{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:23:52Z","timestamp":1760243032083,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Morphological changes induced by industrial noise (IN) have been experimentally observed in several organs. Histological observations of the coronary arteries showed prominent perivascular tissue and fibrosis among IN-exposed rats. The effects on the small arteries are unknown. Objective: To evaluate the histomorphometric changes induced by IN on rat heart small arteries. Methods: Twenty Wistar rats exposed to IN during a maximum period of seven months and 20 age-matched controls were studied. Hearts were transversely sectioned from ventricular apex to atria and a mid-ventricular fragment was selected for analysis. The histological images were obtained with an optical microscope using 400\u00d7 magnifications. A total of 634 arterial vessels (298 IN-exposed  and 336 controls) were selected. The mean lumen-to-vessel wall (L\/W) and mean vessel  wall-to-perivascular tissue (W\/P) ratios were calculated using image J software. Results: There were no differences between exposed and control animals in their L\/W ratios  (p = 0.687) and time variations in this ratio were non-significant (p = 0.110). In contrast, exposed animals showed lower W\/P ratios than control animals (p &lt; 0.001), with significant time variations (p = 0.004). Conclusions: Industrial noise induced an increase in the perivascular tissue of rat small coronary arteries, with significant development of periarterial fibrosis.<\/jats:p>","DOI":"10.3390\/ijms160510095","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T10:33:04Z","timestamp":1430735584000},"page":"10095-10104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Histomorphometric Evaluation of the Small Coronary Arteries in Rats Exposed to Industrial Noise"],"prefix":"10.3390","volume":"16","author":[{"given":"Ana","family":"Lousinha","sequence":"first","affiliation":[{"name":"Center for Interdisciplinary Research Egas Moniz (CIIEM), Health Sciences Institute,  2829-511 Monte de Caparica, Portugal"}]},{"given":"Eduardo","family":"Antunes","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research Egas Moniz (CIIEM), Health Sciences Institute,  2829-511 Monte de Caparica, Portugal"}]},{"given":"Gon\u00e7alo","family":"Borrecho","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research Egas Moniz (CIIEM), Health Sciences Institute,  2829-511 Monte de Caparica, Portugal"}]},{"given":"Maria","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Abel Salazar Biomedical Sciences Institute, University of Porto,  4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8558-6754","authenticated-orcid":false,"given":"Jos\u00e9","family":"Brito","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research Egas Moniz (CIIEM), Health Sciences Institute,  2829-511 Monte de Caparica, Portugal"}]},{"given":"Jos\u00e9","family":"Santos","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research Egas Moniz (CIIEM), Health Sciences Institute,  2829-511 Monte de Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/1463-1741.50697","article-title":"Chronic exposure of rats to occupational textile noise cause cytological changes in adrenal cortex","volume":"11","author":"Oliveira","year":"2009","journal-title":"Noise Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/AC.68.3.2983417","article-title":"Myocardial fibrosis in rats exposed to low-frequency noise","volume":"68","author":"Antunes","year":"2013","journal-title":"Acta Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/AC.68.3.2983423","article-title":"Histomorphometric evaluation of the coronary artery vessels in rats submitted to industrial noise","volume":"68","author":"Antunes","year":"2013","journal-title":"Acta Cardiol."},{"key":"ref_4","first-page":"1874","article-title":"Immunohistochemical evaluation of cardiac connexin43 in rats exposed to low-frequency noise","volume":"6","author":"Antunes","year":"2013","journal-title":"Int. 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