{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T20:46:39Z","timestamp":1775421999523,"version":"3.50.1"},"reference-count":108,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Science and Technology Foundation (FCT\/MCT) and European Funds (PRODER\/COMPETE)","award":["M-ERA-NET\/0004\/2015-PAIRED, co-financed by FEDER, under the Partnership Agreement PT2020"],"award-info":[{"award-number":["M-ERA-NET\/0004\/2015-PAIRED, co-financed by FEDER, under the Partnership Agreement PT2020"]}]},{"name":"FCT and Dendropharma - Investiga\u00e7\u00e3o E Servi\u00e7os De Interven\u00e7\u00e3o Farmac\u00eautica, Sociedade Unipessoal Lda","award":["PDE\/00017\/2013"],"award-info":[{"award-number":["PDE\/00017\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.<\/jats:p>","DOI":"10.3390\/ijms21020393","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T03:07:11Z","timestamp":1578539231000},"page":"393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["New Nanotechnologies for the Treatment and Repair of Skin Burns Infections"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"CEB\u2014Centre of Biological Engineering, University of Minho, Campus de Gualtar 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-1981","authenticated-orcid":false,"given":"Andr\u00e9 F.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5610-1052","authenticated-orcid":false,"given":"Maria I.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5306-1996","authenticated-orcid":false,"given":"Maria C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Andrea A. M.","family":"Shimojo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, Campinas 13083-852, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9465-0538","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Soriano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-7890","authenticated-orcid":false,"given":"Beatriz C.","family":"Naveros","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-9107","authenticated-orcid":false,"given":"Alessandra","family":"Durazzo","sequence":"additional","affiliation":[{"name":"CREA\u2014Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy"}]},{"given":"Massimo","family":"Lucarini","sequence":"additional","affiliation":[{"name":"CREA\u2014Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy"}]},{"given":"Selma B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Endocrinology of Hospital de S\u00e3o Jo\u00e3o, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-3327","authenticated-orcid":false,"given":"Antonello","family":"Santini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.addr.2017.08.001","article-title":"Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing","volume":"123","author":"Ghamarypour","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_2","first-page":"511","article-title":"Management of burns","volume":"35","author":"Douglas","year":"2017","journal-title":"Surgery"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.nano.2013.06.002","article-title":"Amphotericin B releasing nanoparticle topical treatment of Candida spp. in the setting of a burn wound","volume":"10","author":"Sanchez","year":"2014","journal-title":"Nanomedicine"},{"key":"ref_4","unstructured":"World Health Organization (2020, January 04). Burns\u2014Key Facts. 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