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Workers\u2019 Functional Work Ability (FWA) status is used to create Occupational Health Protection Profiles (OHPP). This is a novel longitudinal study in comparison with previous research that has predominantly relied on the causality and explainability of human-understandable models for industrial technical teams like ergonomists. The application of artificial intelligence can support the decision-making to go from a worker\u2019s Functional Work Ability to explanations by integrating explainability into medical (restriction) and support in contexts of individual, work-related, and organizational risk conditions. A sample of 7857 for the prognosis part of OHPP based on Functional Work Ability in the Portuguese language in the automotive industry was taken from 2019 to 2021. The most suitable regression models to predict the next medical appointment for the workers\u2019 body parts protection were the models based on CatBoost regression, with an RMSLE of 0.84 and 1.23 weeks (mean error), respectively. CatBoost algorithm is also used to predict the next body part severity of OHPP. This information can help our understanding of potential risk factors for OHPP and identify warning signs of the early stages of musculoskeletal symptoms and work-related absenteeism.<\/jats:p>","DOI":"10.3390\/ijerph19159552","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T20:52:01Z","timestamp":1659559921000},"page":"9552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human-Centered Explainable Artificial Intelligence: Automotive Occupational Health Protection Profiles in Prevention Musculoskeletal Symptoms"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-489X","authenticated-orcid":false,"given":"Nafiseh","family":"Mollaei","sequence":"first","affiliation":[{"name":"LIBPhys, Physics Department, Faculty of Sciences and Technology, Nova University of Lisbon, 2825-149 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1433-5712","authenticated-orcid":false,"given":"Carlos","family":"Fujao","sequence":"additional","affiliation":[{"name":"Volkswagen Autoeuropa, Industrial Engineering and Lean Management, Quinta da Marquesa, 2954-024 Quinta do Anjo, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-0571","authenticated-orcid":false,"given":"Luis","family":"Silva","sequence":"additional","affiliation":[{"name":"LIBPhys, Physics Department, Faculty of Sciences and Technology, Nova University of Lisbon, 2825-149 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7320-511X","authenticated-orcid":false,"given":"Joao","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"LIBPhys, Physics Department, Faculty of Sciences and Technology, Nova University of Lisbon, 2825-149 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-976X","authenticated-orcid":false,"given":"Catia","family":"Cepeda","sequence":"additional","affiliation":[{"name":"LIBPhys, Physics Department, Faculty of Sciences and Technology, Nova University of Lisbon, 2825-149 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-7424","authenticated-orcid":false,"given":"Hugo","family":"Gamboa","sequence":"additional","affiliation":[{"name":"LIBPhys, Physics Department, Faculty of Sciences and Technology, Nova University of Lisbon, 2825-149 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1177\/105960118901400403","article-title":"The relationship between job security and employee health","volume":"14","author":"Kuhnert","year":"1989","journal-title":"Group Organ. 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