{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:07:32Z","timestamp":1762070852504,"version":"build-2065373602"},"reference-count":80,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss National Science Foundation","award":["51NF40-185901","10001C_189407","UIDB\/50009\/2020"],"award-info":[{"award-number":["51NF40-185901","10001C_189407","UIDB\/50009\/2020"]}]},{"name":"LARSyS\u2014Portuguese national funding agency for science, research and technology (FCT) pluriannual funding 2020\u20132023","award":["51NF40-185901","10001C_189407","UIDB\/50009\/2020"],"award-info":[{"award-number":["51NF40-185901","10001C_189407","UIDB\/50009\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This study aimed (1) to investigate the association between body mass index (BMI), physical activity (PA), and physical function (PF) with health-related quality of life (HRQoL), and (2) to examine in-depth whether PA and PF mediate the relationship between BMI and HRQoL in older adults. We investigated 802 individuals (mean age 69.8 \u00b1 5.6 years), residents of the Autonomous Region of Madeira, Portugal. Harmol and PA were assessed using the SF-36 and Baecke questionnaires, respectively, and PF by the Senior Fitness Test. The prevalence of overweight was 71.3%, 26.5% for normal weight, and 2.1% for underweight. We verified a small correlation between age and sex with BMI, PA, PF, and medium borderline with HRQoL. After adjusting for covariates (i.e., sex, age, comorbidities), the multivariate regression analysis indicated a 93.1% chance of improvement in HRQoL for low BMI, while PA and PF revealed a chance of increasing HRQoL by 91.8% and 60.0%, respectively. According to the serial mediation pathway, PA and PF partially mediated the association between BMI and HRQoL by 32.3% and 81.5%, respectively. The total variance of the model was 90%. It was concluded that BMI can negatively affect HRQoL. On the other hand, PA and PF are able to increase HRQoL levels during the aging process.<\/jats:p>","DOI":"10.3390\/ijerph192113718","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T02:31:03Z","timestamp":1666578663000},"page":"13718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Mediating Role of Physical Activity and Physical Function in the Association between Body Mass Index and Health-Related Quality of Life: A Population-Based Study with Older Adults"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3577-3439","authenticated-orcid":false,"given":"Marcelo de Maio","family":"Nascimento","sequence":"first","affiliation":[{"name":"Department of Physical Education, Federal University of Vale do S\u00e3o Francisco, Petrolina 56304-917, PE, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-692X","authenticated-orcid":false,"given":"\u00c9lvio R\u00fabio","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, University of Madeira, 9020-105 Funchal, Portugal"},{"name":"LARSYS\u2014Laboratory for Robotics and Engineering System, Interactive Technologies Institute, 9020-105 Funchal, Portugal"},{"name":"Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, 1205 Geneva, Switzerland"}]},{"given":"Bruna R.","family":"Gouveia","sequence":"additional","affiliation":[{"name":"LARSYS\u2014Laboratory for Robotics and Engineering System, Interactive Technologies Institute, 9020-105 Funchal, Portugal"},{"name":"Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Regional Directorate of Health, Secretary of Health of the Autonomous Region of Madeira, 9004-515 Funchal, Portugal"},{"name":"Saint Joseph of Cluny Higher School of Nursing, 9050-535 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-7771","authenticated-orcid":false,"given":"Adilson","family":"Marques","sequence":"additional","affiliation":[{"name":"CIPER, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, University of Lisbon, 1499-002 Cruz Quebrada, Portugal"},{"name":"Environmental Health Institute (ISAMB), University of Lisbon, 1649-020 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7706-5038","authenticated-orcid":false,"given":"Pedro","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Informatics Engineering and Interactive Media Design, University of Madeira, 9000-072 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7212-1974","authenticated-orcid":false,"given":"Jes\u00fas","family":"Garc\u00eda-Mayor","sequence":"additional","affiliation":[{"name":"Public Health and Epidemiology Research Group, San Javier Campus, University of Murcia, 30720 San Javier, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2128-4116","authenticated-orcid":false,"given":"Krzysztof","family":"Przednowek","sequence":"additional","affiliation":[{"name":"Institute of Physical Culture Sciences, Medical College, University of Rzesz\u00f3w, 35-959 Rzesz\u00f3w, Poland"}]},{"given":"Andreas","family":"Ihle","sequence":"additional","affiliation":[{"name":"Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Department of Psychology, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Swiss National Centre of Competence in Research LIVES\u2014Overcoming Vulnerability: Life Course Perspectives, 1015 Lausanne, Switzerland"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1001\/jama.2016.6458","article-title":"Trends in Obesity among Adults in the United States, 2005 to 2014","volume":"315","author":"Flegal","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.mehy.2010.02.033","article-title":"Is thermogenesis a significant causal factor in preventing the \u201cglobesity\u201d epidemic?","volume":"75","author":"Hansen","year":"2010","journal-title":"Med. 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