{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:27:44Z","timestamp":1772252864535,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bonyf AG, Lichtenstein","award":["Article 83. of the Spanish Universities Organic Law; (18\/515-R_P)."],"award-info":[{"award-number":["Article 83. of the Spanish Universities Organic Law; (18\/515-R_P)."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>To assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives (p &gt; 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = 0.001), and the control reported better results in taste (p = 0.03) and in chewing (p = 0.001). The test adhesive showed better (p &lt; 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans. Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.<\/jats:p>","DOI":"10.3390\/ijerph18073398","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T14:51:12Z","timestamp":1616683872000},"page":"3398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9984-653X","authenticated-orcid":false,"given":"Lu\u00eds","family":"Azevedo","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Orofacial Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Cat\u00f3lica Portuguesa, 3504 Viseu, Portugal"}]},{"given":"Andr\u00e9","family":"Correia","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Cat\u00f3lica Portuguesa, 3504 Viseu, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-8282","authenticated-orcid":false,"given":"Carlos F.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Cat\u00f3lica Portuguesa, 3504 Viseu, Portugal"},{"name":"Department of Oral Rehabilitation, Universidade do Porto, 4200 Oporto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-0295","authenticated-orcid":false,"given":"Pedro","family":"Molinero-Mourelle","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Orofacial Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Department of Reconstructive Dentistry and Gerodontology, School of Dental Medicine, University of Bern, 3010 Bern, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-9089","authenticated-orcid":false,"given":"Maria","family":"Correia","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Cat\u00f3lica Portuguesa, 3504 Viseu, Portugal"}]},{"given":"Jaime","family":"Del R\u00edo Highsmith","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Orofacial Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.11607\/jomi.16suppl.g5.1","article-title":"Maxillary Complete Denture Outcomes: A Systematic Review of Patient-Based Outcomes","volume":"31","author":"Thalji","year":"2016","journal-title":"Int. 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