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The nanocarrier was characterized by Transmission Electron Microscopy (TEM), Fourier-Transform Infrared Spectroscopy (FTIR), X-ray photoelectron spectroscopy, Raman Spectroscopy, and Differential Scanning Calorimetry (DSC). Drug release rates were determined in vitro by the dialysis method. The cytotoxic profile was evaluated using the MTT assay, against a human skin cell line (hFB) as a model for normal cells, and against an adenocarcinomic human alveolar basal epithelial (A569) cell line as a lung cancer in vitro model. The results demonstrated that the functionalization of carbon nanotubes with naringenin occurred by non-covalent interactions. The release profiles demonstrated a pH-responsive behavior, showing a prolonged release in the tumor pH environment. The naringenin-functionalized carbon nanotubes showed lower cytotoxicity on non-malignant cells (hFB) than free naringenin, with an improved anticancer effect on malignant lung cells (A549) as an in vitro model of lung cancer.<\/jats:p>","DOI":"10.3390\/ijms21124557","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T05:28:56Z","timestamp":1593408536000},"page":"4557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Naringenin-Functionalized Multi-Walled Carbon Nanotubes: A Potential Approach for Site-Specific Remote-Controlled Anticancer Delivery for the Treatment of Lung Cancer Cells"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-9365","authenticated-orcid":false,"given":"Renata P.","family":"Morais","sequence":"first","affiliation":[{"name":"Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"},{"name":"Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"}]},{"given":"Gabrielle B.","family":"Novais","sequence":"additional","affiliation":[{"name":"Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"},{"name":"Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"}]},{"given":"Leandro S.","family":"Sangenito","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro (UFRJ), 373, Carlos Chagas Filho Ave, Cidade Universit\u00e1ria da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-8592","authenticated-orcid":false,"given":"Andr\u00e9 L. S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro (UFRJ), 373, Carlos Chagas Filho Ave, Cidade Universit\u00e1ria da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-0405","authenticated-orcid":false,"given":"Ronny","family":"Priefer","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Avenue, Boston, MA 02115, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5511-6105","authenticated-orcid":false,"given":"Margreet","family":"Morsink","sequence":"additional","affiliation":[{"name":"Center for Biomedical Engineering, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA"},{"name":"Translational Liver Research, Department of Medical Cell BioPhysics, Technical Medical Centre, Faculty of Science and Technology, University of Twente, 7522 NB Enschede, The Netherlands"},{"name":"Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, 7522 NB Enschede, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6003-4796","authenticated-orcid":false,"given":"Marcelo C.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"},{"name":"Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Severino","sequence":"additional","affiliation":[{"name":"Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"},{"name":"Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"},{"name":"CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"Tiradentes Institute, 150 Mt Vernon St, Dorchester, MA 02125, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-4144","authenticated-orcid":false,"given":"Juliana C.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"},{"name":"Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farol\u00e2ndia 49032-490, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4103\/atm.ATM_243_17","article-title":"Causes of death in long-term survivors of non-small cell lung cancer: A regional surveillance, epidemiology, and end results study","volume":"13","author":"Kanitkar","year":"2018","journal-title":"J. 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