{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:30:32Z","timestamp":1777645832408,"version":"3.51.4"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT, Portugal)","doi-asserted-by":"publisher","award":["SFRH\/BD\/136767\/2018"],"award-info":[{"award-number":["SFRH\/BD\/136767\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT, Portugal)","doi-asserted-by":"publisher","award":["PTDC\/CVT-WEL\/5207\/2014"],"award-info":[{"award-number":["PTDC\/CVT-WEL\/5207\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT, Portugal)","doi-asserted-by":"publisher","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT, Portugal)","doi-asserted-by":"publisher","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology (FCT, Portugal)","doi-asserted-by":"publisher","award":["UIDB\/00511\/2020"],"award-info":[{"award-number":["UIDB\/00511\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Social Fund and Portuguese funds (MECTES)","award":["SFRH\/BD\/136767\/2018"],"award-info":[{"award-number":["SFRH\/BD\/136767\/2018"]}]},{"name":"European Social Fund and Portuguese funds (MECTES)","award":["PTDC\/CVT-WEL\/5207\/2014"],"award-info":[{"award-number":["PTDC\/CVT-WEL\/5207\/2014"]}]},{"name":"European Social Fund and Portuguese funds (MECTES)","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}]},{"name":"European Social Fund and Portuguese funds (MECTES)","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}]},{"name":"European Social Fund and Portuguese funds (MECTES)","award":["UIDB\/00511\/2020"],"award-info":[{"award-number":["UIDB\/00511\/2020"]}]},{"DOI":"10.13039\/501100001871","name":"national funds through FCT within the scope of ZEBRALGRE","doi-asserted-by":"publisher","award":["SFRH\/BD\/136767\/2018"],"award-info":[{"award-number":["SFRH\/BD\/136767\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"national funds through FCT within the scope of ZEBRALGRE","doi-asserted-by":"publisher","award":["PTDC\/CVT-WEL\/5207\/2014"],"award-info":[{"award-number":["PTDC\/CVT-WEL\/5207\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"national funds through FCT within the scope of ZEBRALGRE","doi-asserted-by":"publisher","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"national funds through FCT within the scope of ZEBRALGRE","doi-asserted-by":"publisher","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"national funds through FCT within the scope of ZEBRALGRE","doi-asserted-by":"publisher","award":["UIDB\/00511\/2020"],"award-info":[{"award-number":["UIDB\/00511\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hydrobiology"],"abstract":"<jats:p>The use of seaweed as a source of bioactive extracts has received increased attention from the market in recent years\u2014particularly for nutraceutical applications. In this context, this study evaluated the nutraceutical application of seaweed biomass and extracts from three seaweeds from Portugal: Ulva sp., Laminaria ochroleuca, and Chondrus crispus. For each of the said seaweeds, four different extracts were obtained using GRAS solvents\u2014acetone (A), ethanol (E), ethanol\u2013water (1:1) (EW), and one polysaccharide-rich extract (P) using water and further precipitation with ethanol. The bioactive potential of the extracts was assessed in terms of antioxidant capacity (ABTS\u2022+, DPPH\u2022, \u2022NO, O2\u2022\u2212 scavenging, and ORAC-FL assay) and anti-inflammatory capacity (COX inhibition and human red blood cell membrane stabilisation). Furthermore, the biochemical profile was determined for the raw biomass and extracts to better comprehend their possible applications as nutraceuticals. The results show that all extracts have antioxidant potential. Five extracts (L. ochroleuca E, EW, and P and Ulva sp. E and P) showed anti-inflammatory capacity. Overall, L. ochroleuca EW extract exhibited the most promising potential as both an antioxidant and anti-inflammatory and is an interesting candidate nutraceutical ingredient.<\/jats:p>","DOI":"10.3390\/hydrobiology1040028","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T03:36:44Z","timestamp":1667360204000},"page":"469-482","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Antioxidant and Anti-Inflammatory Potential of Seaweed Extracts as Functional Ingredients"],"prefix":"10.3390","volume":"1","author":[{"given":"Helena M.","family":"Amaro","sequence":"first","affiliation":[{"name":"CIIMAR\/CIMAR-LA\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edif\u00edcio do Terminal de Cruzeiros de Leix\u00f5es, Avenida General Norton de Matos, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-8896","authenticated-orcid":false,"given":"Fernando","family":"Pagels","sequence":"additional","affiliation":[{"name":"CIIMAR\/CIMAR-LA\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edif\u00edcio do Terminal de Cruzeiros de Leix\u00f5es, Avenida General Norton de Matos, 4450-208 Matosinhos, Portugal"},{"name":"FCUP\u2014Faculty of Science, University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal"}]},{"given":"T\u00e2nia G.","family":"Tavares","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr Roberto Frias, 4200-465 Porto, Portugal"},{"name":"LAQV\/REQUIMTE\u2014Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Isabel","family":"Costa","sequence":"additional","affiliation":[{"name":"CIIMAR\/CIMAR-LA\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edif\u00edcio do Terminal de Cruzeiros de Leix\u00f5es, Avenida General Norton de Matos, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-0553","authenticated-orcid":false,"given":"Isabel","family":"Sousa-Pinto","sequence":"additional","affiliation":[{"name":"CIIMAR\/CIMAR-LA\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edif\u00edcio do Terminal de Cruzeiros de Leix\u00f5es, Avenida General Norton de Matos, 4450-208 Matosinhos, Portugal"},{"name":"FCUP\u2014Faculty of Science, University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9181-512X","authenticated-orcid":false,"given":"A. Catarina","family":"Guedes","sequence":"additional","affiliation":[{"name":"CIIMAR\/CIMAR-LA\u2014Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edif\u00edcio do Terminal de Cruzeiros de Leix\u00f5es, Avenida General Norton de Matos, 4450-208 Matosinhos, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tifs.2011.09.001","article-title":"Seaweeds: A Sustainable Functional Food for Complementary and Alternative Therapy","volume":"23","author":"Mohamed","year":"2012","journal-title":"Trends Food Sci. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10811-010-9632-5","article-title":"Bioactive Compounds in Seaweed: Functional Food Applications and Legislation","volume":"23","author":"Holdt","year":"2011","journal-title":"J. Appl. 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