{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T14:06:04Z","timestamp":1775829964992,"version":"3.50.1"},"reference-count":125,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BIA-MIC\/1615\/2014 and UID\/BIO\/04565\/2013"],"award-info":[{"award-number":["PTDC\/BIA-MIC\/1615\/2014 and UID\/BIO\/04565\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cystic fibrosis (CF) is the most life-limiting autosomal recessive disorder in Caucasians. CF is characterized by abnormal viscous secretions that impair the function of several tissues, with chronic bacterial airway infections representing the major cause of early decease of these patients. Pseudomonas aeruginosa and bacteria from the Burkholderia cepacia complex (Bcc) are the leading pathogens of CF patients\u2019 airways. A wide array of virulence factors is responsible for the success of infections caused by these bacteria, which have tightly regulated responses to the host environment. Small noncoding RNAs (sRNAs) are major regulatory molecules in these bacteria. Several approaches have been developed to study P. aeruginosa sRNAs, many of which were characterized as being involved in the virulence. On the other hand, the knowledge on Bcc sRNAs remains far behind. The purpose of this review is to update the knowledge on characterized sRNAs involved in P. aeruginosa virulence, as well as to compile data so far achieved on sRNAs from the Bcc and their possible roles on bacteria virulence.<\/jats:p>","DOI":"10.3390\/ijms19123759","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T03:31:33Z","timestamp":1543289493000},"page":"3759","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Small Noncoding Regulatory RNAs from Pseudomonas aeruginosa and Burkholderia cepacia Complex"],"prefix":"10.3390","volume":"19","author":[{"given":"Tiago","family":"Pita","sequence":"first","affiliation":[{"name":"iBB-Institute for Bioengineering and Biosciences, Departmento de Bioengenharia, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, Torre Sul, Piso 6, 1049-001 Lisbon, Portugal"}]},{"given":"Joana R.","family":"Feliciano","sequence":"additional","affiliation":[{"name":"iBB-Institute for Bioengineering and Biosciences, Departmento de Bioengenharia, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, Torre Sul, Piso 6, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-274X","authenticated-orcid":false,"given":"Jorge H.","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"iBB-Institute for Bioengineering and Biosciences, Departmento de Bioengenharia, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, Torre Sul, Piso 6, 1049-001 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF02931326","article-title":"Structure and Functional Properties of Prokaryotic Small Noncoding RNAs","volume":"48","author":"Mikulik","year":"2003","journal-title":"Folia Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-2836(67)90248-3","article-title":"Fractionation of 32P-labelled ribonucleic acids on polyacrylamide gels and their characterization by fingerprinting","volume":"30","author":"Hindley","year":"1967","journal-title":"J. Mol. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.molcel.2011.08.022","article-title":"Regulation by Small RNAs in Bacteria: Expanding Frontiers","volume":"43","author":"Storz","year":"2011","journal-title":"Mol. 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