{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:14:09Z","timestamp":1777162449505,"version":"3.51.4"},"reference-count":177,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian Research Council CNPq","award":["475677\/2008-0"],"award-info":[{"award-number":["475677\/2008-0"]}]},{"name":"Brazilian Research Council CNPq","award":["136\/08"],"award-info":[{"award-number":["136\/08"]}]},{"name":"Brazilian Research Council CNPq","award":["PTDC\/MED-NEU\/31395\/2017"],"award-info":[{"award-number":["PTDC\/MED-NEU\/31395\/2017"]}]},{"name":"Brazilian Research Council CNPq","award":["LISBOA-01-0145-FEDER-031395"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-031395"]}]},{"name":"Brazilian Research Council CNPq","award":["PTDC\/MED-NEU\/2382\/2021"],"award-info":[{"award-number":["PTDC\/MED-NEU\/2382\/2021"]}]},{"name":"Brazilian Research Council CNPq","award":["UID\/DTP\/04138\/2019-2021"],"award-info":[{"award-number":["UID\/DTP\/04138\/2019-2021"]}]},{"name":"Brazilian Research Council CNPq","award":["HR21-00931"],"award-info":[{"award-number":["HR21-00931"]}]},{"name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa (FAPESPA)","award":["475677\/2008-0"],"award-info":[{"award-number":["475677\/2008-0"]}]},{"name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa (FAPESPA)","award":["136\/08"],"award-info":[{"award-number":["136\/08"]}]},{"name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa (FAPESPA)","award":["PTDC\/MED-NEU\/31395\/2017"],"award-info":[{"award-number":["PTDC\/MED-NEU\/31395\/2017"]}]},{"name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa (FAPESPA)","award":["LISBOA-01-0145-FEDER-031395"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-031395"]}]},{"name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa (FAPESPA)","award":["PTDC\/MED-NEU\/2382\/2021"],"award-info":[{"award-number":["PTDC\/MED-NEU\/2382\/2021"]}]},{"name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa (FAPESPA)","award":["UID\/DTP\/04138\/2019-2021"],"award-info":[{"award-number":["UID\/DTP\/04138\/2019-2021"]}]},{"name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa (FAPESPA)","award":["HR21-00931"],"award-info":[{"award-number":["HR21-00931"]}]},{"name":"Funda\u00e7\u00e3o de Amparo e Desenvolvimento da Pesquisa (FADESP)","award":["475677\/2008-0"],"award-info":[{"award-number":["475677\/2008-0"]}]},{"name":"Funda\u00e7\u00e3o de Amparo e Desenvolvimento da Pesquisa (FADESP)","award":["136\/08"],"award-info":[{"award-number":["136\/08"]}]},{"name":"Funda\u00e7\u00e3o de Amparo e Desenvolvimento da Pesquisa (FADESP)","award":["PTDC\/MED-NEU\/31395\/2017"],"award-info":[{"award-number":["PTDC\/MED-NEU\/31395\/2017"]}]},{"name":"Funda\u00e7\u00e3o de Amparo e Desenvolvimento da Pesquisa (FADESP)","award":["LISBOA-01-0145-FEDER-031395"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-031395"]}]},{"name":"Funda\u00e7\u00e3o de Amparo e Desenvolvimento da Pesquisa (FADESP)","award":["PTDC\/MED-NEU\/2382\/2021"],"award-info":[{"award-number":["PTDC\/MED-NEU\/2382\/2021"]}]},{"name":"Funda\u00e7\u00e3o de Amparo e Desenvolvimento da Pesquisa (FADESP)","award":["UID\/DTP\/04138\/2019-2021"],"award-info":[{"award-number":["UID\/DTP\/04138\/2019-2021"]}]},{"name":"Funda\u00e7\u00e3o de Amparo e Desenvolvimento da Pesquisa (FADESP)","award":["HR21-00931"],"award-info":[{"award-number":["HR21-00931"]}]},{"name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o (PROPESP\/UFPA)","award":["475677\/2008-0"],"award-info":[{"award-number":["475677\/2008-0"]}]},{"name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o (PROPESP\/UFPA)","award":["136\/08"],"award-info":[{"award-number":["136\/08"]}]},{"name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o (PROPESP\/UFPA)","award":["PTDC\/MED-NEU\/31395\/2017"],"award-info":[{"award-number":["PTDC\/MED-NEU\/31395\/2017"]}]},{"name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o (PROPESP\/UFPA)","award":["LISBOA-01-0145-FEDER-031395"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-031395"]}]},{"name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o (PROPESP\/UFPA)","award":["PTDC\/MED-NEU\/2382\/2021"],"award-info":[{"award-number":["PTDC\/MED-NEU\/2382\/2021"]}]},{"name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o (PROPESP\/UFPA)","award":["UID\/DTP\/04138\/2019-2021"],"award-info":[{"award-number":["UID\/DTP\/04138\/2019-2021"]}]},{"name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o (PROPESP\/UFPA)","award":["HR21-00931"],"award-info":[{"award-number":["HR21-00931"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)","award":["475677\/2008-0"],"award-info":[{"award-number":["475677\/2008-0"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)","award":["136\/08"],"award-info":[{"award-number":["136\/08"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)","award":["PTDC\/MED-NEU\/31395\/2017"],"award-info":[{"award-number":["PTDC\/MED-NEU\/31395\/2017"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)","award":["LISBOA-01-0145-FEDER-031395"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-031395"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)","award":["PTDC\/MED-NEU\/2382\/2021"],"award-info":[{"award-number":["PTDC\/MED-NEU\/2382\/2021"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)","award":["UID\/DTP\/04138\/2019-2021"],"award-info":[{"award-number":["UID\/DTP\/04138\/2019-2021"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)","award":["HR21-00931"],"award-info":[{"award-number":["HR21-00931"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["475677\/2008-0"],"award-info":[{"award-number":["475677\/2008-0"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["136\/08"],"award-info":[{"award-number":["136\/08"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/MED-NEU\/31395\/2017"],"award-info":[{"award-number":["PTDC\/MED-NEU\/31395\/2017"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["LISBOA-01-0145-FEDER-031395"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-031395"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/MED-NEU\/2382\/2021"],"award-info":[{"award-number":["PTDC\/MED-NEU\/2382\/2021"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UID\/DTP\/04138\/2019-2021"],"award-info":[{"award-number":["UID\/DTP\/04138\/2019-2021"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["HR21-00931"],"award-info":[{"award-number":["HR21-00931"]}]},{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["475677\/2008-0"],"award-info":[{"award-number":["475677\/2008-0"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["136\/08"],"award-info":[{"award-number":["136\/08"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["PTDC\/MED-NEU\/31395\/2017"],"award-info":[{"award-number":["PTDC\/MED-NEU\/31395\/2017"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["LISBOA-01-0145-FEDER-031395"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-031395"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["PTDC\/MED-NEU\/2382\/2021"],"award-info":[{"award-number":["PTDC\/MED-NEU\/2382\/2021"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["UID\/DTP\/04138\/2019-2021"],"award-info":[{"award-number":["UID\/DTP\/04138\/2019-2021"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["HR21-00931"],"award-info":[{"award-number":["HR21-00931"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>As aging and cognitive decline progresses, the impact of a sedentary lifestyle on the appearance of environment-dependent cellular morphologies in the brain becomes more apparent. Sedentary living is also associated with poor oral health, which is known to correlate with the rate of cognitive decline. Here, we will review the evidence for the interplay between mastication and environmental enrichment and assess the impact of each on the structure of the brain. In previous studies, we explored the relationship between behavior and the morphological features of dentate gyrus glial fibrillary acidic protein (GFAP)-positive astrocytes during aging in contrasting environments and in the context of induced masticatory dysfunction. Hierarchical cluster and discriminant analysis of GFAP-positive astrocytes from the dentate gyrus molecular layer revealed that the proportion of AST1 (astrocyte arbors with greater complexity phenotype) and AST2 (lower complexity) are differentially affected by environment, aging and masticatory dysfunction, but the relationship is not straightforward. Here we re-evaluated our previous reconstructions by comparing dorsal and ventral astrocyte morphologies in the dentate gyrus, and we found that morphological complexity was the variable that contributed most to cluster formation across the experimental groups. In general, reducing masticatory activity increases astrocyte morphological complexity, and the effect is most marked in the ventral dentate gyrus, whereas the effect of environment was more marked in the dorsal dentate gyrus. All morphotypes retained their basic structural organization in intact tissue, suggesting that they are subtypes with a non-proliferative astrocyte profile. In summary, the increased complexity of astrocytes in situations where neuronal loss and behavioral deficits are present is counterintuitive, but highlights the need to better understand the role of the astrocyte in these conditions.<\/jats:p>","DOI":"10.3390\/ijms23116342","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T10:08:24Z","timestamp":1654510104000},"page":"6342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus"],"prefix":"10.3390","volume":"23","author":[{"given":"Fab\u00edola de Carvalho Chaves de","family":"Siqueira Mendes","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00f5es em Neurodegenera\u00e7\u00e3o e Infec\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas, Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, Universidade Federal do Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"},{"name":"Curso de Medicina, Centro Universit\u00e1rio do Estado do Par\u00e1, Bel\u00e9m 66613-903, PA, Brazil"}]},{"given":"Marina Negr\u00e3o Frota de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00f5es em Neurodegenera\u00e7\u00e3o e Infec\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas, Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, Universidade Federal do Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}]},{"given":"Manoela","family":"Falsoni","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00f5es em Neurodegenera\u00e7\u00e3o e Infec\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas, Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, Universidade Federal do Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}]},{"given":"Marcia Lorena Ferreira","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00f5es em Neurodegenera\u00e7\u00e3o e Infec\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas, Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, Universidade Federal do Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}]},{"given":"Andr\u00e9 Pinheiro Gurgel","family":"Fel\u00edcio","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00f5es em Neurodegenera\u00e7\u00e3o e Infec\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas, Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, Universidade Federal do Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}]},{"given":"Luisa Taynah Vasconcelos Barbosa da","family":"Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00f5es em Neurodegenera\u00e7\u00e3o e Infec\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas, Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, Universidade Federal do Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2755-2801","authenticated-orcid":false,"given":"F\u00e1bio Leite do Amaral","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00f5es em Neurodegenera\u00e7\u00e3o e Infec\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas, Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, Universidade Federal do Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1380-6655","authenticated-orcid":false,"given":"Daniel Clive","family":"Anthony","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-9777","authenticated-orcid":false,"given":"Dora","family":"Brites","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-004 Lisbon, Portugal"},{"name":"Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, 1649-004 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6611-6880","authenticated-orcid":false,"given":"Cristovam Wanderley Pican\u00e7o","family":"Diniz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00f5es em Neurodegenera\u00e7\u00e3o e Infec\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas, Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, Universidade Federal do Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}]},{"given":"Marcia Consentino Kronka","family":"Sosthenes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00f5es em Neurodegenera\u00e7\u00e3o e Infec\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas, Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto, Universidade Federal do Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Latimer, C.S., Searcy, J.L., Bridges, M.T., Brewer, L.D., Popovi\u0107, J., Blalock, E.M., Landfield, P.W., Thibault, O., and Porter, N.M. (2011). Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0026812"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbr.2013.02.009","article-title":"Cessation of voluntary wheel running Increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice","volume":"245","author":"Nishijima","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s40279-019-01186-7","article-title":"The Association of Sedentary Behaviour and Cognitive Function in People Without Dementia: A Coordinated Analysis Across Five Cohort Studies from COSMIC","volume":"50","author":"Maasakkers","year":"2020","journal-title":"Sports Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1177\/0271678X211009382","article-title":"Hemodynamic and structural brain measures in high and low sedentary older adults","volume":"41","author":"Maasakkers","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13195-019-0521-0","article-title":"Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: A longitudinal investigation using the National Alzheimer\u2019s Coordinating Center Uniform Data Set","volume":"11","author":"Puzo","year":"2019","journal-title":"Alzheimers Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/sj.bdj.2017.992","article-title":"Evidence summary: The relationship between oral health and dementia","volume":"223","author":"Daly","year":"2018","journal-title":"Br. Dent. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/joor.12708","article-title":"Oral function of older people with mild cognitive impairment or dementia","volume":"45","author":"Delwel","year":"2018","journal-title":"J. Oral. Rehabil."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.physbeh.2018.02.018","article-title":"Does reduced mastication influence cognitive and systemic health during aging?","volume":"188","author":"Miquel","year":"2018","journal-title":"Physiol. Behav."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Saito, S., Ohi, T., Murakami, T., Komiyama, T., Miyoshi, Y., Endo, K., Satoh, M., Asayama, K., Inoue, R., and Kikuya, M. (2018). Association between tooth loss and cognitive impairment in community-dwelling older Japanese adults: A 4-year prospective cohort study from the Ohasama study. BMC Oral. Health, 18.","DOI":"10.1186\/s12903-018-0602-7"},{"key":"ref_10","first-page":"3493","article-title":"The impact of tooth loss on cognitive function","volume":"26","author":"Ravida","year":"2021","journal-title":"Clin. Oral. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jnr.24745","article-title":"Oral dysfunctions and cognitive impairment\/dementia","volume":"99","author":"Nakamura","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Suzuki, H., Furuya, J., Hidaka, R., Miyajima, S., Matsubara, C., Ohwada, G., Asada, T., Akazawa, C., Sato, Y., and Tohara, H. (2021). Patients with mild cognitive impairment diagnosed at dementia clinic display decreased maximum occlusal force: A cross-sectional study. BMC Oral. Health, 21.","DOI":"10.1186\/s12903-021-02027-8"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"21599","DOI":"10.18632\/aging.203504","article-title":"Association between tooth loss rate and risk of mild cognitive impairment in older adults: A population-based longitudinal study","volume":"13","author":"Xu","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lauritano, D., Moreo, G., Della Vella, F., Di Stasio, D., Carinci, F., Lucchese, A., and Petruzzi, M. (2019). Oral Health Status and Need for Oral Care in an Aging Population: A Systematic Review. Int. J. Env. Res. Public Health, 16.","DOI":"10.3390\/ijerph16224558"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/scd.12375","article-title":"Oral health care for patients with Alzheimer\u2019s disease: An update","volume":"39","author":"Marchini","year":"2019","journal-title":"Spec. Care Dent."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Scambler, S., Curtis, S., Manthorpe, J., Samsi, K., Rooney, Y.M., and Gallagher, J.E. (2021). The mouth and oral health in the field of dementia. Health, 13634593211049891.","DOI":"10.1177\/13634593211049891"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3233\/THC-218013","article-title":"Effects of masticatory exercise on cognitive function in community-dwelling older adults","volume":"29","author":"Kim","year":"2021","journal-title":"Technol. Health Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.7150\/ijms.11911","article-title":"Chewing Maintains Hippocampus-Dependent Cognitive Function","volume":"12","author":"Chen","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.archger.2016.12.006","article-title":"Association between mastication and cognitive status: A systematic review","volume":"70","author":"Tada","year":"2017","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lin, C.S. (2018). Revisiting the link between cognitive decline and masticatory dysfunction. BMC Geriatr., 18.","DOI":"10.1186\/s12877-017-0693-z"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3389\/fphys.2019.00832","article-title":"Masticatory Dysfunction by Extensive Tooth Loss as a Risk Factor for Cognitive Deficit: A Systematic Review and Meta-Analysis","volume":"10","author":"Alvarenga","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Oh, J.K., Wee, J.H., Kim, Y.H., Byun, S.H., and Choi, H.G. (2021). Association between Tooth Loss and Alzheimer\u2019s Disease in a Nested Case-Control Study Based on a National Health Screening Cohort. J. Clin. Med., 10.","DOI":"10.3390\/jcm10173763"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.14336\/AD.2021.0325","article-title":"Neuroplastic Effect of Exercise Through Astrocytes Activation and Cellular Crosstalk","volume":"12","author":"Li","year":"2021","journal-title":"Aging Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuroscience.2013.12.026","article-title":"Environmental enrichment induces neuroplastic changes in middle age female Balb\/c mice and increases the hippocampal levels of BDNF, p-Akt and p-MAPK1\/2","volume":"260","year":"2014","journal-title":"Neuroscience"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Takeda, Y., Oue, H., Okada, S., Kawano, A., Koretake, K., Michikawa, M., Akagawa, Y., and Tsuga, K. (2016). Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice. BMC Neurosci., 17.","DOI":"10.1186\/s12868-016-0319-y"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1177\/0022034517708771","article-title":"Reduced Mastication Impairs Memory Function","volume":"96","author":"Ono","year":"2017","journal-title":"J. Dent. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Piancino, M.G., Tortarolo, A., Polimeni, A., Bramanti, E., and Bramanti, P. (2020). Altered mastication adversely impacts morpho-functional features of the hippocampus: A systematic review on animal studies in three different experimental conditions involving the masticatory function. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237872"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2535\/ofaj.87.135","article-title":"Masticatory function and cognitive function","volume":"87","author":"Kubo","year":"2010","journal-title":"Okajimas Folia Anat. Jpn."},{"key":"ref_29","first-page":"624","article-title":"Occlusion and brain function: Mastication as a prevention of cognitive dysfunction","volume":"37","author":"Ono","year":"2010","journal-title":"J. Oral. Rehabil."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Frota de Almeida, M.N., de Siqueira Mendes, F.e.C., Gurgel Fel\u00edcio, A.P., Falsoni, M., Ferreira de Andrade, M.L., Bento-Torres, J., da Costa Vasconcelos, P.F., Perry, V.H., Pican\u00e7o-Diniz, C.W., and Kronka Sosthenes, M.C. (2012). Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes. BMC Neurosci., 13.","DOI":"10.1186\/1471-2202-13-23"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Mendes, F.e.C., de Almeida, M.N., Fel\u00edcio, A.P., Fadel, A.C., Silva, D.e.J., Borralho, T.G., da Silva, R.P., Bento-Torres, J., Vasconcelos, P.F., and Perry, V.H. (2013). Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice. BMC Neurosci., 14.","DOI":"10.1186\/1471-2202-14-63"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12017-011-8151-0","article-title":"Occlusal disharmony increases amyloid-beta in the rat hippocampus","volume":"13","author":"Ekuni","year":"2011","journal-title":"Neuromol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ekuni, D., Endo, Y., Tomofuji, T., Azuma, T., Irie, K., Kasuyama, K., and Morita, M. (2013). Effects of apoE deficiency and occlusal disharmony on amyloid-beta production and spatial memory in rats. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074966"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bbrc.2022.01.048","article-title":"Occlusal disharmony transiently decrease cognition via cognitive suppressor molecules and partially restores cognitive ability via clearance molecules","volume":"594","author":"Maeshiba","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e12937","DOI":"10.1111\/acel.12937","article-title":"Astrocyte senescence: Evidence and significance","volume":"18","author":"Cohen","year":"2019","journal-title":"Aging Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"766306","DOI":"10.3389\/fnagi.2021.766306","article-title":"Senescence in Primary Rat Astrocytes Induces Loss of the Mitochondrial Membrane Potential and Alters Mitochondrial Dynamics in Cortical Neurons","volume":"13","author":"Montiel","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.4081\/ejh.2021.3249","article-title":"Quantitative, structural and molecular changes in neuroglia of aging mammals: A review","volume":"65","author":"Pannese","year":"2021","journal-title":"Eur. J. Histochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1177\/1073858418780971","article-title":"Aging in the Brain: New Roles of Epigenetics in Cognitive Decline","volume":"24","author":"Barter","year":"2018","journal-title":"Neuroscientist"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s13311-019-00743-2","article-title":"Molecular Signatures of the Aging Brain: Finding the Links Between Genes and Phenotypes","volume":"16","author":"Lupo","year":"2019","journal-title":"Neurotherapeutics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"194491","DOI":"10.1016\/j.bbagrm.2020.194491","article-title":"Transcriptomic landscape, gene signatures and regulatory profile of aging in the human brain","volume":"1863","year":"2020","journal-title":"Biochim. Biophys Acta Gene Regul. Mech."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Diniz, D.G., de Oliveira, M.A., de Lima, C.M., Foro, C.A.R., Sosthenes, M.C.K., Bento-Torres, J., Vasconcelos, P.F.D., Anthony, D.C., and Diniz, C.W.P. (2016). Age, environment, object recognition and morphological diversity of GFAP-immunolabeled astrocytes. Behav. Brain Funct., 12.","DOI":"10.1186\/s12993-016-0111-2"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Maugeri, G., D\u2019Agata, V., Magr\u00ec, B., Roggio, F., Castorina, A., Ravalli, S., Di Rosa, M., and Musumeci, G. (2021). Neuroprotective Effects of Physical Activity via the Adaptation of Astrocytes. Cells, 10.","DOI":"10.3390\/cells10061542"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnagi.2019.00059","article-title":"Astrocyte Heterogeneity: Impact to Brain Aging and Disease","volume":"11","author":"Matias","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e13521","DOI":"10.1111\/acel.13521","article-title":"Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus","volume":"21","author":"Matias","year":"2022","journal-title":"Aging Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4504925","DOI":"10.1155\/2017\/4504925","article-title":"Age and Environment Influences on Mouse Prion Disease Progression: Behavioral Changes and Morphometry and Stereology of Hippocampal Astrocytes","volume":"2017","author":"Sobral","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"703810","DOI":"10.3389\/fncel.2021.703810","article-title":"Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?","volume":"15","author":"Moulson","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Preman, P., Alfonso-Triguero, M., Alberdi, E., Verkhratsky, A., and Arranz, A.M. (2021). Astrocytes in Alzheimer\u2019s Disease: Pathological Significance and Molecular Pathways. Cells, 10.","DOI":"10.20944\/preprints202102.0230.v1"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/bpa.12538","article-title":"Diversity of astroglial responses across human neurodegenerative disorders and brain aging","volume":"27","author":"Ferrer","year":"2017","journal-title":"Brain Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2009.04.007","article-title":"Morphological changes in hippocampal astrocytes induced by environmental enrichment in mice","volume":"1274","author":"Viola","year":"2009","journal-title":"Brain Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00429-012-0500-8","article-title":"Physical exercise increases GFAP expression and induces morphological changes in hippocampal astrocytes","volume":"219","author":"Saur","year":"2014","journal-title":"Brain Struct. Funct."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00429-013-0563-1","article-title":"Letter to Editor about: \u201cPhysical exercise increases GFAP expression and induces morphological changes in hippocampal astrocytes\u201d","volume":"219","author":"Viola","year":"2014","journal-title":"Brain Struct. Funct."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/jnr.24430","article-title":"Exercise induces region-specific remodeling of astrocyte morphology and reactive astrocyte gene expression patterns in male mice","volume":"97","author":"Lundquist","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"a029736","DOI":"10.1101\/cshperspect.a029736","article-title":"On the Run for Hippocampal Plasticity","volume":"8","author":"Cooper","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41583-019-0120-x","article-title":"Environmental enrichment, new neurons and the neurobiology of individuality","volume":"20","author":"Kempermann","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0166-4328(99)00145-X","article-title":"Impairment of spatial memory and changes in astroglial responsiveness following loss of molar teeth in aged SAMP8 mice","volume":"108","author":"Onozuka","year":"2000","journal-title":"Behav. Brain Res."},{"key":"ref_57","first-page":"31","article-title":"Altera\u00e7\u00e3o mastigat\u00f3ria, ambiente enriquecido e envelhecimento: Estudos estereol\u00f3gicos de CA1 do hipocampo de camundongos su\u00ed\u00e7os albinos","volume":"7","author":"Mendes","year":"2016","journal-title":"Rev. Pan-Amaz. Saude."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.physbeh.2015.10.005","article-title":"Zinc deficiency with reduced mastication impairs spatial memory in young adult mice","volume":"152","author":"Kida","year":"2015","journal-title":"Physiol. Behav."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"632216","DOI":"10.3389\/fnins.2021.632216","article-title":"Sedentary Life and Reduced Mastication Impair Spatial Learning and Memory and Differentially Affect Dentate Gyrus Astrocyte Subtypes in the Aged Mice","volume":"15","author":"Diniz","year":"2021","journal-title":"Front Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s41467-019-14198-8","article-title":"Identification of region-specific astrocyte subtypes at single cell resolution","volume":"11","author":"Batiuk","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuron.2017.06.029","article-title":"Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence","volume":"95","author":"Chai","year":"2017","journal-title":"Neuron"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"E1896","DOI":"10.1073\/pnas.1800165115","article-title":"Normal aging induces A1-like astrocyte reactivity","volume":"115","author":"Clarke","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.celrep.2017.12.039","article-title":"The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain","volume":"22","author":"Boisvert","year":"2018","journal-title":"Cell Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/cne.24610","article-title":"Astrocytic changes with aging and Alzheimer\u2019s disease-type pathology in chimpanzees","volume":"527","author":"Munger","year":"2019","journal-title":"J. Comp. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2021.02.012","article-title":"Astrogliosis and episodic memory in late life: Higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer\u2019s disease","volume":"103","author":"Bettcher","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuroscience.2017.05.033","article-title":"Astrocytes in Memory Function: Pioneering Findings and Future Directions","volume":"370","author":"Adamsky","year":"2018","journal-title":"Neuroscience"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1038\/s41467-019-10830-9","article-title":"Astrocytic p38\u03b1 MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory","volume":"10","author":"Navarrete","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"658343","DOI":"10.3389\/fncir.2021.658343","article-title":"Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement","volume":"15","author":"Iwai","year":"2021","journal-title":"Front. Neural. Circuits"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13041-021-00856-w","article-title":"Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1","volume":"14","author":"Sanderson","year":"2021","journal-title":"Mol. Brain."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.neuron.2019.12.026","article-title":"Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity","volume":"105","author":"Corkrum","year":"2020","journal-title":"Neuron"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1038\/s41467-020-17536-3","article-title":"Astrocytes modulate sensory-evoked neuronal network activity","volume":"11","author":"Lines","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e63329","DOI":"10.7554\/eLife.63329","article-title":"Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways","volume":"10","author":"Vaidyanathan","year":"2021","journal-title":"Elife"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1002\/glia.23073","article-title":"Activation of hypothalamic astrocytes suppresses feeding without altering emotional states","volume":"64","author":"Sweeney","year":"2016","journal-title":"Glia"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e57155","DOI":"10.7554\/eLife.57155","article-title":"Activation of astrocytes in hippocampus decreases fear memory through adenosine A","volume":"9","author":"Li","year":"2020","journal-title":"Elife"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1523\/JNEUROSCI.1578-21.2022","article-title":"A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors","volume":"42","author":"Ren","year":"2022","journal-title":"J. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"786293","DOI":"10.3389\/fncir.2021.786293","article-title":"From Synapses to Circuits, Astrocytes Regulate Behavior","volume":"15","author":"Lyon","year":"2021","journal-title":"Front. Neural Circuits"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.neuron.2020.12.008","article-title":"Behaviorally consequential astrocytic regulation of neural circuits","volume":"109","author":"Nagai","year":"2021","journal-title":"Neuron"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1101\/lm.030635.113","article-title":"Long-term exercise is needed to enhance synaptic plasticity in the hippocampus","volume":"20","author":"Patten","year":"2013","journal-title":"Learn Mem."},{"key":"ref_79","first-page":"410","article-title":"Running Changes the Brain: The Long and the Short of It","volume":"32","author":"Vivar","year":"2017","journal-title":"Physiology (Bethesda)"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s12017-008-8028-z","article-title":"Neurogenesis and exercise: Past and future directions","volume":"10","year":"2008","journal-title":"Neuromolecular Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fncel.2018.00177","article-title":"Effects of Voluntary Wheel-Running Types on Hippocampal Neurogenesis and Spatial Cognition in Middle-Aged Mice","volume":"12","author":"Huang","year":"2018","journal-title":"Front. Cell Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41467-017-02748-x","article-title":"Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1172\/JCI74603","article-title":"BAI1 regulates spatial learning and synaptic plasticity in the hippocampus","volume":"125","author":"Zhu","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/hipo.22103","article-title":"Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner","volume":"23","author":"Birch","year":"2013","journal-title":"Hippocampus"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuropharm.2018.03.042","article-title":"Lifelong environmental enrichment in the absence of exercise protects the brain from age-related cognitive decline","volume":"145","author":"Birch","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1460-9568.2010.07296.x","article-title":"Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes","volume":"32","author":"Diniz","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e3637","DOI":"10.21769\/BioProtoc.3637","article-title":"Enriched Environment Procedures for Rodents: Creating a Standardized Protocol for Diverse Enrichment to Improve Consistency across Research Studies","volume":"10","author":"Harland","year":"2020","journal-title":"Bio Protoc."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1101\/lm.2283011","article-title":"Running is the neurogenic and neurotrophic stimulus in environmental enrichment","volume":"18","author":"Kobilo","year":"2011","journal-title":"Learn Mem."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Gr\u00e9goire, C.A., Bonenfant, D., Le Nguyen, A., Aumont, A., and Fernandes, K.J. (2014). Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086237"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Robison, L.S., Francis, N., Popescu, D.L., Anderson, M.E., Hatfield, J., Xu, F., Anderson, B.J., Van Nostrand, W.E., and Robinson, J.K. (2020). Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030843"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tree.2012.05.001","article-title":"Animal personalities: Consequences for ecology and evolution","volume":"27","author":"Wolf","year":"2012","journal-title":"Trends Ecol. Evol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"11937","DOI":"10.1038\/ncomms11937","article-title":"Hypothalamic CRH neurons orchestrate complex behaviours after stress","volume":"7","author":"Daviu","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Kentner, A.C., Speno, A.V., Doucette, J., and Roderick, R.C. (2021). The Contribution of Environmental Enrichment to Phenotypic Variation in Mice and Rats. eNeuro, 8.","DOI":"10.1101\/2020.07.11.198705"},{"key":"ref_94","first-page":"1088","article-title":"Elevated plus maze for mice","volume":"22","author":"Komada","year":"2008","journal-title":"J. Vis. Exp."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.physbeh.2014.05.032","article-title":"Tests of unconditioned anxiety\u2014Pitfalls and disappointments","volume":"135","author":"Ennaceur","year":"2014","journal-title":"Physiol. Behav."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"107323","DOI":"10.1016\/j.nlm.2020.107323","article-title":"Midbrain circuits of novelty processing","volume":"176","author":"Tapper","year":"2020","journal-title":"Neurobiol. Learn Mem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.neubiorev.2015.05.002","article-title":"Short- and long-lasting consequences of novelty, deviance and surprise on brain and cognition","volume":"55","author":"Schomaker","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbr.2013.07.018","article-title":"Environmental enrichment in female rodents: Considerations in the effects on behavior and biochemical markers","volume":"253","author":"Girbovan","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1007\/s11064-020-03102-2","article-title":"Enriched Environment and Social Isolation Affect Cognition Ability via Altering Excitatory and Inhibitory Synaptic Density in Mice Hippocampus","volume":"45","author":"Wang","year":"2020","journal-title":"Neurochem. Res."},{"key":"ref_100","first-page":"7943","article-title":"Association between cognitive health and masticatory conditions: A descriptive study of the national database of the universal healthcare system in Japan","volume":"13","author":"Ni","year":"2021","journal-title":"Aging (Albany N.Y.)"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jdsr.2018.06.001","article-title":"Mastication as a tool to prevent cognitive dysfunctions","volume":"54","author":"Krishnamoorthy","year":"2018","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/idj.12486","article-title":"Mastication as a protective factor of the cognitive decline in adults: A qualitative systematic review","volume":"69","author":"Chuhuaicura","year":"2019","journal-title":"Int. Dent. J."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/ger.12510","article-title":"Oral health and healthy chewing for healthy cognitive ageing: A comprehensive narrative review","volume":"38","author":"Catena","year":"2021","journal-title":"Gerodontology"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"S788","DOI":"10.4103\/jpbs.JPBS_773_20","article-title":"Influence of Dental Prostheses on Cognitive Functioning in Elderly Population: A Systematic Review","volume":"13","author":"Ahmed","year":"2021","journal-title":"J. Pharm. Bioallied. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2220\/biomedres.28.1","article-title":"Influences of reduced masticatory sensory input from soft-diet feeding upon spatial memory\/learning ability in mice","volume":"28","author":"Tsutsui","year":"2007","journal-title":"Biomed. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.archoralbio.2015.10.006","article-title":"Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment","volume":"61","author":"Kondo","year":"2016","journal-title":"Arch. Oral. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/ger.12380","article-title":"Mind your teeth-The relationship between mastication and cognition","volume":"36","author":"Weijenberg","year":"2019","journal-title":"Gerodontology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2535\/ofaj.84.115","article-title":"Duration-dependent effects of the bite-raised condition on hippocampal function in SAMP8 mice","volume":"84","author":"Arakawa","year":"2007","journal-title":"Okajimas Folia Anat. Jpn."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neulet.2006.12.020","article-title":"Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice","volume":"414","author":"Kubo","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neulet.2012.12.004","article-title":"Occlusal disharmony leads to learning deficits associated with decreased cellular proliferation in the hippocampal dentate gyrus of SAMP8 mice","volume":"534","author":"Mori","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1177\/00220345010800121301","article-title":"Occlusal disharmony affects plasma corticosterone and hypothalamic noradrenaline release in rats","volume":"80","author":"Yoshihara","year":"2001","journal-title":"J. Dent. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2535\/ofaj.85.35","article-title":"Malocclusion induces chronic stress","volume":"85","author":"Iinuma","year":"2008","journal-title":"Okajimas Folia Anat. Jpn."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pnpbp.2017.02.006","article-title":"Experimental occlusal disharmony\u2014A promoting factor for anxiety in rats under chronic psychological stress","volume":"75","author":"Tang","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"876409","DOI":"10.1155\/2015\/876409","article-title":"Mastication as a Stress-Coping Behavior","volume":"2015","author":"Kubo","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Azuma, K., Zhou, Q., Niwa, M., and Kubo, K.Y. (2017). Association between Mastication, the Hippocampus, and the HPA Axis: A Comprehensive Review. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081687"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Cait, J., Cait, A., Scott, R.W., Winder, C.B., and Mason, G.J. (2022). Conventional laboratory housing increases morbidity and mortality in research rodents: Results of a meta-analysis. BMC Biol., 20.","DOI":"10.1186\/s12915-021-01184-0"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"294068","DOI":"10.1155\/2015\/294068","article-title":"Chewing prevents stress-induced hippocampal LTD formation and anxiety-related behaviors: A possible role of the dopaminergic system","volume":"2015","author":"Ono","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2018.12.002","article-title":"Involvement of catecholaminergic and GABAAergic mediations in the anxiety-related behavior in long-term powdered diet-fed mice","volume":"124","author":"Yaoita","year":"2019","journal-title":"Neurochem. Int."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.neuroscience.2008.04.057","article-title":"Chewing ameliorates stress-induced suppression of hippocampal long-term potentiation","volume":"154","author":"Ono","year":"2008","journal-title":"Neuroscience"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neures.2009.04.011","article-title":"Chewing rescues stress-suppressed hippocampal long-term potentiation via activation of histamine H1 receptor","volume":"64","author":"Ono","year":"2009","journal-title":"Neurosci. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2018.03.032","article-title":"Short-term mastication after weaning upregulates GABAergic signalling and reduces dendritic spine in thalamus","volume":"498","author":"Ogawa","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jdsr.2018.03.002","article-title":"Uncovering the neural circuitry involved in the stress-attenuation effects of chewing","volume":"54","author":"Sasaguri","year":"2018","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fnins.2019.00107","article-title":"Environmental Impoverishment, Aging, and Reduction in Mastication Affect Mouse Innate Repertoire to Explore Novel Environments and to Assess Risk","volume":"13","author":"Diniz","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.bbr.2016.09.067","article-title":"Physical exercise induces hippocampal neurogenesis and prevents cognitive decline","volume":"317","author":"Ma","year":"2017","journal-title":"Behav. Brain. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"811335","DOI":"10.3389\/fnins.2022.811335","article-title":"Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment","volume":"16","author":"Wang","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.30.051606.094328","article-title":"The medial temporal lobe and recognition memory","volume":"30","author":"Eichenbaum","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11682-018-9988-8","article-title":"Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography","volume":"14","author":"Hiscox","year":"2020","journal-title":"Brain. Imaging Behav."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1093\/cercor\/bhz339","article-title":"Oscillatory Mechanisms of Successful Memory Formation in Younger and Older Adults Are Related to Structural Integrity","volume":"30","author":"Sander","year":"2020","journal-title":"Cereb. Cortex."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.conb.2020.04.009","article-title":"Structural LTP: From synaptogenesis to regulated synapse enlargement and clustering","volume":"63","author":"Harris","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.tins.2014.08.011","article-title":"Synapse rearrangements upon learning: From divergent-sparse connectivity to dedicated sub-circuits","volume":"37","author":"Caroni","year":"2014","journal-title":"Trends Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.neuroimage.2019.01.061","article-title":"Involvement of hippocampal subfields and anterior-posterior subregions in encoding and retrieval of item, spatial, and associative memories: Longitudinal versus transverse axis","volume":"191","author":"Hrybouski","year":"2019","journal-title":"Neuroimage"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuroscience.2012.01.020","article-title":"Regional dissociation of paradigm-specific synapse remodeling during memory consolidation in the adult rat dentate gyrus","volume":"209","author":"Scully","year":"2012","journal-title":"Neuroscience"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hipo.10037","article-title":"The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation","volume":"13","author":"Miettinen","year":"2003","journal-title":"Hippocampus"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/hipo.23145","article-title":"Neurons and networks in the entorhinal cortex: A reappraisal of the lateral and medial entorhinal subdivisions mediating parallel cortical pathways","volume":"29","author":"Nilssen","year":"2019","journal-title":"Hippocampus"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nn1849","article-title":"Glutamate exocytosis from astrocytes controls synaptic strength","volume":"10","author":"Jourdain","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"13602","DOI":"10.1073\/pnas.1816013116","article-title":"Circuit-specific control of the medial entorhinal inputs to the dentate gyrus by atypical presynaptic NMDARs activated by astrocytes","volume":"116","author":"Savtchouk","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Di Castro, M.A., and Volterra, A. (2021). Astrocyte control of the entorhinal cortex-dentate gyrus circuit: Relevance to cognitive processing and impairment in pathology. Glia.","DOI":"10.1002\/glia.24128"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Akther, S., and Hirase, H. (2021). Assessment of astrocytes as a mediator of memory and learning in rodents. Glia.","DOI":"10.1002\/glia.24099"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnsyn.2020.00010","article-title":"Astrocytic Ephrin-B1 Controls Synapse Formation in the Hippocampus During Learning and Memory","volume":"12","author":"Nguyen","year":"2020","journal-title":"Front. Synaptic Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2020.03.025","article-title":"G-Protein-Coupled Receptors in Astrocyte-Neuron Communication","volume":"456","author":"Kofuji","year":"2021","journal-title":"Neuroscience"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2018.05.002","article-title":"Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement","volume":"174","author":"Adamsky","year":"2018","journal-title":"Cell"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cell.2018.06.023","article-title":"Stimulating Astrocytes to Remember","volume":"174","author":"Covelo","year":"2018","journal-title":"Cell"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1556\/2060.106.2019.04","article-title":"The role of astrocytes on the effects of exercise on episodic memory function","volume":"106","author":"Loprinzi","year":"2019","journal-title":"Physiol. Int."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Pillai, A.G., de Jong, D., Kanatsou, S., Krugers, H., Knapman, A., Heinzmann, J.M., Holsboer, F., Landgraf, R., Jo\u00ebls, M., and Touma, C. (2012). Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038971"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00424-020-02465-3","article-title":"Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain","volume":"473","author":"Verkhratsky","year":"2021","journal-title":"Pflug. Arch"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1002\/pmic.200300456","article-title":"Analysis of glial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer\u2019s disease","volume":"3","author":"Porchet","year":"2003","journal-title":"Proteomics"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fnagi.2020.00148","article-title":"Astrocyte Senescence and Alzheimer\u2019s Disease: A Review","volume":"12","author":"Han","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Morita, M., Ikeshima-Kataoka, H., Kreft, M., Vardjan, N., Zorec, R., and Noda, M. (2019). Metabolic Plasticity of Astrocytes and Aging of the Brain. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040941"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0531-5565(00)00216-3","article-title":"Evidence for involvement of dysfunctional teeth in the senile process in the hippocampus of SAMP8 mice","volume":"36","author":"Watanabe","year":"2001","journal-title":"Exp. Gerontol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0006-8993(01)02410-6","article-title":"Effects of soft-diet feeding on synaptic density in the hippocampus and parietal cortex of senescence-accelerated mice","volume":"902","author":"Yamamoto","year":"2001","journal-title":"Brain Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.brainres.2005.07.038","article-title":"Molarless-induced changes of spines in hippocampal region of SAMP8 mice","volume":"1057","author":"Kubo","year":"2005","journal-title":"Brain Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","article-title":"Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity","volume":"41","author":"Sofroniew","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1523\/JNEUROSCI.3579-16.2017","article-title":"Synaptic Targeting of Double-Projecting Ventral CA1 Hippocampal Neurons to the Medial Prefrontal Cortex and Basal Amygdala","volume":"37","author":"Kim","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1523\/JNEUROSCI.2848-17.2018","article-title":"Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning","volume":"38","author":"Wahlstrom","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/s41467-020-15121-2","article-title":"Encoding of contextual fear memory in hippocampal-amygdala circuit","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.cub.2021.12.024","article-title":"Different encoding of reward location in dorsal and intermediate hippocampus","volume":"32","author":"Jarzebowski","year":"2022","journal-title":"Curr. Biol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.neuroscience.2015.06.029","article-title":"Striking differences in synaptic facilitation along the dorsoventral axis of the hippocampus","volume":"301","author":"Papatheodoropoulos","year":"2015","journal-title":"Neuroscience"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnsyn.2019.00028","article-title":"Gradient of Expression of Dopamine D2 Receptors Along the Dorso-Ventral Axis of the Hippocampus","volume":"11","author":"Dubovyk","year":"2019","journal-title":"Front. Synaptic Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnsyn.2020.00024","article-title":"Dorsal-Ventral Differences in Modulation of Synaptic Transmission in the Hippocampus","volume":"12","author":"Trompoukis","year":"2020","journal-title":"Front. Synaptic Neurosci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/hipo.22820","article-title":"Behavior-driven arc expression is reduced in all ventral hippocampal subfields compared to CA1, CA3, and dentate gyrus in rat dorsal hippocampus","volume":"28","author":"Chawla","year":"2018","journal-title":"Hippocampus"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Frey, S., Schieweck, R., Forn\u00e9, I., Imhof, A., Straub, T., Popper, B., and Kiebler, M.A. (2020). Physical Activity Dynamically Regulates the Hippocampal Proteome along the Dorso-Ventral Axis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103501"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neurobiolaging.2020.12.018","article-title":"Complex and regional-specific changes in the morphological complexity of GFAP","volume":"100","author":"Bondi","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuron.2016.01.011","article-title":"Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior","volume":"89","author":"Bolkan","year":"2016","journal-title":"Neuron"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1038\/npp.2017.56","article-title":"Bidirectional Control of Anxiety-Related Behaviors in Mice: Role of Inputs Arising from the Ventral Hippocampus to the Lateral Septum and Medial Prefrontal Cortex","volume":"42","author":"Parfitt","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"595049","DOI":"10.3389\/fnbeh.2021.595049","article-title":"High-Frequency Stimulation of Ventral CA1 Neurons Reduces Amygdala Activity and Inhibits Fear","volume":"15","author":"Graham","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/hipo.23207","article-title":"Small lesions of the dorsal or ventral hippocampus subregions are associated with distinct impairments in working memory and reference memory retrieval, and combining them attenuates the acquisition rate of spatial reference memory","volume":"30","author":"Hauser","year":"2020","journal-title":"Hippocampus"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.abm7468","article-title":"Adult neurogenesis in neurological diseases","volume":"374","author":"Gage","year":"2021","journal-title":"Science"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1126\/science.abl5163","article-title":"Impact of neurodegenerative diseases on human adult hippocampal neurogenesis","volume":"374","author":"Trinchero","year":"2021","journal-title":"Science"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"594448","DOI":"10.3389\/fnins.2021.594448","article-title":"Adult Hippocampal Neurogenesis and Affective Disorders: New Neurons for Psychic Well-Being","volume":"15","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.legalmed.2006.01.002","article-title":"Correlation between glial fibrillary acidic protein-positive astrocytes and age in the human hippocampus","volume":"8","author":"Takahashi","year":"2006","journal-title":"Leg. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuroscience.2011.02.013","article-title":"Regional and laminar differences in antigen profiles and spatial distributions of astrocytes in the mouse hippocampus, with reference to aging","volume":"180","author":"Jinno","year":"2011","journal-title":"Neuroscience"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neurobiolaging.2013.07.002","article-title":"Complex and region-specific changes in astroglial markers in the aging brain","volume":"35","author":"Yeh","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuroscience.2015.01.007","article-title":"Astrocytes in physiological aging and Alzheimer\u2019s disease","volume":"323","author":"Parpura","year":"2016","journal-title":"Neuroscience"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-981-13-9913-8_7","article-title":"General Pathophysiology of Astroglia","volume":"1175","author":"Verkhratsky","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nlm.2014.04.002","article-title":"Astrocytic plasticity as a possible mediator of the cognitive improvements after environmental enrichment in aged rats","volume":"114","author":"Petrosini","year":"2014","journal-title":"Neurobiol. Learn Mem."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/01621459.1963.10500845","article-title":"Hierarchical Grouping to Optimize an Objective Function","volume":"58","author":"Ward","year":"1963","journal-title":"J. Am. Stat. Assoc."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/11\/6342\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:25:09Z","timestamp":1760138709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/11\/6342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,6]]},"references-count":177,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["ijms23116342"],"URL":"https:\/\/doi.org\/10.3390\/ijms23116342","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,6]]}}}