{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:25:27Z","timestamp":1774992327618,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Inflammation is considered to be a vital defense mechanism for health, acting as a protective response of the immune system through a satisfactory inflammatory biomarker response (IBR). IBR, as well as being beneficial to the organism, can be also responsible for a variety of chronic inflammatory diseases. Whole-body vibration (WBV) exercise is a type of physical exercise that can act on inflammation responses due its capacity for stimulating the sensory components that promote systemic responses. The objective of this study was to investigate the effects of WBV on IBR in different clinical status. Methods: This is a systematic review that includes randomized controlled trials (RCTs) on the effects of WBV exercise on IBR. The methodological quality, risk of bias, and level of evidence were rated. Results: Four RCTs met the selection criteria. The studies showed benefits associated with IBR (e.g., cytokines, adipokines, and C-reactive protein) in various clinical conditions, including healthy populations and some chronic diseases (such as obesity, aging disorders, and knee osteoarthritis), using several WBV protocols. Conclusions: WBV might be useful in the management of inflammatory conditions.<\/jats:p>","DOI":"10.3390\/ijerph192214853","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T02:29:32Z","timestamp":1668392972000},"page":"14853","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inflammatory Biomarker Responses to Whole-Body Vibration in Subjects with Different Clinical Status: A Systematic Review"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-1328","authenticated-orcid":false,"given":"Elo\u00e1","family":"Moreira-Marconi","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Vibra\u00e7\u00f5es Mec\u00e2nicas e Pr\u00e1ticas Integrativas-LAVIMPI, Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alc\u00e2ntara Gomes and Policl\u00ednica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Fisiopatologia Cl\u00ednica e Experimental, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"},{"name":"Departamento de Fisioterapia, Universidade Estacio de S\u00e1, Rio de Janeiro 20771-900, Brazil"}]},{"given":"Ygor","family":"Teixeira-Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vibra\u00e7\u00f5es Mec\u00e2nicas e Pr\u00e1ticas Integrativas-LAVIMPI, Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alc\u00e2ntara Gomes and Policl\u00ednica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Departamento de Fisioterapia, Universidade Estacio de S\u00e1, Rio de Janeiro 20771-900, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"}]},{"given":"Alexandre Gon\u00e7alves de","family":"Meirelles","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vibra\u00e7\u00f5es Mec\u00e2nicas e Pr\u00e1ticas Integrativas-LAVIMPI, Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alc\u00e2ntara Gomes and Policl\u00ednica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Departamento de Fisioterapia, Universidade Estacio de S\u00e1, Rio de Janeiro 20771-900, Brazil"},{"name":"Mestrado Profissional em Sa\u00fade, Medicina Laboratorial e Tecnologia Forense, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"}]},{"given":"Maria Eduarda de Souza","family":"Melo-Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vibra\u00e7\u00f5es Mec\u00e2nicas e Pr\u00e1ticas Integrativas-LAVIMPI, Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alc\u00e2ntara Gomes and Policl\u00ednica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Mestrado Profissional em Sa\u00fade, Medicina Laboratorial e Tecnologia Forense, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-3692","authenticated-orcid":false,"given":"Aline Cristina Gomes","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vibra\u00e7\u00f5es Mec\u00e2nicas e Pr\u00e1ticas Integrativas-LAVIMPI, Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alc\u00e2ntara Gomes and Policl\u00ednica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Fisiopatologia Cl\u00ednica e Experimental, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"}]},{"given":"Aline","family":"Reis-Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vibra\u00e7\u00f5es Mec\u00e2nicas e Pr\u00e1ticas Integrativas-LAVIMPI, Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alc\u00e2ntara Gomes and Policl\u00ednica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-5056","authenticated-orcid":false,"given":"Laisa Liane","family":"Paineiras-Domingos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vibra\u00e7\u00f5es Mec\u00e2nicas e Pr\u00e1ticas Integrativas-LAVIMPI, Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alc\u00e2ntara Gomes and Policl\u00ednica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"},{"name":"Departamento de Fisioterapia, Instituto Multidisciplinar de Reabilita\u00e7\u00e3o e Sa\u00fade, Universidade Federal da Bahia, Salvador 40110-060, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6563-8246","authenticated-orcid":false,"given":"Aderito","family":"Seixas","sequence":"additional","affiliation":[{"name":"Escola Superior de Sa\u00fade Fernando Pessoa, 4249-004 Porto, Portugal"}]},{"given":"Carla da Fontoura","family":"Dionello","sequence":"additional","affiliation":[{"name":"Departamento de Reumatologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-1576","authenticated-orcid":false,"given":"Dan\u00fabia da Cunha de","family":"S\u00e1-Caputo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vibra\u00e7\u00f5es Mec\u00e2nicas e Pr\u00e1ticas Integrativas-LAVIMPI, Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alc\u00e2ntara Gomes and Policl\u00ednica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Fisiopatologia Cl\u00ednica e Experimental, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4718-448X","authenticated-orcid":false,"given":"Mario","family":"Bernardo-Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vibra\u00e7\u00f5es Mec\u00e2nicas e Pr\u00e1ticas Integrativas-LAVIMPI, Departamento de Biof\u00edsica e Biometria, Instituto de Biologia Roberto Alc\u00e2ntara Gomes and Policl\u00ednica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cell.2015.02.010","article-title":"Homeostasis, Inflammation, and Disease Susceptibility","volume":"160","author":"Kotas","year":"2015","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: New Adventures of an Old Flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in 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