{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:21:23Z","timestamp":1761110483012,"version":"build-2065373602"},"reference-count":105,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/Multi\/04462\/2013","PD\/BD\/105892\/2014","RNEM-LISBOA-01-0145-FEDER-022125022125","SFRH\/BD\/130911\/2017","Programa Operacional Potencial Humano and the European Social Fund (IF\/01091\/2013)"],"award-info":[{"award-number":["UID\/Multi\/04462\/2013","PD\/BD\/105892\/2014","RNEM-LISBOA-01-0145-FEDER-022125022125","SFRH\/BD\/130911\/2017","Programa Operacional Potencial Humano and the European Social Fund (IF\/01091\/2013)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005856","name":"Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa","doi-asserted-by":"publisher","award":["PD\/BD\/114257\/2016"],"award-info":[{"award-number":["PD\/BD\/114257\/2016"]}],"id":[{"id":"10.13039\/501100005856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["High-Throughput"],"abstract":"<jats:p>The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans\u2014the mercapturomic profile\u2014in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.<\/jats:p>","DOI":"10.3390\/ht8020010","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T03:14:28Z","timestamp":1556075668000},"page":"10","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Mercapturomic Profile of Health and Non-Communicable Diseases"],"prefix":"10.3390","volume":"8","author":[{"given":"Clara","family":"Gon\u00e7alves-Dias","sequence":"first","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-006 Lisboa, Portugal"}]},{"given":"Judit","family":"Morello","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, ULisboa, 1049-001 Lisboa, Portugal"}]},{"given":"Valdir","family":"Semedo","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-006 Lisboa, Portugal"}]},{"given":"M. Jo\u00e3o","family":"Correia","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-006 Lisboa, Portugal"}]},{"given":"Nuno R.","family":"Coelho","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-006 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-0765","authenticated-orcid":false,"given":"Emilia C.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-006 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1827-7369","authenticated-orcid":false,"given":"Alexandra M. M.","family":"Antunes","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, ULisboa, 1049-001 Lisboa, Portugal"}]},{"given":"Sofia A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-006 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ng.566","article-title":"Genetic loci influencing kidney function and chronic kidney disease","volume":"42","author":"Chambers","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S transferases. 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