{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T12:55:30Z","timestamp":1762520130760,"version":"build-2065373602"},"reference-count":83,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funding for this work was provided by the Portuguese Foundation for Science and Technology (FCT) with co-participation of European Union Fund (FEDER) through the research project UID\/CVT\/00276\/2013."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Post-parturient behavior of mammalian females is essential for early parent\u2013offspring contact. After delivery, lambs need to ingest colostrum for obtaining the related immunological protection, and early interactions between the mother and the lamb are crucial. Despite visual and auditory cues, olfactory cues are decisive in lamb orientation to the mammary gland. In sheep, the inguinal sinus is located bilaterally near the mammary gland as a skin pouch (IGS) that presents a gland that secretes a strong-smelling wax. Sheep IGS gland functions have many aspects under evaluation. The objective of the present study was to evaluate sheep IGS gland functional aspects and mRNA transcription and the protein expression of several hormone receptors, such as progesterone receptor (PGR), estrogen receptor 1 (ESR1), and 2 (ESR2) and prolactin receptor (PRLR) present. In addition, another aim was to achieve information about IGS ultrastructure and chemical compounds produced in this gland. All hormone receptors evaluated show expression in IGS during the estrous cycle (follicular\/luteal phases), pregnancy, and the post-partum period. IGS secretion is rich in triterpenoids that totally differ from the surrounding skin. They might be essential substances for the development of an olfactory preference of newborns to their mothers.<\/jats:p>","DOI":"10.3390\/ijms18071516","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T10:31:57Z","timestamp":1499941917000},"page":"1516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Understanding the Inguinal Sinus in Sheep (Ovis aries)\u2014Morphology, Secretion, and Expression of Progesterone, Estrogens, and Prolactin Receptors"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-4679","authenticated-orcid":false,"given":"Gra\u00e7a","family":"Alexandre-Pires","sequence":"first","affiliation":[{"name":"CIISA-Faculty of Veterinary Medicine (FMV), Universidade de Lisboa, Av. Universidade T\u00e9cnica, 1300-477 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0353-0421","authenticated-orcid":false,"given":"Catarina","family":"Martins","sequence":"additional","affiliation":[{"name":"CEDOC-Chronic Diseases Research Center, Immunology, NOVA Medical School, Universidade Nova de Lisboa, Rua C\u00e2mara Pestana n\u00b0 6, 6-A Edif\u00edcio CEDOC II, 1150-082 Lisboa, Portugal"}]},{"given":"Ant\u00f3nio","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"CIISA-Faculty of Veterinary Medicine (FMV), Universidade de Lisboa, Av. Universidade T\u00e9cnica, 1300-477 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-8455","authenticated-orcid":false,"given":"Margarida","family":"Miranda","sequence":"additional","affiliation":[{"name":"iMed.ULisboa, Pharmacological and Regulatory Sciences Group, Faculty of Pharmacy, Universidade de Lisboa, Av. Gama Pinto, 1649-003 Lisbon, Portugal"}]},{"given":"Olga","family":"Silva","sequence":"additional","affiliation":[{"name":"iMed.ULisboa, Pharmacological and Regulatory Sciences Group, Faculty of Pharmacy, Universidade de Lisboa, Av. Gama Pinto, 1649-003 Lisbon, Portugal"}]},{"given":"D\u00e1rio","family":"Ligeiro","sequence":"additional","affiliation":[{"name":"Centro de Sangue e Transplanta\u00e7\u00e3o de Lisboa, IPST,IP Alameda das Linhas de Torres 117, 1749-005 Lisbon, Portugal"}]},{"given":"Telmo","family":"Nunes","sequence":"additional","affiliation":[{"name":"Microscopy Center, Faculty of Sciences, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Gra\u00e7a","family":"Ferreira-Dias","sequence":"additional","affiliation":[{"name":"CIISA-Faculty of Veterinary Medicine (FMV), Universidade de Lisboa, Av. Universidade T\u00e9cnica, 1300-477 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"ref_1","unstructured":"Brockman, J.H., Snowdon, C., Roper, T., Naguib, M., and Wynne-Eduards, K. (2009). Advances in the Study of Behavior, Elsevier Inc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF00296394","article-title":"Optimality of parental investment: The influence of nursing on reproductive success of mother and female young house mice","volume":"10","author":"Fuchs","year":"1982","journal-title":"Behav. Ecol. 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