{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:33:32Z","timestamp":1778567612221,"version":"3.51.4"},"reference-count":222,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.<\/jats:p>","DOI":"10.3390\/ijerph17072326","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T10:29:38Z","timestamp":1585650578000},"page":"2326","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":240,"title":["Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi-Rad","sequence":"first","affiliation":[{"name":"Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8633-2230","authenticated-orcid":false,"given":"C\u00e9lia F.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s\/n, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0378-8887","authenticated-orcid":false,"given":"Farukh","family":"Sharopov","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, 734003 Dushanbe, Tajikistan"}]},{"given":"Anca Oana","family":"Docea","sequence":"additional","affiliation":[{"name":"Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-0644","authenticated-orcid":false,"given":"Asl\u0131","family":"Can Karaca","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey"}]},{"given":"Mehdi","family":"Sharifi-Rad","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran"}]},{"given":"Derya","family":"Kahveci Kar\u0131ncaoglu","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey"}]},{"given":"G\u00f6zde","family":"G\u00fclseren","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Chemical and Metallurgical Faculty, Istanbul Technical University, Maslak Istanbul 34469, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1810-8154","authenticated-orcid":false,"given":"Ezgi","family":"\u015eenol","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Chemical and Metallurgical Faculty, Istanbul Technical University, Maslak Istanbul 34469, Turkey"}]},{"given":"Evren","family":"Demircan","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Chemical and Metallurgical Faculty, Istanbul Technical University, Maslak Istanbul 34469, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0836-236X","authenticated-orcid":false,"given":"Yasaman","family":"Taheri","sequence":"additional","affiliation":[{"name":"Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-0830","authenticated-orcid":false,"given":"Hafiz Ansar Rasul","family":"Suleria","sequence":"additional","affiliation":[{"name":"Department of Agriculture and Food Systems, The University of Melbourne, Melbourne 3010, Australia"}]},{"given":"Beraat","family":"\u00d6z\u00e7elik","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey"},{"name":"Bioactive Research &amp; Innovation Food Manufac. 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Trade Ltd., Katar Street, Teknokent ARI-3, B110, Sar\u0131yer, Istanbul 34467, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-4948","authenticated-orcid":false,"given":"Kadriye","family":"Nur Kasapo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey"}]},{"given":"Mine","family":"G\u00fcltekin-\u00d6zg\u00fcven","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey"}]},{"given":"Ceren","family":"Da\u015fkaya-Dikmen","sequence":"additional","affiliation":[{"name":"Pladis TR R&amp;D Department, K\u0131s\u0131kl\u0131 mah., Ferah cad. \u00dcsk\u00fcdar \u0130stanbul 34692, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-4586","authenticated-orcid":false,"given":"William C.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-5201","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-9116","authenticated-orcid":false,"given":"Daniela","family":"Calina","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pittman, R.N. 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