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Applications in epidemiology have linked variations in time allocation between behaviors to key health outcomes, including adiposity, cardiometabolic health, cognitive function, fitness, quality of life, glycomics, clinical psychometrics, and mental well-being. Research consistently shows that reallocating time from sedentary behavior to sleep or moderate-to-vigorous physical activity (MVPA) improves health outcomes. Importantly, CoDA reveals that optimal activity patterns vary across populations, supporting the need for personalized, context-specific recommendations rather than one-size-fits-all guidelines. 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