{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:33:13Z","timestamp":1767699193962,"version":"3.48.0"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Healthcare"],"abstract":"<jats:p>Background: Cancer-directed treatment near the end of life may represent low-value, high-intensity care and potential medical futility, but data from middle-income countries are limited. This study used digitally documented advanced care planning (ACP) in the electronic health record (EHR) and indicators of late oncologic interventions (LOI) within 15 and 30 days before death to examine end-of-life care in Brazil. Objective: To identify factors associated with LOI near death and to explore whether documented ACP is linked to lower treatment intensity. Design: Retrospective cohort study. Setting\/Participants: Adults with metastatic solid tumors who died between January 2022 and December 2023 in two oncology referral hospitals in southern Brazil and had \u22656 months of premortem EHR data. Measurements: LOI were defined as systemic anticancer therapy, radiotherapy, or oncologic surgery within 30 days (LOI-30) or 15 days (LOI-15) before death. Independent predictors were estimated by Poisson regression with robust variance. Results: Among 79 patients, 21.5% received LOI-30 and 8.9% received LOI-15. Breast and lung cancers were the most common primary sites. LOI-30 was independently associated with age &lt; 60 years (relative risk [RR] 3.76; 95% confidence interval [CI] 1.50\u20139.44), higher education (RR 2.07; 95% CI 1.07\u20133.99), and lower platelet count (RR 0.96 per 10,000\/\u00b5L; 95% CI 0.92\u20130.99). ACP was documented for 19% of patients and was associated with absence of LOI-30. Conclusions: Digitally visible ACP in the EHR was associated with reduced aggressive end-of-life care. Using existing EHR infrastructure to prompt and standardize ACP documentation may help align care with patient values in middle-income countries.<\/jats:p>","DOI":"10.3390\/healthcare14020139","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:13:18Z","timestamp":1767697998000},"page":"139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["EHR-Based Advanced Care Planning and Late-Stage Cancer Treatment in a Middle-Income Country: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0135-6530","authenticated-orcid":false,"given":"Matheus Hermes","family":"Leal","sequence":"first","affiliation":[{"name":"Radiotherapy Service, Hospital Ana Nery, Santa Cruz do Sul 96810-002, RS, Brazil"},{"name":"Center for Bioethics, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Rafaella","family":"Funk","sequence":"additional","affiliation":[{"name":"Radiotherapy Service, Hospital Ana Nery, Santa Cruz do Sul 96810-002, RS, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0587-6906","authenticated-orcid":false,"given":"Laura Lima","family":"Camargo","sequence":"additional","affiliation":[{"name":"Radiotherapy Service, Hospital Ana Nery, Santa Cruz do Sul 96810-002, RS, Brazil"},{"name":"Faculty of Medicine, Universidade de Santa Cruz do Sul (UNISC), Santa Cruz do Sul 96815-900, RS, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8083-7895","authenticated-orcid":false,"given":"Francisca","family":"Rego","sequence":"additional","affiliation":[{"name":"Center for Bioethics, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1377-9899","authenticated-orcid":false,"given":"Rui","family":"Nunes","sequence":"additional","affiliation":[{"name":"Center for Bioethics, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1385\/NCC:2:2:198","article-title":"Medical futility: Definition, determination, and disputes in critical care","volume":"2","author":"Bernat","year":"2005","journal-title":"Neurocrit. 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