{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:59:40Z","timestamp":1768006780532,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Physical exercise reduces the biochemical markers of obesity, but the effects of multicomponent interventions on these markers should be explored. The present study aimed to elucidate how overweight\/obese adolescents respond to a multicomponent program approach on body composition, physical fitness, and inflammatory markers, using a quasi-experimental study with 33 overweight\/obesity adolescents (control group (CG) = 16; intervention group (IG) = 17). The intervention consisted of 24 weeks with physical exercises and nutritional and psychological guidance. Both groups were evaluated at the pre\/post-intervention moments on body mass index (BMI); body fat (%Fat); waist circumference (WC); waist\/hip ratio (WHR); waist-to-height ratio (WHtR), cardiorespiratory fitness (CRF); abdominal strength, flexibility; leptin; interleukin 6; interleukin 10; and tumor necrosis factor-alpha. Mixed-analysis of variance and generalized estimation equations were used for statistical analysis. There was an interaction effect between groups and time on %Fat (p = 0.002), WC (p = 0.023), WHR (p &lt; 0.001), WHtR (p = 0.035), CRF (p = 0.050), and leptin (p = 0.026). Adolescents were classified as 82.4% responders for %Fat, 70.6% for WC, 88.2% for WHR, and 70.6% for CRF. Further, there was an association between changes in %Fat (p = 0.033), WC (p = 0.032), and WHR (p = 0.033) between responders and non-responders with CRF in the IG. There was a positive effect on body composition, physical fitness, and leptin. In addition, reductions in body composition parameters were explained by CRF improvements.<\/jats:p>","DOI":"10.3390\/ijerph18147267","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T12:31:25Z","timestamp":1625661085000},"page":"7267","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects and Responsiveness of a Multicomponent Intervention on Body Composition, Physical Fitness, and Leptin in Overweight\/Obese Adolescents"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2340-2443","authenticated-orcid":false,"given":"Leticia","family":"Borfe","sequence":"first","affiliation":[{"name":"Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90690-200, Brazil"}]},{"given":"Caroline","family":"Brand","sequence":"additional","affiliation":[{"name":"Graduate Program on Health Promotion, University of Santa Cruz do Sul, Santa Cruz do Sul 96816-501, Brazil"}]},{"given":"Let\u00edcia de Borba","family":"Schneiders","sequence":"additional","affiliation":[{"name":"Graduate Program on Health Promotion, University of Santa Cruz do Sul, Santa Cruz do Sul 96816-501, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-9181","authenticated-orcid":false,"given":"Jorge","family":"Mota","sequence":"additional","affiliation":[{"name":"Research Center in Physical Activity, Health and Leisure, Faculty of Sports, University of Porto, 4200-450 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7795-6575","authenticated-orcid":false,"given":"Claudia Regina","family":"Cavaglieri","sequence":"additional","affiliation":[{"name":"Department of Adapted Physical Activity Studies, University State Campinas, Campinas 13083-851, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-6697","authenticated-orcid":false,"given":"Neiva","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Physical Education, University of Paran\u00e1, Curitiba 81690-100, Brazil"}]},{"given":"Jane Dagmar Pollo","family":"Renner","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Graduate Program on Health Promotion, University of Santa Cruz do Sul, Santa Cruz do Sul 96816-501, Brazil"}]},{"given":"C\u00e9zane Priscila","family":"Reuter","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Graduate Program on Health Promotion, University of Santa Cruz do Sul, Santa Cruz do Sul 96816-501, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-6947","authenticated-orcid":false,"given":"Anelise Reis","family":"Gaya","sequence":"additional","affiliation":[{"name":"Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90690-200, Brazil"},{"name":"Graduate Program in Human Movement Sciences, School of Physical Education, Federal University of Rio Grande do Sul, Porto Alegre 90690-200, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021, June 03). 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