mass index, muscle strength, and cardiorespiratory fitness. However, the effectiveness of the training depends on the intensity, duration and frequency of the exercise, as well as the individualization of the programs.<\/jats:p>","DOI":"10.3390\/healthcare13010033","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T12:37:19Z","timestamp":1735648639000},"page":"33","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Concurrent Training in Breast Cancer Survivors: A Systematic Review and Meta-Analysis of Physical, Psychological, and Biomarker Variables"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5011-4709","authenticated-orcid":false,"given":"Ricardo","family":"Madeira","sequence":"first","affiliation":[{"name":"Department of Sport Sciences, University of Beira Interior, Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"},{"name":"Health Sciences Research Center, University of Beira Interior (CICS-UBI), Av. Infante D. Henrique, 6201-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-2577","authenticated-orcid":false,"given":"Dulce","family":"Esteves","sequence":"additional","affiliation":[{"name":"Department of Sport Sciences, University of Beira Interior, Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0794-6993","authenticated-orcid":false,"given":"Adriana","family":"Maia","sequence":"additional","affiliation":[{"name":"Department of Sport Sciences, University of Beira Interior, Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"}]},{"given":"Ana R.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Sport Sciences, University of Beira Interior, Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-0616","authenticated-orcid":false,"given":"Diogo L.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Sport Sciences, University of Beira Interior, Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9283-312X","authenticated-orcid":false,"given":"Henrique P.","family":"Neiva","sequence":"additional","affiliation":[{"name":"Department of Sport Sciences, University of Beira Interior, Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), Convento de Santo Ant\u00f3nio, 6201-001 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1139\/H07-074","article-title":"Exercise, aging, and cancer","volume":"32","author":"Courneya","year":"2007","journal-title":"Appl. Physiol. Nutr. Metab. Physiol. Appl. Nutr. Et Metab."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1080\/13548506.2019.1597978","article-title":"Health-related quality of life and physical fitness in breast cancer patients: The impact of a supervised physical exercise program in women with no exercise experience","volume":"24","author":"Antunes","year":"2019","journal-title":"Psychol. Health Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10549-020-06092-5","article-title":"T Body composition and breast cancer risk and treatment: Mechanisms and impact","volume":"186","author":"Iwase","year":"2021","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1503\/cmaj.051073","article-title":"Effects of exercise on breast cancer patients and survivors: A systematic review and meta-analysis","volume":"175","author":"McNeely","year":"2006","journal-title":"CMAJ Can. Med. Assoc. J. J. De L\u2019association Medicale Can."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1249\/MSS.0000000000001937","article-title":"Physical Activity in Cancer Prevention and Survival: A Systematic Review","volume":"51","author":"McTiernan","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.breast.2019.02.001","article-title":"Physical activity in breast cancer survivors: A systematic review and meta-analysis on overall and breast cancer survival","volume":"44","author":"Spei","year":"2019","journal-title":"Breast"},{"key":"ref_8","first-page":"16","article-title":"Global Cancer Incidence and Mortality Rates and Trends-An Update","volume":"25","author":"Torre","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev. A Publ. Am. Assoc. Cancer Res. Cosponsored By Am. Soc. Prev. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10549-014-3162-9","article-title":"Safety and efficacy of progressive resistance training in breast cancer: A systematic review and meta-analysis","volume":"148","author":"Cheema","year":"2014","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40279-022-01759-z","article-title":"Resistance Training for Patients with Cancer: A Conceptual Framework for Maximizing Strength, Power, Functional Mobility, and Body Composition to Optimize Health and Outcomes","volume":"53","author":"Champ","year":"2023","journal-title":"Sports Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/02841860701418838","article-title":"High-intensity strength training improves quality of life in cancer survivors","volume":"46","author":"Vreugdenhil","year":"2007","journal-title":"Acta Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e17625","DOI":"10.1097\/MD.0000000000017625","article-title":"Effects of a 12-week resistance and aerobic exercise program on muscular strength and quality of life in breast cancer survivors: Study protocol for the EFICAN randomized controlled trial","volume":"98","year":"2019","journal-title":"Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ctim.2017.11.023","article-title":"Effects of combined and resistance training on the inflammatory profile in breast cancer survivors: A systematic review","volume":"36","author":"Puga","year":"2018","journal-title":"Complement. Ther. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jsams.2019.05.003","article-title":"The Exercise and Sports Science Australia position statement: Exercise medicine in cancer management","volume":"22","author":"Hayes","year":"2019","journal-title":"J. Sci. Med. Sport"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Meneses-Ech\u00e1vez, J.F., Gonz\u00e1lez-Jim\u00e9nez, E., and Ram\u00edrez-V\u00e9lez, R. (2015). Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: A systematic review and meta-analysis. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1069-4"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e000432","DOI":"10.1161\/JAHA.113.000432","article-title":"Cardiorespiratory fitness in breast cancer patients: A call for normative values","volume":"3","author":"Peel","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ijc.33508","article-title":"The association of prediagnostic circulating levels of cardiometabolic markers, testosterone and sex hormone-binding globulin with risk of breast cancer among normal weight postmenopausal women in the UK Biobank","volume":"149","author":"Arthur","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Venturelli, E., Orenti, A., Fabricio, A.S.C., Garrone, G., Agresti, R., Paolini, B., Bonini, C., Gion, M., Berrino, F., and Desmedt, C. (2018). Observational study on the prognostic value of testosterone and adiposity in postmenopausal estrogen receptor positive breast cancer patients. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4558-4"},{"key":"ref_19","first-page":"353","article-title":"Exercise after breast cancer treatment: Current perspectives","volume":"7","author":"Orozco","year":"2015","journal-title":"Breast Cancer (Dove Med. Press)"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1001\/jama.293.20.2479","article-title":"Physical activity and survival after breast cancer diagnosis","volume":"293","author":"Holmes","year":"2005","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1200\/JCO.2006.08.2024","article-title":"Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: A multicenter randomized controlled trial","volume":"25","author":"Courneya","year":"2007","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1055\/s-0029-1225330","article-title":"Resistance training in cancer survivors: A systematic review","volume":"30","author":"Schep","year":"2009","journal-title":"Int. J. Sports Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s12282-022-01347-z","article-title":"Impact of exercise interventions on physical fitness in breast cancer patients and survivors: A systematic review","volume":"29","author":"Ficarra","year":"2022","journal-title":"Breast Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3322\/caac.21405","article-title":"Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention","volume":"67","author":"Friedman","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Monta\u00f1o-Rojas, L.S., Romero-P\u00e9rez, E.M., Medina-P\u00e9rez, C., Reguera-Garc\u00eda, M.M., and de Paz, J.A. (2020). Resistance Training in Breast Cancer Survivors: A Systematic Review of Exercise Programs. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17186511"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2165\/11539690-000000000-00000","article-title":"Strategies to optimize concurrent training of strength and aerobic fitness for rowing and canoeing","volume":"41","author":"Izquierdo","year":"2011","journal-title":"Sports Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.puhe.2016.03.028","article-title":"Effects of concurrent aerobic and strength training on breast cancer survivors: A pilot study","volume":"136","author":"Minganti","year":"2016","journal-title":"Public Health"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13058-018-1051-6","article-title":"Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: A randomized controlled trial","volume":"20","author":"Courneya","year":"2018","journal-title":"Breast Cancer Res. BCR"},{"key":"ref_29","first-page":"790","article-title":"Concurrent Exercise Interventions in Breast Cancer Survivors with Cancer-related fatigue","volume":"41","author":"Pagola","year":"2020","journal-title":"Int. J. Sports Med."},{"key":"ref_30","unstructured":"Madeira, R., Neiva, H.P., Maia, A., and Esteves, D. (2023). The Effect of Concurrent Training on Cancer Survivors: An Update of the Scientific Evidence. Physiother. Sports Inj., 1."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e588","DOI":"10.1093\/pubmed\/fdac036","article-title":"Strengthening systematic reviews in public health: Guidance in the Cochrane Handbook for Systematic Reviews of Interventions","volume":"44","author":"Cumpston","year":"2022","journal-title":"J. Public Health"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1037\/0021-9010.91.3.594","article-title":"Implications of direct and indirect range restriction for meta-analysis methods and findings","volume":"91","author":"Hunter","year":"2006","journal-title":"J. Appl. Psychol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e076335","DOI":"10.1136\/bmj-2023-076335","article-title":"Updated recommendations for the Cochrane rapid review methods guidance for rapid reviews of effectiveness","volume":"384","author":"Garritty","year":"2024","journal-title":"BMJ"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Cohen, J. (2013). Statistical Power Analysis for the Behavioral Sciences, Routledge.","DOI":"10.4324\/9780203771587"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s40279-022-01769-x","article-title":"Manipulating the Resistance Training Volume in Middle-Aged and Older Adults: A Systematic Review with Meta-Analysis of the Effects on Muscle Strength and Size, Muscle Quality, and Functional Capacity","volume":"53","author":"Marques","year":"2023","journal-title":"Sports Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/jnci\/djt297","article-title":"Effects of exercise dose and type during breast cancer chemotherapy: Multicenter randomized trial","volume":"105","author":"Courneya","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1080\/09638288.2018.1460877","article-title":"Comparing exercise responses to aerobic plus resistance training between postmenopausal breast cancer survivors undergoing aromatase inhibitor therapy and healthy women","volume":"41","author":"Viezel","year":"2019","journal-title":"Disabil. Rehabil."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"zsab111","DOI":"10.1093\/sleep\/zsab111","article-title":"Aerobic and resistance exercise improve patient-reported sleep quality and is associated with cardiometabolic biomarkers in Hispanic and non-Hispanic breast cancer survivors who are overweight or obese: Results from a secondary analysis","volume":"44","author":"Courneya","year":"2021","journal-title":"Sleep"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1200\/JCO.2017.75.7526","article-title":"Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenia Obesity, and Circulating Biomarkers in Overweight 4or obese survivors of breast cancer: A randomized controlled trial","volume":"36","author":"Courneya","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/s-2006-924348","article-title":"Effects of detraining on the functional capacity of previously trained breast cancer survivors","volume":"28","author":"Herrero","year":"2007","journal-title":"Int. J. Sports Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e13231","DOI":"10.1111\/ecc.13231","article-title":"Circuit resistance training and cardiovascular health in breast cancer survivors","volume":"29","author":"Jones","year":"2020","journal-title":"Eur. J. Cancer Care"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ijc.32493","article-title":"Effects of exercise dose and type during breast cancer chemotherapy on longer-term patient-reported outcomes and health-related fitness: A randomized controlled trial","volume":"146","author":"An","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s11764-019-00747-z","article-title":"High-intensity exercise during chemotherapy induces beneficial effects 12 months into breast cancer survivorship","volume":"13","author":"Mijwel","year":"2019","journal-title":"J. Cancer Surviv. Res. Pract."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"599","DOI":"10.12965\/jer.1735048.524","article-title":"Short-term combined exercise training improves cardiorespiratory fitness and autonomic modulation in cancer patients receiving adjuvant therapy","volume":"13","author":"Mostarda","year":"2017","journal-title":"J. Exerc. Rehabil."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12282-018-0889-x","article-title":"Effects of a combined exercise plus diet program on cardiorespiratory fitness of breast cancer patients","volume":"26","author":"Okumatsu","year":"2019","journal-title":"Breast Cancer"},{"key":"ref_46","first-page":"242","article-title":"Effect of Combined Training on Body Image, Body Composition and Functional Capacity in Patients with Breast Cancer: Controlled Clinical Trial. Efeito do treinamento combinado na imagem corporal, composi\u00e7\u00e3o corporal e capacidade funcional em pacientes com c\u00e2ncer de mama: Ensaio cl\u00ednico controlado","volume":"45","author":"Reis","year":"2023","journal-title":"Rev. Bras. De Ginecol. E Obstet. Rev. Da Fed. Bras. Das Soc. De Ginecol. E Obstet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12955-018-0882-2","article-title":"Effect of exercise on pain and functional capacity in breast cancer patients","volume":"16","author":"Reis","year":"2018","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Thivat, E., Th\u00e9rondel, S., Lapirot, O., Abial, C., Gimbergues, P., Gad\u00e9a, E., Planchat, E., Kwiatkowski, F., Mouret-Reunier, M.A., and Chollet, P. (2010). Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse. BMC Cancer, 10.","DOI":"10.1186\/1471-2407-10-648"},{"key":"ref_49","first-page":"1370","article-title":"Weight, weight gain, and survival after breast cancer diagnosis","volume":"23","author":"Kroenke","year":"2005","journal-title":"BMC Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1249\/MSS.0000000000001764","article-title":"Resistance Training Volume Enhances Muscle Hypertrophy but Not Strength in Trained Men","volume":"51","author":"Schoenfeld","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/eurjpc\/zwab007","article-title":"Exercise intensity assessment and prescription in cardiovascular rehabilitation and beyond: Why and how: A position statement from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology","volume":"29","author":"Hansen","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1519\/JSC.0b013e318234e84c","article-title":"Consistency of the Counting Talk Test for Exercise Prescription","volume":"26","author":"Loose","year":"2012","journal-title":"J. Strength Cond. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Ramos-Campo, D.J., Andreu, C.L., Mart\u00ednez-Rodr\u00edguez, A., and Rubio-Arias, J.\u00c1. (2021). Effects of Resistance Circuit-Based Training on Body Composition, Strength and Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis. Biology, 10.","DOI":"10.3390\/biology10050377"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jcsm.12165","article-title":"Muscle strength in breast cancer patients receiving different treatment regimes","volume":"8","author":"Klassen","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1007\/s00520-020-05407-y","article-title":"Exercise intensity prescription in cancer survivors: Ventilatory and lactate thresholds are useful submaximal alternatives to VO2peak","volume":"28","author":"Schneider","year":"2020","journal-title":"Support Care Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Meyer, D., Pastor-Villaescusa, B., Michel, S., Hauner, H., and Hauner, D. (2022). Associations between circulating obesity-related biomarkers and prognosis in female breast cancer survivors: A systematic review of observational data in women enrolled in lifestyle intervention trials. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-10274-3"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e32391","DOI":"10.1097\/MD.0000000000032391","article-title":"Aerobic exercise combined with resistance exercise training improves cardiopulmonary function and blood lipid of patients with breast cancer: A systematic review and meta-analysis","volume":"101","author":"Kong","year":"2022","journal-title":"Medicine"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Maginador, G., Lixandr\u00e3o, M.E., Bortolozo, H.I., Vechin, F.C., Sarian, L.O., Derchain, S., Telles, G.D., Zopf, E., Ugrinowitsch, C., and Concei\u00e7\u00e3o, M.S. (2020). Aerobic Exercise-Induced Changes in Cardiorespiratory Fitness in Breast Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis. Cancers, 12.","DOI":"10.3390\/cancers12082240"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1249\/MSS.0000000000002828","article-title":"Physical Fitness and Chemotherapy Tolerance in Patients with Early-Stage Breast Cancer","volume":"54","author":"Groen","year":"2022","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.31557\/APJCP.2019.20.11.3197","article-title":"Benefits of Aerobic Exercise for Breast Cancer Survivors: A Systematic Review of Randomized Controlled Trials","volume":"20","author":"Bekhet","year":"2019","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"101290","DOI":"10.1016\/j.ctcp.2020.101290","article-title":"Effects of aerobic, resistance, and mixed exercises on quality of life in patients with cancer: A systematic review and meta-analysis","volume":"42","author":"Fukushima","year":"2021","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/cncr.21671","article-title":"Fatigue in long-term breast carcinoma survivors: A longitudinal investigation","volume":"106","author":"Bower","year":"2006","journal-title":"Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/pon.3594","article-title":"Inflammation and psychosocial factors mediate exercise effects on sleep quality in breast cancer survivors: Pilot randomized controlled trial","volume":"24","author":"Rogers","year":"2015","journal-title":"Psycho-Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13058-018-1009-8","article-title":"Effect of exercise and\/or reduced calorie dietary interventions on breast cancer-related endogenous sex hormones in healthy postmenopausal women","volume":"20","author":"May","year":"2018","journal-title":"Breast Cancer Res. BCR"},{"key":"ref_65","first-page":"355","article-title":"Effects of Exercise on Insulin, IGF Axis, Adipocytokines, and Inflammatory Markers in Breast Cancer Survivors: A Systematic Review and Meta-analysis","volume":"26","author":"Kang","year":"2017","journal-title":"Cancer Epidemiol. Biomark. Prev. A Publ. Am. Assoc. Cancer Res. Cosponsored By Am. Soc. Prev. Oncol."},{"key":"ref_66","first-page":"1009","article-title":"The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis","volume":"25","author":"Elkins","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev. A Publ. Am. Assoc. Cancer Res. Cosponsored By Am. Soc. Prev. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/bjsports-2017-098970","article-title":"Effects of short-term, medium-term and long-term resistance exercise training on cardiometabolic health outcomes in adults: Systematic review with meta-analysis","volume":"54","author":"Ashton","year":"2020","journal-title":"Br. J. Sports Med."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Saco-Ledo, G., Valenzuela, P.L., Ruilope, L.M., and Lucia, A. (2022). Physical exercise in resistant hypertension: A systematic review and meta-analysis of randomized controlled trials. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.893811"}],"container-title":["Healthcare"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9032\/13\/1\/33\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:01:44Z","timestamp":1760115704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9032\/13\/1\/33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["healthcare13010033"],"URL":"https:\/\/doi.org\/10.3390\/healthcare13010033","relation":{},"ISSN":["2227-9032"],"issn-type":[{"type":"electronic","value":"2227-9032"}],"subject":[],"published":{"date-parts":[[2024,12,27]]}}}