{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:15:54Z","timestamp":1770437754352,"version":"3.49.0"},"reference-count":63,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The present study aimed to investigate the phytochemical profile of leaf methanol extracts of fourteen Smallanthus sonchifolius (yacon) landraces and their antioxidant, anticholinesterase and antidiabetic activities that could lead to the finding  of more effective agents for the treatment and management of Alzheimer\u2019s disease  and diabetes. For this purpose, antioxidant activity was assessed using different tests:  ferric reducing ability power (FRAP), 2,2-diphenyl-1-picryl hydrazyl (DPPH), nitric oxide (\u02d9NO) and superoxide (O2\u02d9\u2212) scavenging and lipid peroxidation inhibition assays. Anticholinesterase activity was investigated by quantifying the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, whereas antidiabetic activity was investigated by \u03b1-amylase and \u03b1-glucosidase inhibition tests. To understand the contribution of metabolites, phytochemical screening was also performed by high performance liquid chromatography-diode array detector (HPLC-DAD) system. Among all, methanol extract of PER09, PER04 and ECU44 landraces exhibited the highest relative antioxidant capacity index (RACI). ECU44 was found to be rich in 4,5-di-O-caffeoylquinic acid (CQA) and 3,5-di-O-CQA and displayed a good \u03b1-amylase and \u03b1-glucosidase inhibition, showing the lowest IC50 values. Flavonoids, instead, seem to be involved in the AChE and BChE inhibition. The results of this study revealed that the bioactive compound content differences could be determinant for the medicinal properties of this plant especially for antioxidant and antidiabetic activities.<\/jats:p>","DOI":"10.3390\/ijms160817696","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T10:12:24Z","timestamp":1438337544000},"page":"17696-17718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Evaluation of Antioxidant, Antidiabetic and Anticholinesterase Activities of Smallanthus sonchifolius Landraces and Correlation with Their Phytochemical Profiles"],"prefix":"10.3390","volume":"16","author":[{"given":"Daniela","family":"Russo","sequence":"first","affiliation":[{"name":"Department of Science, Basilicata University, 85100 Potenza, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-4396","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Valent\u00e3o","sequence":"additional","affiliation":[{"name":"Rede de Qu\u00edmica e Tecnologia\/Laborat\u00f3rio Associado para a Qu\u00edmica Verde (REQUIMTE\/LAQV), Laborat\u00f3rio de Farmacognosia, Departamento de Qu\u00edmica, Faculdade de Farm\u00e1cia,  Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9764-3920","authenticated-orcid":false,"given":"Paula","family":"Andrade","sequence":"additional","affiliation":[{"name":"Rede de Qu\u00edmica e Tecnologia\/Laborat\u00f3rio Associado para a Qu\u00edmica Verde (REQUIMTE\/LAQV), Laborat\u00f3rio de Farmacognosia, Departamento de Qu\u00edmica, Faculdade de Farm\u00e1cia,  Universidade do Porto, 4050-313 Porto, Portugal"}]},{"given":"Eloy","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences,  Czech University of Life Sciences, 165 21 Prague, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-1237","authenticated-orcid":false,"given":"Luigi","family":"Milella","sequence":"additional","affiliation":[{"name":"Department of Science, Basilicata University, 85100 Potenza, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.17221\/3548-PSE","article-title":"Yacon (Smallanthus sonchifolius (Poeppig & Endlicher) H. 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