{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:43:01Z","timestamp":1777502581092,"version":"3.51.4"},"reference-count":353,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\/MCTES (PIDDAC)","award":["UID\/EQU\/00511\/2019 - Laboratory for Process Engineering, Environment, Biotechnology and Energy \u2013 LEPABE"],"award-info":[{"award-number":["UID\/EQU\/00511\/2019 - Laboratory for Process Engineering, Environment, Biotechnology and Energy \u2013 LEPABE"]}]},{"name":"FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionaliza\u00e7\u00e3o (POCI) and by national funds (PIDDAC) through FCT\/MCTES","award":["Project POCI-01-0145-FEDER-006939"],"award-info":[{"award-number":["Project POCI-01-0145-FEDER-006939"]}]},{"name":"Norte Portugal Regional Operational Programme (NORTE 2020), under PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)","award":["Project \u201cLEPABE-2-ECO-INNOVATION\u201d \u2013 NORTE\u201001\u20100145\u2010FEDER\u2010000005"],"award-info":[{"award-number":["Project \u201cLEPABE-2-ECO-INNOVATION\u201d \u2013 NORTE\u201001\u20100145\u2010FEDER\u2010000005"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/129312\/2017"],"award-info":[{"award-number":["SFRH\/BD\/129312\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s Disease (AD) is a neurodegenerative disorder related with the increase of age and it is the main cause of dementia in the world. AD affects cognitive functions, such as memory, with an intensity that leads to several functional losses. The continuous increase of AD incidence demands for an urgent development of effective therapeutic strategies. Despite the extensive research on this disease, only a few drugs able to delay the progression of the disease are currently available. In the last years, several compounds with pharmacological activities isolated from plants, animals and microorganisms, revealed to have beneficial effects for the treatment of AD, targeting different pathological mechanisms. Thus, a wide range of natural compounds may play a relevant role in the prevention of AD and have proven to be efficient in different preclinical and clinical studies. This work aims to review the natural compounds that until this date were described as having significant benefits for this neurological disease, focusing on studies that present clinical trials.<\/jats:p>","DOI":"10.3390\/ijms20092313","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T03:57:07Z","timestamp":1557719827000},"page":"2313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":206,"title":["Natural Compounds for Alzheimer\u2019s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies"],"prefix":"10.3390","volume":"20","author":[{"given":"Stephanie","family":"Andrade","sequence":"first","affiliation":[{"name":"LEPABE, Department of Chemical Engineering, Faculty of Engineering of the University of Porto, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-7520","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Ramalho","sequence":"additional","affiliation":[{"name":"LEPABE, Department of Chemical Engineering, Faculty of Engineering of the University of Porto, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-3967","authenticated-orcid":false,"given":"Joana Ang\u00e9lica","family":"Loureiro","sequence":"additional","affiliation":[{"name":"LEPABE, Department of Chemical Engineering, Faculty of Engineering of the University of Porto, 4200-465 Porto, Portugal"}]},{"given":"Maria do Carmo","family":"Pereira","sequence":"additional","affiliation":[{"name":"LEPABE, Department of Chemical Engineering, Faculty of Engineering of the University of Porto, 4200-465 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bcp.2013.12.024","article-title":"Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers","volume":"88","author":"Reitz","year":"2014","journal-title":"Biochem. 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