{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T19:52:25Z","timestamp":1778269945044,"version":"3.51.4"},"reference-count":128,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Aging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes in order to maintain homeostasis; they also influence the function of endothelial cells, smooth muscle cells, and immune cells in the vessel wall. A clock misalignment could favor vascular damage and indirectly also affect skeletal muscle function. In this review, we focus on the dysregulation of circadian rhythm due to aging and its relationship with skeletal muscle changes and vascular health as possible risk factors for the development of sarcopenia, as well as the role of physical exercise as a potential modulator of these processes.<\/jats:p>","DOI":"10.3390\/ijerph182412949","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T02:07:18Z","timestamp":1639102038000},"page":"12949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging"],"prefix":"10.3390","volume":"18","author":[{"given":"Bruna Spolador de Alencar","family":"Silva","sequence":"first","affiliation":[{"name":"Exercise and Immunometabolism Research Group, Universidade Estadual Paulista (UNESP), Presidente Prudente, S\u00e3o Paulo 19060-560, Brazil"}]},{"given":"Juliana Souza","family":"Uzeloto","sequence":"additional","affiliation":[{"name":"Exercise and Immunometabolism Research Group, Universidade Estadual Paulista (UNESP), Presidente Prudente, S\u00e3o Paulo 19060-560, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-1003","authenticated-orcid":false,"given":"F\u00e1bio Santos","family":"Lira","sequence":"additional","affiliation":[{"name":"Exercise and Immunometabolism Research Group, Universidade Estadual Paulista (UNESP), Presidente Prudente, S\u00e3o Paulo 19060-560, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-7774","authenticated-orcid":false,"given":"Telmo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Clinical Physiology, Coimbra Health School, Polytechnic Institute of Coimbra, Rua 5 de Outubro\u2014SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal"},{"name":"Laboratory for Applied Health Research (LabinSa\u00fade), Rua 5 de Outubro\u2014SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4512-7331","authenticated-orcid":false,"given":"Manuel J.","family":"Coelho-E-Silva","sequence":"additional","affiliation":[{"name":"Faculty of Sport Science and Physical Education, University of Coimbra, 3004-531 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7844-0506","authenticated-orcid":false,"given":"Armando","family":"Caseiro","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Health Research (LabinSa\u00fade), Rua 5 de Outubro\u2014SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal"},{"name":"Unidade I&D Qu\u00edmica-F\u00edsica Molecular, Faculdade de Ci\u00eancias e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal"},{"name":"Biomedical Laboratory Sciences, Coimbra Health School, Polytechnic Institute of Coimbra, Rua 5 de Outubro\u2014SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1172\/JCI90328","article-title":"The aging clock: Circadian rhythms and later life","volume":"127","author":"Hood","year":"2017","journal-title":"J. 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