{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T19:03:56Z","timestamp":1774292636876,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T00:00:00Z","timestamp":1252454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Salvia officinalis (common sage) is a plant with antidiabetic properties. A pilot trial (non-randomized crossover trial) with six healthy female volunteers (aged 40-50) was designed to evaluate the beneficial properties of sage tea consumption on blood glucose regulation, lipid profile and transaminase activity in humans. Effects of sage consumption on erythrocytes\u2019 SOD and CAT activities and on Hsp70 expression in lymphocytes were also evaluated. Four weeks sage tea treatment had no effects on plasma glucose. An improvement in lipid profile was observed with lower plasma LDL cholesterol and total cholesterol levels as well as higher plasma HDL cholesterol levels during and two weeks after treatment. Sage tea also increased lymphocyte Hsp70 expression and erythrocyte SOD and CAT activities. No hepatotoxic effects or other adverse effects were observed.<\/jats:p>","DOI":"10.3390\/ijms10093937","type":"journal-article","created":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T02:40:52Z","timestamp":1252550452000},"page":"3937-3950","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Sage Tea Drinking Improves Lipid Profile and Antioxidant Defences in Humans"],"prefix":"10.3390","volume":"10","author":[{"given":"Carla  M.","family":"S\u00e1","sequence":"first","affiliation":[{"name":"CBMA\u2013Centre of Molecular and Environmental Biology\/Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Alice  A.","family":"Ramos","sequence":"additional","affiliation":[{"name":"CBMA\u2013Centre of Molecular and Environmental Biology\/Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Marisa  F.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"CBMA\u2013Centre of Molecular and Environmental Biology\/Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Cristovao  F.","family":"Lima","sequence":"additional","affiliation":[{"name":"CITAB\u2013Centre for the Research and Technology of Agro-Environment and Biological Sciences\/Department of Biology, School of Sciences, University of Minho, 4710-057 Braga, Portugal"}]},{"given":"Manuel","family":"Fernandes-Ferreira","sequence":"additional","affiliation":[{"name":"CITAB\u2013Centre for the Research and Technology of Agro-Environment and Biological Sciences\/Department of Biology, School of Sciences, University of Minho, 4710-057 Braga, Portugal"}]},{"given":"Cristina","family":"Pereira-Wilson","sequence":"additional","affiliation":[{"name":"CBMA\u2013Centre of Molecular and Environmental Biology\/Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2009,9,9]]},"reference":[{"key":"ref_1","unstructured":"Williams, G, and Pickup, JC (2004). Handbook of Diabetes, Blackwell Publishing Ltd. [3rd ed]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/414821a","article-title":"New drug targets for type 2 diabetes and the metabolic syndrome","volume":"414","author":"Moller","year":"2001","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cccn.2005.03.036","article-title":"Postprandial hypertriglyceridemia and oxidative stress in patients of type 2 diabetes mellitus with macrovascular complications","volume":"359","author":"Saxena","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"50K","DOI":"10.1016\/j.amjcard.2005.08.008","article-title":"High-density lipoprotein as a therapeutic target: Clinical evidence and treatment strategies","volume":"96","author":"Toth","year":"2005","journal-title":"Am. J. Cardiol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1177\/000331970505600411","article-title":"Hyperglycemia, lipoprotein glycation, and vascular disease","volume":"56","author":"Veiraiah","year":"2005","journal-title":"Angiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1080\/14786410701590426","article-title":"Determination of chemopreventive role of Foeniculum vulgare and Salvia officinalis infusion on trichloroacetic acid-induced increased serum marker enzymes lipid peroxidation and antioxidative defense systems in rats","volume":"22","author":"Celik","year":"2008","journal-title":"Nat. Prod. Res"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0009-9120(99)00075-2","article-title":"Antioxidant enzymes and human diseases","volume":"32","author":"Castro","year":"1999","journal-title":"Clin. Biochem"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.physiol.61.1.243","article-title":"Heat-shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology","volume":"61","author":"Feder","year":"1999","journal-title":"Annu. Rev. Physiol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1383-5742(02)00003-0","article-title":"Biomarkers in molecular epidemiology studies for health risk prediction","volume":"511","author":"Bonassi","year":"2002","journal-title":"Mutat. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1379\/1466-1268(2004)009<0069:SALLOH>2.0.CO;2","article-title":"Serum and lymphocyte levels of heat shock protein 70 in aging: A study in the normal Chinese population","volume":"9","author":"Jin","year":"2004","journal-title":"Cell Stress Chaperon"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.nutr.23.011702.073027","article-title":"Nutrition and prevention of type 2 diabetes","volume":"23","author":"Costacou","year":"2003","journal-title":"Annu. Rev. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1368-5031.2006.00929.x","article-title":"Diabetes prevention: Is there more to it than lifestyle changes?","volume":"60","author":"Gruber","year":"2006","journal-title":"Int. J. Clin. Pract"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.diabres.2005.03.010","article-title":"Can type 2 diabetes mellitus be considered preventable?","volume":"68","author":"Jermendy","year":"2005","journal-title":"Diabetes Res. Clin. Pract"},{"key":"ref_14","first-page":"7","article-title":"An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract","volume":"24","author":"Fernandes","year":"2007","journal-title":"BMC Complement Altern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1055\/s-2006-959693","article-title":"Hypoglycaemic effect of Coccinia indica: Mechanism of action","volume":"59","author":"Kumar","year":"1993","journal-title":"Planta Med"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0378-8741(02)00294-5","article-title":"Effect of Coccinia indica leaves on antioxidant status in streptozotocin-induced diabetic rats","volume":"84","author":"Venkateswaran","year":"2003","journal-title":"J. Ethnopharmacol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.nutres.2006.09.014","article-title":"Green tea consumption improves plasma lipid profile in adults","volume":"26","author":"Coimbra","year":"2006","journal-title":"Nutr. Res"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.clnu.2006.01.022","article-title":"The effect of green tea in oxidative stress","volume":"25","author":"Coimbra","year":"2006","journal-title":"Clin. Nutr"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00394-007-0690-7","article-title":"Effects of black and green tea consumption on blood glucose levels in non-obese elderly men and women from Mediterranean Islands (MEDIS epidemiological study)","volume":"47","author":"Polychronopoulos","year":"2008","journal-title":"Eur. J. Nutr"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ptr.914","article-title":"Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice","volume":"16","year":"2002","journal-title":"Phytother. Res"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jep.2005.03.008","article-title":"Effect of Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats","volume":"100","author":"Eidi","year":"2005","journal-title":"J. Ethnopharmacol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1079\/BJN20061832","article-title":"Metformin-like effects of Salvia officinalis (common sage): Is it useful in diabetes prevention?","volume":"96","author":"Lima","year":"2006","journal-title":"Br. J. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/hep.510300526","article-title":"Clinical features of hepatitis C-infected patients with persistently normal alanine transaminase levels in the Southwestern United States","volume":"30","author":"Jamal","year":"1999","journal-title":"Hepatology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/bmj.38050.593634.63","article-title":"Normal serum aminotransferase concentration and risk of mortality from liver diseases: Prospective cohort study","volume":"328","author":"Kim","year":"2004","journal-title":"BMJ"},{"key":"ref_25","unstructured":"Ravel, R (1989). Clinical Laboratory Medicine: Clinical Application of Laboratory Data, Mosby-Year Book Inc. [5th ed]."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0009-8981(01)00720-3","article-title":"Screening for cardiovascular disease with cholesterol","volume":"315","author":"Sullivan","year":"2002","journal-title":"Clin. Chim. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2165\/00129784-200505060-00005","article-title":"Beyond low-density lipoprotein: Addressing the atherogenic lipid triad in type 2 diabetes mellitus and the metabolic syndrome","volume":"5","author":"Nesto","year":"2005","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00394-007-0693-4","article-title":"Plant sterol-enriched fermented milk enhances the attainment of LDL-cholesterol goal in hypercholesterolemic subjects","volume":"47","author":"Plana","year":"2008","journal-title":"Eur. J. Nutr"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0955-2863(03)00054-8","article-title":"Effect of EGCG on lipid absorption and plasma lipid levels in rats","volume":"14","author":"Raederstorff","year":"2003","journal-title":"J. Nutr. Biochem"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/jcb.1233","article-title":"Salvia miltiorrhiza inhibits intimal hyperplasia and monocyte chemotactic protein-1 expression after balloon injury in cholesterol-fed rabbits","volume":"83","author":"Chen","year":"2001","journal-title":"J. Cell Biochem"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/1040869059096","article-title":"Dietary polyphenols and the prevention of diseases","volume":"45","author":"Scalbert","year":"2005","journal-title":"Crit. Rev. Food Sci. Nutr"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jep.2004.11.029","article-title":"The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats","volume":"97","author":"Lima","year":"2005","journal-title":"J. Ethnopharmacol"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.lfs.2006.06.042","article-title":"Phenolic compounds protect HepG2 cells from oxidative damage: Relevance of glutathione levels","volume":"79","author":"Lima","year":"2006","journal-title":"Life Sci"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cbi.2007.01.020","article-title":"Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage","volume":"167","author":"Lima","year":"2007","journal-title":"Chem. Biol. Interact"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fct.2006.09.009","article-title":"Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice","volume":"45","author":"Lima","year":"2007","journal-title":"Food Chem. Toxicol"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"18033","DOI":"10.1074\/jbc.272.29.18033","article-title":"Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance","volume":"272","author":"Gabai","year":"1997","journal-title":"J. Biol. Chem"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.mehy.2004.08.033","article-title":"Induction of heat shock proteins may combat insulin resistance","volume":"66","author":"McCarty","year":"2006","journal-title":"Med. Hypotheses"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/01.RES.0000057754.35180.99","article-title":"Liposomal delivery of heat shock protein 72 into renal tubular cells blocks nuclear factor-kappaB activation, tumor necrosis factor-alpha production, and subsequent ischemia-induced apoptosis","volume":"92","author":"Meldrum","year":"2003","journal-title":"Circ. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/emboj\/20.3.446","article-title":"Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase","volume":"20","author":"Park","year":"2001","journal-title":"EMBO J"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.2337\/diabetes.52.9.2338","article-title":"Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism","volume":"52","author":"Bruce","year":"2003","journal-title":"Diabetes"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2337\/diabetes.51.4.1102","article-title":"Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance","volume":"51","author":"Kurucz","year":"2002","journal-title":"Diabetes"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1073\/pnas.0705799105","article-title":"HSP72 protects against obesity-induced insulin resistance","volume":"105","author":"Chung","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1152\/japplphysiol.91210.2008","article-title":"Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats","volume":"106","author":"Gupte","year":"2009","journal-title":"J. Appl. Physiol"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/ars.2007.1866","article-title":"Resveratrol induces the heat-shock response and protects human cells from severe heat stress","volume":"10","author":"Putics","year":"2008","journal-title":"Antioxid. Redox. Signal"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1379\/CSC-51R.1","article-title":"Paeoniflorin, a novel heat shock protein-inducing compound","volume":"9","author":"Yan","year":"2004","journal-title":"Cell Stress Chaperones"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/10\/9\/3937\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:11:08Z","timestamp":1760220668000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/10\/9\/3937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,9]]},"references-count":46,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,9]]}},"alternative-id":["i10093937"],"URL":"https:\/\/doi.org\/10.3390\/ijms10093937","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,9]]}}}