{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T23:15:25Z","timestamp":1775862925823,"version":"3.50.1"},"reference-count":170,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs\u2019 biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs\u2019 properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.<\/jats:p>","DOI":"10.3390\/ijms23052855","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T20:38:16Z","timestamp":1646599096000},"page":"2855","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6744-0006","authenticated-orcid":false,"given":"Ariana C. F.","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Chemistry & CICECO, Aveiro Institute of Materials, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-7517","authenticated-orcid":false,"given":"Lu\u00eds P. G.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Chemistry & CICECO, Aveiro Institute of Materials, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-7859","authenticated-orcid":false,"given":"Adriana C. C.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Chemistry & CICECO, Aveiro Institute of Materials, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"given":"F\u00e1tima","family":"Martel","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"Department of Biomedicine\u2013Unit of Biochemistry, Faculty of Medicine of Porto, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Teresa M.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Chemistry & CICECO, Aveiro Institute of Materials, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-3160","authenticated-orcid":false,"given":"B\u00e1rbara J. M. Leite","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Chemistry & CICECO, Aveiro Institute of Materials, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/cr400460s","article-title":"Metallodrugs in Medicinal Inorganic Chemistry","volume":"114","author":"Mjos","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"eaaz6992","DOI":"10.1126\/scitranslmed.aaz6992","article-title":"Biology of antimicrobial resistance and approaches to combat it","volume":"12","author":"Schrader","year":"2020","journal-title":"Sci. Transl. 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