{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T13:39:56Z","timestamp":1775050796041,"version":"3.50.1"},"reference-count":106,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Healthcare"],"abstract":"<jats:p>Psychological distress is an extremely relevant phenomenon in cancer patients due to its high prevalence, especially when cancer diagnoses are increasingly frequent. It is estimated that only one-third of patients with clinically significant levels of distress are referred to mental health services. To reinforce this point, most health centers lack the resources for distress screening. Background\/Objectives: This study aims to systematically gather and critique information relevant to the operationalization of distress, as well as the instruments used to assess it. Methods: The data included in this systematic review were published after 2014 and collected through the meta-database EBSCO and the following databases: PsycArticles, PubMED, and SCOPUS. Results: A total of 1028 references were imported, and 54 duplicate articles were excluded. Of the 974 references, 934 were excluded because they had titles, keywords, or abstracts that were incompatible with the research objectives. Finally, of the 40 articles obtained, 3 were excluded due to the inclusion of cancer survivors, 1 for including a non-oncological sample, and 9 for not expressing a focus on distress, resulting in a total of 27 articles included in this systematic review. Conclusions: The field of psycho-oncology needs to improve the understanding and assessment of distress in cancer patients. The lack of a holistic and homogeneous vision, as well as the use of reductionist instruments are common problems. A more complete understanding of distress, especially its effective evaluation, and better communication with other health professionals and their patients concerning this health issue are needed.<\/jats:p>","DOI":"10.3390\/healthcare13161976","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T15:51:02Z","timestamp":1755013862000},"page":"1976","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Defining and Assessing Distress in Oncology Patients: A Systematic Review of the Literature"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6933-6963","authenticated-orcid":false,"given":"Tiago","family":"Lima","sequence":"first","affiliation":[{"name":"Department of Psychology and Education, University of Beira Interior, 6200-209 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8919-0378","authenticated-orcid":false,"given":"Ana","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Psychology and Education, University of Beira Interior, 6200-209 Covilh\u00e3, Portugal"},{"name":"RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, 6200-209 Covilh\u00e3, Portugal"},{"name":"CIDESD Center for Research in Sport, Health and Human Development, 5000-801 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-5865","authenticated-orcid":false,"given":"Paula","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Psychology and Education, University of Beira Interior, 6200-209 Covilh\u00e3, Portugal"},{"name":"RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, 6200-209 Covilh\u00e3, Portugal"},{"name":"CIDESD Center for Research in Sport, Health and Human Development, 5000-801 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-1660","authenticated-orcid":false,"given":"Ricardo Jo\u00e3o","family":"Teixeira","sequence":"additional","affiliation":[{"name":"REACH\u2014Mental Health Clinic, 4000-138 Porto, Portugal"},{"name":"CINEICC, Faculty of Psychology and Education Sciences, University of Coimbra, 3004-531 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref_1","unstructured":"Holland, J.C., and Rowland, J.H. 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