{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:52:20Z","timestamp":1778151140170,"version":"3.51.4"},"reference-count":59,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The characterization of the metabolites accumulated in the grapes of specific cultivars grown in different climates is of particular importance for viticulturists and enologists. In the present study, the metabolite profiling of grapes from the cultivars, Alvarinho, Arinto and Padeiro de Basto, of two Portuguese Controlled Denomination of Origin (DOC) regions (Vinho Verde and Lisboa) was investigated by gas chromatography-coupled time-of-flight mass spectrometry (GC-TOF-MS) and an amino acid analyzer. Primary metabolites, including sugars, organic acids and amino acids, and some secondary metabolites were identified. Tartaric and malic acids and free amino acids accumulated more in grapes from vines of the DOC region of Vinho Verde than DOC Lisboa, but a principal component analysis (PCA) plot showed that besides the DOC region, the grape cultivar also accounted for the variance in the relative abundance of metabolites. Grapes from the cultivar, Alvarinho, were particularly rich in malic acid and tartaric acids in both DOC regions, but sucrose accumulated more in the DOC region of Vinho Verde.<\/jats:p>","DOI":"10.3390\/ijms15034237","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T07:29:49Z","timestamp":1394436589000},"page":"4237-4254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The First Insight into the Metabolite Profiling of Grapes from Three Vitis vinifera L. Cultivars of Two Controlled Appellation (DOC) Regions"],"prefix":"10.3390","volume":"15","author":[{"given":"Ant\u00f3nio","family":"Teixeira","sequence":"first","affiliation":[{"name":"Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Quinta de Prados, Vila Real 5001-801, Portugal"},{"name":"Research Group in Applied Plant Biology and Innovation in Agrofood-Agrobioplant,  Department of Biology, School of Sciences, University of Minho, Campus de Gualtar,  Braga 4710-057, Portugal"}]},{"given":"Viviana","family":"Martins","sequence":"additional","affiliation":[{"name":"Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Quinta de Prados, Vila Real 5001-801, Portugal"},{"name":"Research Group in Applied Plant Biology and Innovation in Agrofood-Agrobioplant,  Department of Biology, School of Sciences, University of Minho, Campus de Gualtar,  Braga 4710-057, Portugal"}]},{"given":"Henrique","family":"Noronha","sequence":"additional","affiliation":[{"name":"Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Quinta de Prados, Vila Real 5001-801, Portugal"},{"name":"Research Group in Applied Plant Biology and Innovation in Agrofood-Agrobioplant,  Department of Biology, School of Sciences, University of Minho, Campus de Gualtar,  Braga 4710-057, Portugal"}]},{"given":"Jos\u00e9","family":"Eiras-Dias","sequence":"additional","affiliation":[{"name":"National Institute of Agrarian and Veterinary Research (INIAV), Quinta da Almoinha,  Dois Portos 2565-191, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-4095","authenticated-orcid":false,"given":"Hern\u00e2ni","family":"Ger\u00f3s","sequence":"additional","affiliation":[{"name":"Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Quinta de Prados, Vila Real 5001-801, Portugal"},{"name":"Research Group in Applied Plant Biology and Innovation in Agrofood-Agrobioplant,  Department of Biology, School of Sciences, University of Minho, Campus de Gualtar,  Braga 4710-057, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ngeo429","article-title":"Land and wine","volume":"2","author":"White","year":"2009","journal-title":"Nat. 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