{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T16:03:03Z","timestamp":1764691383500,"version":"3.46.0"},"reference-count":83,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Regional Ministry of Education, Culture, Universities and Employment of the Generalitat Valenciana, Spain","doi-asserted-by":"publisher","award":["CIAICO\/2023\/056"],"award-info":[{"award-number":["CIAICO\/2023\/056"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["CIACIF\/2021\/189"],"award-info":[{"award-number":["CIACIF\/2021\/189"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Healthcare"],"abstract":"<jats:p>Objectives: To examine three elastic band resistance training (EB-RT) modalities\u2014high-velocity (HVRT), accentuated eccentric (Aecc), and maximal strength (Max)\u2014on bone health, strength, redox-inflammatory profile, and neuroplasticity in sedentary older adults. Methods: Sixty-one participants (69.41 \u00b1 4.61 years) were randomly assigned to HVRT (n = 21), Aecc (n = 13), Max (n = 10), or passive controls (n = 17). Training was conducted three times a week for 16 weeks. Sessions included four sets of alternating upper- and lower-limb EB exercises, with intensity guided by the OMNI\u2013RES EB scale. HVRT emphasized explosive concentric actions [~70% one-repetition maximum (1RM); 3\u20134 rating of perceived exertion in the first repetition (RPE-1)]. Aecc performed 5 s eccentric overload [&gt;100% 1RM; 7\u20138 RPE-1]. Max employed controlled 2 s concentric\/eccentric actions [~80\u201385% 1RM; 7\u20138 RPE-1]. Results: All training groups improved isokinetic strength (p &lt; 0.01, g = 0.91\u20132.40). HVRT increased brain-derived neurotrophic factor (BDNF) (p = 0.019, g = 0.42) and glutathione peroxidase (GPx) (p &lt; 0.001, g = 0.31). Aecc elicited the strongest osteoanabolic and antioxidant effects (P1NP, p = 0.001, g = 1.21; \u03b2-CTX, p &lt; 0.001, g = 1.82; F2-isoprostanes, p = 0.007, g = 0.94). Max induced moderate bone turnover benefits (P1NP, p = 0.005, g = 1.08; \u03b2-CTX, p &lt; 0.001, g = 1.12), but no GPx or BDNF gains. Controls maintained or declined all variables. Conclusions: EB-RT over 16 weeks improved most outcomes overall, showing modality-specific trends: HVRT favored neuroplasticity, Aecc enhanced redox-inflammatory and bone remodeling responses, and Max improved strength and bone health. These findings support elastic band resistance training as a safe and individualized strategy for healthy aging.<\/jats:p>","DOI":"10.3390\/healthcare13233129","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:31:46Z","timestamp":1764689506000},"page":"3129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-Velocity, Accentuated Eccentric, or Maximal Elastic Band Resistance Training? Effects of Resistance Training Modalities on Bone Health, Isokinetic Strength, and Systemic Biomarkers in Sedentary Older Adults: A Comparative Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-5250","authenticated-orcid":false,"given":"Angel","family":"Saez-Berlanga","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"Research Group in Prevention and Health in Exercise and Sport (PHES), Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5901-5245","authenticated-orcid":false,"given":"Javier","family":"Gene-Morales","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"Research Group in Prevention and Health in Exercise and Sport (PHES), Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1498-949X","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Teixeira","sequence":"additional","affiliation":[{"name":"CIPER -Interdisciplinary Center for the Study of Human Performance, Faculty of Sport Sciences and Physical Education, University of Coimbra, 3040-256 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1377-6495","authenticated-orcid":false,"given":"Ruth","family":"Jim\u00e9nez-Castuera","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences, University of Extremadura, 10003 C\u00e1ceres, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-7805","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Gen\u00e9-Sampedro","sequence":"additional","affiliation":[{"name":"Department of Optics, Optometry and Vision Sciences, University of Valencia, 46100 Valencia, Spain"},{"name":"Research Institute on Traffic and Road Safety, University of Valencia, 46022 Valencia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-4067","authenticated-orcid":false,"given":"Alvaro","family":"Juesas","sequence":"additional","affiliation":[{"name":"Research Group in Prevention and Health in Exercise and Sport (PHES), Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"Department of Education Sciences, CEU Cardenal Herrera University, 46115 Castell\u00f3n, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-5224","authenticated-orcid":false,"given":"Pedro","family":"Gargallo","sequence":"additional","affiliation":[{"name":"Research Group in Prevention and Health in Exercise and Sport (PHES), Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0396-7199","authenticated-orcid":false,"given":"Oscar","family":"Caballero","sequence":"additional","affiliation":[{"name":"Nursing Department, Faculty of Nursing and Podiatry, University of Valencia, 46010 Valencia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-5227","authenticated-orcid":false,"given":"Julio","family":"Fernandez-Garrido","sequence":"additional","affiliation":[{"name":"Nursing Department, Faculty of Nursing and Podiatry, University of Valencia, 46010 Valencia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5135-7913","authenticated-orcid":false,"given":"Carlos","family":"Alix-Fages","sequence":"additional","affiliation":[{"name":"Research Group in Prevention and Health in Exercise and Sport (PHES), Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"Department of Health Research, ICEN Research Center, 38002 Santa Cruz de Tenerife, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2126-2416","authenticated-orcid":false,"given":"Pablo","family":"Jim\u00e9nez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Research Group in Prevention and Health in Exercise and Sport (PHES), Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"Department of Health Research, ICEN Research Center, 38002 Santa Cruz de Tenerife, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-3940","authenticated-orcid":false,"given":"Juan C.","family":"Colado","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"Research Group in Prevention and Health in Exercise and Sport (PHES), Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s40520-021-01968-y","article-title":"Osteosarcopenia, the Co-Existence of Osteoporosis and Sarcopenia, Is Associated with Social Frailty in Older Adults","volume":"34","author":"Inoue","year":"2022","journal-title":"Aging Clin. 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