{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:27:41Z","timestamp":1770442061833,"version":"3.49.0"},"reference-count":101,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/AGR-PRO\/119058\/2010"],"award-info":[{"award-number":["PTDC\/AGR-PRO\/119058\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/80073\/2011"],"award-info":[{"award-number":["SFRH\/BPD\/80073\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/81830\/2011"],"award-info":[{"award-number":["SFRH\/BPD\/81830\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Serine\/arginine-rich (SR) proteins are major modulators of alternative splicing,  a key generator of proteomic diversity and flexible means of regulating gene expression likely to be crucial in plant environmental responses. Indeed, mounting evidence implicates splicing factors in signal transduction of the abscisic acid (ABA) phytohormone, which  plays pivotal roles in the response to various abiotic stresses. Using real-time RT-qPCR,  we analyzed total steady-state transcript levels of the 18 SR and two SR-like genes from Arabidopsis thaliana in seedlings treated with ABA and in genetic backgrounds with altered expression of the ABA-biosynthesis ABA2 and the ABA-signaling ABI1 and ABI4 genes. We also searched for ABA-responsive cis elements in the upstream regions of the 20 genes. We found that members of the plant-specific SC35-Like (SCL) Arabidopsis SR protein subfamily are distinctively responsive to exogenous ABA, while the expression of seven SR and SR-related genes is affected by alterations in key components of the ABA pathway. Finally, despite pervasiveness of established ABA-responsive promoter elements in Arabidopsis SR and SR-like genes, their expression is likely governed by additional, yet unidentified cis-acting elements. Overall, this study pinpoints SR34, SR34b, SCL30a, SCL28, SCL33, RS40, SR45 and SR45a as promising candidates for involvement in ABA-mediated stress responses.     <\/jats:p>","DOI":"10.3390\/ijms151017541","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T11:16:45Z","timestamp":1411989405000},"page":"17541-17564","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Abscisic Acid (ABA) Regulation of Arabidopsis SR Protein  Gene Expression"],"prefix":"10.3390","volume":"15","author":[{"given":"Tiago","family":"Cruz","sequence":"first","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, Oeiras 2780-156, Portugal"}]},{"given":"Raquel","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, Oeiras 2780-156, Portugal"}]},{"given":"Dale","family":"Richardson","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, Oeiras 2780-156, Portugal"}]},{"given":"Paula","family":"Duque","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, Oeiras 2780-156, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2014,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/978-0-387-77374-2_12","article-title":"The coupling of alternative splicing and nonsense-mediated mRNA decay","volume":"623","author":"Lareau","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-0-387-77374-2_7","article-title":"SR proteins and related factors in alternative splicing","volume":"623","author":"Lin","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1101\/gad.1934910","article-title":"A rational nomenclature for serine\/arginine-rich protein splicing factors (SR proteins)","volume":"24","author":"Manley","year":"2010","journal-title":"Genes Dev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"R6","DOI":"10.1016\/S0960-9822(99)80032-3","article-title":"SR proteins are \u201clocators\u201d of the RNA splicing machinery","volume":"9","author":"Graveley","year":"1999","journal-title":"Curr. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0079-6603(04)78002-2","article-title":"Broad specificity of SR (serine\/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA","volume":"78","author":"Bourgeois","year":"2004","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/368119a0","article-title":"Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors","volume":"368","author":"Kohtz","year":"1994","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/BJ20081501","article-title":"The SR protein family of splicing factors: Master regulators of gene expression","volume":"417","author":"Long","year":"2009","journal-title":"Biochem. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.molcel.2005.02.020","article-title":"SRprises along a messenger\u2019s journey","volume":"17","author":"Huang","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molcel.2010.02.021","article-title":"A splicing-independent function of SF2\/ASF in microRNA processing","volume":"38","author":"Wu","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2009.06.016","article-title":"SR proteins in vertical integration of gene expression from transcription to RNA processing to translation","volume":"35","author":"Zhong","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1105\/tpc.110.078352","article-title":"Implementing a rational and consistent nomenclature for serine\/arginine-rich protein splicing factors (SR proteins) in plants","volume":"22","author":"Barta","year":"2010","journal-title":"Plant Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1023\/A:1006129615846","article-title":"A novel family of plant splicing factors with a Zn knuckle motif: Examination of RNA binding and splicing activities","volume":"39","author":"Lopato","year":"1999","journal-title":"Plant Mol. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e471","DOI":"10.1371\/journal.pone.0000471","article-title":"Regulation of plant developmental processes by a novel splicing factor","volume":"2","author":"Ali","year":"2007","journal-title":"PLoS One"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1101\/gad.13.8.987","article-title":"atSRp30, one of two SF2\/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes","volume":"13","author":"Lopato","year":"1999","journal-title":"Genes Dev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1091\/mbc.e03-02-0109","article-title":"Ectopic expression of atRSZ33 reveals its function in splicing and causes pleiotropic changes in development","volume":"14","author":"Kalyna","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1104\/pp.110.155523","article-title":"The plant-specific SR45 protein negatively regulates glucose and ABA signaling during early seedling development in Arabidopsis","volume":"154","author":"Carvalho","year":"2010","journal-title":"Plant Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1003875","DOI":"10.1371\/journal.pgen.1003875","article-title":"A KH-domain RNA-binding protein interacts with FIERY2\/CTD phosphatase-like 1 and splicing factors and is important for pre-mRNA splicing in Arabidopsis","volume":"9","author":"Chen","year":"2013","journal-title":"PLoS Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1365-313X.2007.03392.x","article-title":"Monitoring changes in alternative precursor messenger RNA splicing in multiple gene transcripts","volume":"53","author":"Simpson","year":"2008","journal-title":"Plant J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Thomas, J., Palusa, S.G., Prasad, K.V., Ali, G.S., Surabhi, G.K., Ben-Hur, A., Abdel-Ghany, S.E., and Reddy, A.S. (2012). Identification of an intronic splicing regulatory element involved in auto-regulation of alternative splicing of SCL33 pre-mRNA. Plant J.","DOI":"10.1111\/tpj.12004"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(91)90157-T","article-title":"Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila","volume":"65","author":"Bell","year":"1991","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1126\/science.283.5399.215","article-title":"A molecular mechanism for electrical tuning of cochlear hair cells","volume":"283","author":"Ramanathan","year":"1999","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07509","article-title":"Alternative isoform regulation in human tissue transcriptomes","volume":"456","author":"Wang","year":"2008","journal-title":"Nature"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing","volume":"40","author":"Pan","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrm3525","article-title":"Alternative splicing: A pivotal step between eukaryotic transcription and translation","volume":"14","author":"Kornblihtt","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbadis.2008.09.017","article-title":"Alternative splicing and disease","volume":"1792","author":"Tazi","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1101\/gr.106120.110","article-title":"Function annotation of the rice transcriptome at single-nucleotide resolution by RNA-seq","volume":"20","author":"Lu","year":"2010","journal-title":"Genome Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"International Barley Genome Sequencing, Consortium (2012). A physical, genetic and functional sequence assembly of the barley genome. Nature, 491, 711\u2013716.","DOI":"10.1038\/nature11543"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1101\/gr.134106.111","article-title":"Transcriptome survey reveals increased complexity of the alternative splicing landscape in Arabidopsis","volume":"22","author":"Marquez","year":"2012","journal-title":"Genome Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1105\/tpc.113.113803","article-title":"Alternative splicing at the intersection of biological timing, development, and stress responses","volume":"25","author":"Staiger","year":"2013","journal-title":"Plant Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1105\/tpc.113.117523","article-title":"Complexity of the alternative splicing landscape in plants","volume":"25","author":"Reddy","year":"2013","journal-title":"Plant Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00709-012-0448-9","article-title":"On the physiological significance of alternative splicing events in higher plants","volume":"250","author":"Carvalho","year":"2013","journal-title":"Protoplasma"},{"key":"ref_32","first-page":"257","article-title":"Regulation of alternative splicing of pre-mRNAs by stresses","volume":"326","author":"Ali","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1365-313X.2004.02172.x","article-title":"Intron retention is a major phenomenon in alternative splicing in Arabidopsis","volume":"39","author":"Halachmi","year":"2004","journal-title":"Plant J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tplants.2003.09.001","article-title":"Alternative splicing and proteome diversity in plants: The tip of the iceberg has just emerged","volume":"8","author":"Kazan","year":"2003","journal-title":"Trends Plant Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1101\/gr.093302.109","article-title":"Genome-wide mapping of alternative splicing in Arabidopsis thaliana","volume":"20","author":"Filichkin","year":"2010","journal-title":"Genome Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/1471-2164-15-431","article-title":"Genome-wide analysis of alternative splicing of pre-mRNA under salt stress in Arabidopsis","volume":"15","author":"Ding","year":"2014","journal-title":"BMC Genomics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1093\/nar\/gkh845","article-title":"Genome-wide analysis of alternative pre-mRNA splicing in Arabidopsis thaliana based on full-length cDNA sequences","volume":"32","author":"Iida","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4161\/psb.6.1.14063","article-title":"A role for SR proteins in plant stress responses","volume":"6","author":"Duque","year":"2011","journal-title":"Plant Signal. Behav."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.arplant.58.032806.103754","article-title":"Alternative splicing of pre-messenger RNAs in plants in the genomic era","volume":"58","author":"Reddy","year":"2007","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/j.1365-313X.2006.03020.x","article-title":"Alternative splicing of pre-mRNAs of Arabidopsis serine\/arginine-rich proteins: Regulation by hormones and stresses","volume":"49","author":"Palusa","year":"2007","journal-title":"Plant J."},{"key":"ref_41","first-page":"83","article-title":"Plant SR proteins and their functions","volume":"326","author":"Barta","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/pcp\/pcm069","article-title":"Differential expression of alternatively spliced mRNAs of Arabidopsis SR protein homologs, atSR30 and atSR45a, in response to environmental stress","volume":"48","author":"Tanabe","year":"2007","journal-title":"Plant Cell Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/psb.2.3.4156","article-title":"Abscisic acid and abiotic stress signaling","volume":"2","author":"Tuteja","year":"2007","journal-title":"Plant Signal. Behav."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00299-013-1439-9","article-title":"The root of ABA action in environmental stress response","volume":"32","author":"Hong","year":"2013","journal-title":"Plant Cell Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1146\/annurev-arplant-042809-112122","article-title":"Abscisic acid: Emergence of a core signaling network","volume":"61","author":"Cutler","year":"2010","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1101\/gad.1953910","article-title":"Early abscisic acid signal transduction mechanisms: Newly discovered components and newly emerging questions","volume":"24","author":"Hubbard","year":"2010","journal-title":"Genes Dev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.devcel.2014.04.004","article-title":"A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis","volume":"29","author":"Lumba","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1105\/tpc.110.074674","article-title":"The conserved splicing factor SUA controls alternative splicing of the developmental regulator ABI3 in Arabidopsis","volume":"22","author":"Sugliani","year":"2010","journal-title":"Plant Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/tpj.12491","article-title":"A homolog of splicing factor SF1 is essential for development and is involved in the alternative splicing of pre-mRNA in Arabidopsis thaliana","volume":"78","author":"Jang","year":"2014","journal-title":"Plant J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature00936","article-title":"Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase","volume":"418","author":"Li","year":"2002","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1016\/j.febslet.2006.06.064","article-title":"Arabidopsis RNA-binding protein UBA2a relocalizes into nuclear speckles in response to abscisic acid","volume":"580","author":"Riera","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1093\/pcp\/pcm087","article-title":"A zinc finger-containing glycine-rich RNA-binding protein, atRZ-1a, has a negative impact on seed germination and seedling growth of Arabidopsis thaliana under salt or drought stress conditions","volume":"48","author":"Kim","year":"2007","journal-title":"Plant Cell Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00277130","article-title":"Characterization of the expression of a desiccation-responsive rd29 gene of Arabidopsis thaliana and analysis of its promoter in transgenic plants","volume":"236","author":"Shinozaki","year":"1993","journal-title":"Mol. Gen. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e24542","DOI":"10.1371\/journal.pone.0024542","article-title":"Comparative analysis of serine\/arginine-rich proteins across 27 eukaryotes: Insights into sub-family classification and extent of alternative splicing","volume":"6","author":"Richardson","year":"2011","journal-title":"PLoS One"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/BST0320561","article-title":"A plethora of plant serine\/arginine-rich proteins: Redundancy or evolution of novel gene functions?","volume":"32","author":"Kalyna","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/pcp\/pcn101","article-title":"Arabidopsis transcriptome analysis under drought, cold, high-salinity and ABA treatment conditions using a tiling array","volume":"49","author":"Matsui","year":"2008","journal-title":"Plant Cell Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1365-313X.2009.03835.x","article-title":"Stress-induced changes in the Arabidopsis thaliana transcriptome analyzed using whole-genome tiling arrays","volume":"58","author":"Zeller","year":"2009","journal-title":"Plant J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1104\/pp.109.138180","article-title":"Two alternatively spliced isoforms of the Arabidopsis SR45 protein have distinct roles during normal plant development","volume":"150","author":"Zhang","year":"2009","journal-title":"Plant Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/pcp\/pcr115","article-title":"Identification of alternative splicing events regulated by an Arabidopsis serine\/arginine-like protein, atSR45a, in response to high-light stress using a tiling array","volume":"52","author":"Yoshimura","year":"2011","journal-title":"Plant Cell Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1104\/pp.103.033431","article-title":"When defense pathways collide. The response of Arabidopsis to a combination of drought and heat stress","volume":"134","author":"Rizhsky","year":"2004","journal-title":"Plant Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"37794","DOI":"10.1074\/jbc.M707168200","article-title":"Cytosolic HSP90 regulates the heat shock response that is responsible for heat acclimation in Arabidopsis thaliana","volume":"282","author":"Yamada","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s10265-006-0285-z","article-title":"Gene expression profiles during heat acclimation in Arabidopsis thaliana suspension-culture cells","volume":"119","author":"Lim","year":"2006","journal-title":"J. Plant Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1104\/pp.107.112060","article-title":"Core genome responses involved in acclimation to high temperature","volume":"146","author":"Larkindale","year":"2008","journal-title":"Plant Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3732\/ajb.1100355","article-title":"Mining Arabidopsis thaliana RNA-seq data with Integrated Genome Browser reveals stress-induced alternative splicing of the putative splicing regulator SR45a","volume":"99","author":"Gulledge","year":"2012","journal-title":"Am. J. Bot."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1046\/j.1365-313X.1996.10040655.x","article-title":"Isolation and characterization of abscisic acid-deficient Arabidopsis mutants at two new loci","volume":"10","author":"Gil","year":"1996","journal-title":"Plant J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-313X.2001.2641043.x","article-title":"Impaired sucrose-induction mutants reveal the modulation of sugar-induced starch biosynthetic gene expression by abscisic acid signalling","volume":"26","author":"Rook","year":"2001","journal-title":"Plant J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1105\/tpc.002477","article-title":"The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde","volume":"14","author":"Apostolova","year":"2002","journal-title":"Plant Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1105\/tpc.006494","article-title":"A unique short-chain dehydrogenase\/reductase in Arabidopsis glucose signaling and abscisic acid biosynthesis and functions","volume":"14","author":"Cheng","year":"2002","journal-title":"Plant Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e718","DOI":"10.1371\/journal.pone.0000718","article-title":"An \u201cElectronic Fluorescent Pictograph\u201d browser for exploring and analyzing large-scale biological data sets","volume":"2","author":"Winter","year":"2007","journal-title":"PLoS One"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1399-3054.1984.tb06343.x","article-title":"The isolation and characterization of abscisic-acid insensitive mutants of Arabidopsis thaliana","volume":"61","author":"Koornneef","year":"1984","journal-title":"Physiol. Plant"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1365-313x.2000.00833.x","article-title":"The Arabidopsis sugar-insensitive mutants sis4 and sis5 are defective in abscisic acid synthesis and response","volume":"23","author":"Laby","year":"2000","journal-title":"Plant J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e1003577","DOI":"10.1371\/journal.pgen.1003577","article-title":"ABI4 regulates primary seed dormancy by regulating the biogenesis of abscisic acid and gibberellins in Arabidopsis","volume":"9","author":"Shu","year":"2013","journal-title":"PLoS Genet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/pcp\/pcq156","article-title":"Molecular basis of the core regulatory network in ABA responses: Sensing, signaling and transport","volume":"51","author":"Umezawa","year":"2010","journal-title":"Plant Cell Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1126\/science.7910981","article-title":"Arabidopsis ABA response gene ABI1: Features of a calcium-modulated protein phosphatase","volume":"264","author":"Leung","year":"1994","journal-title":"Science"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tplants.2012.10.004","article-title":"ABI4: Versatile activator and repressor","volume":"18","author":"Wind","year":"2013","journal-title":"Trends Plant Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1242\/jcs.00175","article-title":"Genome-wide gene expression profiling in Arabidopsis thaliana reveals new targets of abscisic acid and largely impaired gene regulation in the abi1-1 mutant","volume":"115","author":"Hoth","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1104\/pp.124.4.1752","article-title":"Regulation and function of the Arabidopsis ABA-insensitive4 gene in seed and abscisic acid response signaling networks","volume":"124","author":"Soderman","year":"2000","journal-title":"Plant Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-313x.2000.00822.x","article-title":"The Arabidopsis SUCROSE UNCOUPLED-6 gene is identical to ABSCISIC ACID INSENSITIVE-4: Involvement of abscisic acid in sugar responses","volume":"23","author":"Huijser","year":"2000","journal-title":"Plant J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1105\/tpc.110.074641","article-title":"ABI4 mediates abscisic acid and cytokinin inhibition of lateral root formation by reducing polar auxin transport in Arabidopsis","volume":"22","year":"2010","journal-title":"Plant Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1105\/tpc.111.090100","article-title":"The transcription factor ABI4 is required for the ascorbic acid-dependent regulation of growth and regulation of jasmonate-dependent defense signaling pathways in Arabidopsis","volume":"23","author":"Kerchev","year":"2011","journal-title":"Plant Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1046\/j.1365-313x.1999.00565.x","article-title":"ACGT-containing abscisic acid response element (ABRE) and coupling element 3 (CE3) are functionally equivalent","volume":"19","author":"Hobo","year":"1999","journal-title":"Plant J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/pcp\/pcf014","article-title":"Experimentally determined sequence requirement of ACGT-containing abscisic acid response element","volume":"43","author":"Hattori","year":"2002","journal-title":"Plant Cell Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-313X.2003.01708.x","article-title":"Interaction between two cis-acting elements, ABRE and DRE, in ABA-dependent expression of Arabidopsis rd29A gene in response to dehydration and high-salinity stresses","volume":"34","author":"Narusaka","year":"2003","journal-title":"Plant J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/1471-2164-8-260","article-title":"Genome-wide analysis of ABA-responsive elements ABRE and CE3 reveals divergent patterns in Arabidopsis and rice","volume":"8","author":"Dreyer","year":"2007","journal-title":"BMC Genomics"},{"key":"ref_85","first-page":"295","article-title":"Functional dissection of an abscisic acid (ABA)-inducible gene reveals two independent ABA-responsive complexes each containing a G-box and a novel cis-acting element","volume":"7","author":"Shen","year":"1995","journal-title":"Plant Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"W202","DOI":"10.1093\/nar\/gkp335","article-title":"MEME SUITE: Tools for motif discovery and searching","volume":"37","author":"Bailey","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/bioinformatics\/btr064","article-title":"FIMO: Scanning for occurrences of a given motif","volume":"27","author":"Grant","year":"2011","journal-title":"Bioinformatics"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: The European Molecular Biology Open Software Suite","volume":"16","author":"Rice","year":"2000","journal-title":"Trends Genet."},{"key":"ref_89","first-page":"1107","article-title":"Modular nature of abscisic acid (ABA) response complexes: Composite promoter units that are necessary and sufficient for ABA induction of gene expression in barley","volume":"8","author":"Shen","year":"1996","journal-title":"Plant Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s11033-012-2250-3","article-title":"Genome-wide identification and analysis of late embryogenesis abundant (LEA) genes in Prunus mume","volume":"40","author":"Du","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10265-011-0412-3","article-title":"ABA-mediated transcriptional regulation in response to osmotic stress in plants","volume":"124","author":"Fujita","year":"2011","journal-title":"J. Plant Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1104\/pp.104.054312","article-title":"Annotations and functional analyses of the rice WRKY gene superfamily reveal positive and negative regulators of abscisic acid signaling in aleurone cells","volume":"137","author":"Xie","year":"2005","journal-title":"Plant Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1093\/jxb\/ers293","article-title":"Cooperation of three WRKY-domain transcription factors WRKY18, WRKY40, and WRKY60 in repressing two ABA-responsive genes ABI4 and ABI5 in Arabidopsis","volume":"63","author":"Liu","year":"2012","journal-title":"J. Exp. Bot."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1365-3040.2005.01477.x","article-title":"Sugar and ABA response pathways and the control of gene expression","volume":"29","author":"Rook","year":"2006","journal-title":"Plant Cell Environ."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-313X.2009.03877.x","article-title":"The Arabidopsis ABA-INSENSITIVE (ABI) 4 factor acts as a central transcription activator of the expression of its own gene, and for the induction of ABI5 and SBE2.2 genes during sugar signaling","volume":"59","author":"Bossi","year":"2009","journal-title":"Plant J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e1004375","DOI":"10.1371\/journal.pgen.1004375","article-title":"Intron retention in the 5'-UTR of the novel ZIF2 transporter enhances translation to promote zinc tolerance in Arabidopsis","volume":"10","author":"Remy","year":"2014","journal-title":"PLoS Genet."},{"key":"ref_97","first-page":"1372","article-title":"Processing of gene expression data generated by quantitative real-time RT-PCR","volume":"32","author":"Muller","year":"2002","journal-title":"Biotechniques"},{"key":"ref_98","first-page":"28","article-title":"Fitting a mixture model by expectation maximization to discover motifs in biopolymers","volume":"2","author":"Bailey","year":"1994","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1469-8137.2009.03065.x","article-title":"Extensive coupling of alternative splicing of pre-mRNAs of serine\/arginine (SR) genes with nonsense-mediated decay","volume":"185","author":"Palusa","year":"2010","journal-title":"New Phytol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1074\/jbc.R700034200","article-title":"Regulation of alternative splicing by reversible protein phosphorylation","volume":"283","author":"Stamm","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/iub.1075","article-title":"Regulating the regulators: Serine\/arginine-rich proteins under scrutiny","volume":"64","author":"Risso","year":"2012","journal-title":"IUBMB Life"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/15\/10\/17541\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:16:26Z","timestamp":1760217386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/15\/10\/17541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,29]]},"references-count":101,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10]]}},"alternative-id":["ijms151017541"],"URL":"https:\/\/doi.org\/10.3390\/ijms151017541","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,29]]}}}