{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:35:39Z","timestamp":1770834939506,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["722149"],"award-info":[{"award-number":["722149"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001840","name":"Icelandic Centre for Research","doi-asserted-by":"publisher","award":["13049305"],"award-info":[{"award-number":["13049305"]}],"id":[{"id":"10.13039\/501100001840","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005415","name":"H\u00e1sk\u00f3li \u00cdslands","doi-asserted-by":"publisher","award":["Doctoral Grant"],"award-info":[{"award-number":["Doctoral Grant"]}],"id":[{"id":"10.13039\/501100005415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE-1607547 and CHE-1904802"],"award-info":[{"award-number":["CHE-1607547 and CHE-1904802"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Portuguese National Funding Agency for Science Research and Technology (FCT-MCTES)","award":["PTDC\/FIS\u2010AQM\/31215\/2017 and UIDB\/00068\/2020 (CEFITEC)."],"award-info":[{"award-number":["PTDC\/FIS\u2010AQM\/31215\/2017 and UIDB\/00068\/2020 (CEFITEC)."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Platinum coordination complexes have found wide applications as chemotherapeutic anticancer drugs in synchronous combination with radiation (chemoradiation) as well as precursors in focused electron beam induced deposition (FEBID) for nano-scale fabrication. In both applications, low-energy electrons (LEE) play an important role with regard to the fragmentation pathways. In the former case, the high-energy radiation applied creates an abundance of reactive photo- and secondary electrons that determine the reaction paths of the respective radiation sensitizers. In the latter case, low-energy secondary electrons determine the deposition chemistry. In this contribution, we present a combined experimental and theoretical study on the role of LEE interactions in the fragmentation of the Pt(II) coordination compound cis-PtBr2(CO)2. We discuss our results in conjunction with the widely used cancer therapeutic Pt(II) coordination compound cis-Pt(NH3)2Cl2 (cisplatin) and the carbonyl analog Pt(CO)2Cl2, and we show that efficient CO loss through dissociative electron attachment dominates the reactivity of these carbonyl complexes with low-energy electrons, while halogen loss through DEA dominates the reactivity of cis-Pt(NH3)2Cl2.<\/jats:p>","DOI":"10.3390\/ijms22168984","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T08:44:45Z","timestamp":1629449085000},"page":"8984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Low-Energy Electron Interactions in cis-Pt(CO)2Br2 Fragmentation"],"prefix":"10.3390","volume":"22","author":[{"given":"Maicol","family":"Cipriani","sequence":"first","affiliation":[{"name":"Department of Chemistry and Science Institute, University of Iceland, Dunhagi 3, 107 Reykjavik, Iceland"}]},{"given":"Styrmir","family":"Svavarsson","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Science Institute, University of Iceland, Dunhagi 3, 107 Reykjavik, Iceland"}]},{"given":"Filipe","family":"Ferreira da Silva","sequence":"additional","affiliation":[{"name":"CEFITEC, Departamento de F\u00edsica, Faculdade de Ci\u00eancias e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal"}]},{"given":"Hang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-5146","authenticated-orcid":false,"given":"Lisa","family":"McElwee-White","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA"}]},{"given":"Oddur","family":"Ing\u00f3lfsson","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Science Institute, University of Iceland, Dunhagi 3, 107 Reykjavik, Iceland"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semradonc.2005.08.001","article-title":"Biologic Basis for Combining Drugs With Radiation","volume":"16","author":"Wilson","year":"2006","journal-title":"Semin. 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