{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:10:02Z","timestamp":1760134202352,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pfizer (Italy)","award":["12798939"],"award-info":[{"award-number":["12798939"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Considering the multidimensionality of chronic pain, it is crucial to develop comprehensive strategies for its effective management. However, establishing well-defined, evidence-based guidelines for such approaches remains challenging. To overcome this, we present the finding from a 4-month intervention to enhance the management of non-cancer chronic pain in older adults with pre-frailty and frailty. The intervention\u2019s core elements comprised a multidisciplinary individualized plan, a case manager, and patient education. This pilot study involved 22 participants (\u226565 years). It assessed changes in pain frequency and intensity (pain scale), frailty (Fried frailty phenotype criteria), and medication adherence (Brief Adherence Rating Scale) before and after the 4-month intervention. The results were encouraging: pain frequency and intensity and frailty score tended to decrease, and medication adherence showed significant improvement. This preliminary small-scale pilot study provides a foundation for further research and for exploring the potential scalability of this multidisciplinary patient-centred intervention.<\/jats:p>","DOI":"10.3390\/ijerph20247150","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T11:32:29Z","timestamp":1701862349000},"page":"7150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Managing Non-Cancer Chronic Pain in Frail Older Adults: A Pilot Study Based on a Multidisciplinary Approach"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0183-000X","authenticated-orcid":false,"given":"Teodora","family":"Figueiredo","sequence":"first","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Porto4Ageing\u2014Competences Centre on Active and Healthy Ageing, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-2554","authenticated-orcid":false,"given":"Lu\u00eds","family":"Mid\u00e3o","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Porto4Ageing\u2014Competences Centre on Active and Healthy Ageing, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-6653","authenticated-orcid":false,"given":"Rute","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"CINTESIS@RISE, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Joana","family":"Carrilho","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Porto4Ageing\u2014Competences Centre on Active and Healthy Ageing, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-3536","authenticated-orcid":false,"given":"Constantino","family":"Coelho","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Porto4Ageing\u2014Competences Centre on Active and Healthy Ageing, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Giovanni","family":"Cerullo","sequence":"additional","affiliation":[{"name":"Palliative Care, Centro Hospitalar Universit\u00e1rio do Algarve, 8000-386 Algarve, Portugal"}]},{"given":"Antonella","family":"Di Paola","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Gemelli IRCCS, 00168 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-7003","authenticated-orcid":false,"given":"Angelo","family":"Carf\u00ec","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Gemelli IRCCS, 00168 Rome, Italy"}]},{"given":"Graziano","family":"Onder","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Department of Geriatric and Orthopedic Sciences, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-1480","authenticated-orcid":false,"given":"El\u00edsio","family":"Costa","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Porto4Ageing\u2014Competences Centre on Active and Healthy Ageing, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/j.pain.0000000000001390","article-title":"The IASP classification of chronic pain for ICD-11: Chronic primary pain","volume":"160","author":"Nicholas","year":"2019","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.12659\/MSM.911260","article-title":"Prevalence of Chronic Pain, Particularly with Neuropathic Component, and Its Effect on Overall Functioning of Elderly Patients","volume":"25","author":"Grodzicki","year":"2019","journal-title":"Med. 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