{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T19:37:05Z","timestamp":1776368225379,"version":"3.51.2"},"reference-count":80,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The permanent exposure to environmental contaminants promoting weight gain (i.e., obesogens) has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline in male fertility and are key players in shaping future health outcomes, not only for those who are directly exposed to them, but also for upcoming generations. It has been hypothesized that obesogens affect male fertility. By using an interdisciplinary strategy, combining in silico, in vitro, in vivo and epidemiological findings, this review aims to contribute to the biological understanding of the molecular transformations induced by obesogens that are the basis of male infertility. Such understanding is shaped by the use of Adverse Outcomes Pathways, a new approach that may shift the paradigm of reproductive toxicology, contributing to the improvement of the diagnosis and management of the adverse effects of obesogens in male fertility.<\/jats:p>","DOI":"10.3390\/ijms23063046","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T12:58:36Z","timestamp":1647003516000},"page":"3046","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Male Infertility in the XXI Century: Are Obesogens to Blame?"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-7414","authenticated-orcid":false,"given":"Ana C. A.","family":"Sousa","sequence":"first","affiliation":[{"name":"Department of Biology, School of Science and Technology, University of \u00c9vora, 7006-554 \u00c9vora, Portugal"},{"name":"Comprehensive Health Research Centre (CHRC), University of \u00c9vora, 7002\u2013554 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-783X","authenticated-orcid":false,"given":"Marco G.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-523 Porto, Portugal"},{"name":"Biotechnology of Animal and Human Reproduction (TechnoSperm), Unit of Cell Biology, Department of Biology, Institute of Food and Agricultural Technology, University of Girona, ES-17003 Girona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-5699","authenticated-orcid":false,"given":"Pedro F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, QOPNA & LAQV, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5610-8024","authenticated-orcid":false,"given":"Branca M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Beira Interior, Rua Marqu\u00eas d\u2019\u00c1vila e Bolama, 6200-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-2051","authenticated-orcid":false,"given":"Lu\u00eds","family":"Rato","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Beira Interior, Rua Marqu\u00eas d\u2019\u00c1vila e Bolama, 6200-001 Covilh\u00e3, Portugal"},{"name":"Health School of the Polytechnic Institute of Guarda, 6300-035 Guarda, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: The Endocrine Society\u2019s Second Scientific Statement on Endocrine-Disrupting Chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. 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