{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T22:06:20Z","timestamp":1764194780678,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: With the aging population comes greater risks associated with polypharmacy, a significant public health problem. Objective: This study aimed to identify the prevalence of polypharmacy and its associated factors through Comprehensive Geriatric Assessment (CGA) among older adults treated in primary health care (PHC) in a large Brazilian urban center. Methods: We conducted a cross-sectional study with a random sampling of 400 older adults using primary health care. Polypharmacy was defined as the cumulative use of five or more daily medications. An assessment of a sociodemographic and health survey, fear of falling, and physical disabilities affecting activities of daily living and instrumental activities of daily living was conducted. Results: The mean age was 75.23 (SD: 8.53) years. The prevalence of polypharmacy and hyperpolypharmacy was 37% (n = 148) and 1% (n = 4), respectively. The adjusted logistic regression showed that participants with chronic non-communicable diseases (CNCDs) (OR = 9.24; p = 0.003), diabetes (OR = 1.93; p = 0.003), and obesity (OR = 2.15; p = 0.005) were associated with a greater propensity to use polypharmacy. Conclusion: Our results show that older adults with CNCDs, diabetes, and obesity were more likely to use polypharmacy. The results reinforce the importance of using CGA in clinical practice in PHC.<\/jats:p>","DOI":"10.3390\/ijerph20095730","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T08:12:11Z","timestamp":1683274331000},"page":"5730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of Polypharmacy of Older People in a Large Brazilian Urban Center and its Associated Factors"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1023-8488","authenticated-orcid":false,"given":"Luciano Magalh\u00e3es","family":"Vitorino","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine of Itajub\u00e1, Itajub\u00e1 37502-138, MG, Brazil"}]},{"given":"Jorge Henrique","family":"Lopes Mendes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine of Itajub\u00e1, Itajub\u00e1 37502-138, MG, Brazil"}]},{"given":"Gerson","family":"de Souza Santos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centro Universit\u00e1rio Ages, Paripiranga 37550-030, BA, Brazil"}]},{"given":"Cl\u00e1udia","family":"Oliveira","sequence":"additional","affiliation":[{"name":"School of Health Atl\u00e2ntica (ESSATLA), 2730-036 Oeiras, Portugal"},{"name":"Health Sciences Research Unit: Nursing (UICISA: E), Coimbra Nursing School, 3045-043 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2626-8561","authenticated-orcid":false,"given":"Helena","family":"Jos\u00e9","sequence":"additional","affiliation":[{"name":"School of Health Atl\u00e2ntica (ESSATLA), 2730-036 Oeiras, Portugal"},{"name":"Health Sciences Research Unit: Nursing (UICISA: E), Coimbra Nursing School, 3045-043 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-5690","authenticated-orcid":false,"given":"Lu\u00eds","family":"Sousa","sequence":"additional","affiliation":[{"name":"School of Health Atl\u00e2ntica (ESSATLA), 2730-036 Oeiras, Portugal"},{"name":"Comprehensive Health Research Centre (CHRC), 7000-811 Evora, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/aje\/kwx387","article-title":"The Brazilian Longitudinal Study of Aging (ELSI-Brazil): Objectives and Design","volume":"187","author":"Neri","year":"2018","journal-title":"Am. 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