{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:25:25Z","timestamp":1778289925034,"version":"3.51.4"},"reference-count":98,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Noncommunicable diseases (NCD) and age-associated diseases (AAD) are some of the gravest health concerns worldwide, accounting for up to 70% of total deaths globally. NCD and AAD, such as diabetes, obesity, cardiovascular disease, and cancer, are associated with low-grade chronic inflammation and poor dietary habits. Modulation of the inflammatory status through dietary components is a very appellative approach to fight these diseases and is supported by increasing evidence of natural and dietary components with strong anti-inflammatory activities. The consumption of bioactive lipids has a positive impact on preventing chronic inflammation and consequently NCD and AAD. Thus, new sources of bioactive lipids have been sought out. Microalgae are rich sources of bioactive lipids such as omega-6 and -3 polyunsaturated fatty acids (PUFA) and polar lipids with associated anti-inflammatory activity. PUFAs are enzymatically and non-enzymatically catalyzed to oxylipins and have a significant role in anti and pro-resolving inflammatory responses. Therefore, a large and rapidly growing body of research has been conducted in vivo and in vitro, investigating the potential anti-inflammatory activities of microalgae lipids. This review sought to summarize and critically analyze recent evidence of the anti-inflammatory potential of microalgae lipids and their possible use to prevent or mitigate chronic inflammation.<\/jats:p>","DOI":"10.3390\/ijms22189825","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T21:45:57Z","timestamp":1631483157000},"page":"9825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-3885","authenticated-orcid":false,"given":"Tiago Alexandre","family":"Conde","sequence":"first","affiliation":[{"name":"CESAM-Centre for Environmental and Marine Studies, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Mass Spectrometry Centre, LAQV REQUIMTE, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Department of Medical Sciences, Institute of Biomedicine\u2013iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-950X","authenticated-orcid":false,"given":"Ioannis","family":"Zabetakis","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland"},{"name":"Health Research Institute (HRI), University of Limerick, V94 T9PX Limerick, Ireland"},{"name":"Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0837-9778","authenticated-orcid":false,"given":"Alexandros","family":"Tsoupras","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland"},{"name":"Health Research Institute (HRI), University of Limerick, V94 T9PX Limerick, Ireland"},{"name":"Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland"}]},{"given":"Isabel","family":"Medina","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Marinas-Consejo Superior de Investigaciones Cient\u00edficas (IIM-CSIC), Eduardo Cabello 6, E-36208 Vigo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-8621","authenticated-orcid":false,"given":"Margarida","family":"Costa","sequence":"additional","affiliation":[{"name":"R&D Department, Allmicroalgae Natural Products SAA, Rua 25 de Abril 1974, 2445-287 Pataias, Portugal"}]},{"given":"Joana","family":"Silva","sequence":"additional","affiliation":[{"name":"R&D Department, Allmicroalgae Natural Products SAA, Rua 25 de Abril 1974, 2445-287 Pataias, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-3124","authenticated-orcid":false,"given":"Bruno","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Institute of Biomedicine\u2013iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-7675","authenticated-orcid":false,"given":"Pedro","family":"Domingues","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Centre, LAQV REQUIMTE, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-3601","authenticated-orcid":false,"given":"M. Ros\u00e1rio","family":"Domingues","sequence":"additional","affiliation":[{"name":"CESAM-Centre for Environmental and Marine Studies, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Mass Spectrometry Centre, LAQV REQUIMTE, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpubh.2020.574111","article-title":"Management and Prevention Strategies for Non-communicable Diseases (NCDs) and Their Risk Factors","volume":"8","author":"Budreviciute","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_2","unstructured":"GBD 2016 Causes of Death Collaborators (2017). 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