{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:59:57Z","timestamp":1770728397118,"version":"3.49.0"},"reference-count":122,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","doi-asserted-by":"publisher","award":["PTDC\/BIA-BFS\/0812\/2021"],"award-info":[{"award-number":["PTDC\/BIA-BFS\/0812\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","doi-asserted-by":"publisher","award":["#ANR-17-EURE-0013"],"award-info":[{"award-number":["#ANR-17-EURE-0013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EUR G.E.N.E.","award":["PTDC\/BIA-BFS\/0812\/2021"],"award-info":[{"award-number":["PTDC\/BIA-BFS\/0812\/2021"]}]},{"name":"EUR G.E.N.E.","award":["#ANR-17-EURE-0013"],"award-info":[{"award-number":["#ANR-17-EURE-0013"]}]},{"name":"French Government","award":["PTDC\/BIA-BFS\/0812\/2021"],"award-info":[{"award-number":["PTDC\/BIA-BFS\/0812\/2021"]}]},{"name":"French Government","award":["#ANR-17-EURE-0013"],"award-info":[{"award-number":["#ANR-17-EURE-0013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Animal cells display great diversity in their shape. These morphological characteristics result from crosstalk between the plasma membrane and the force-generating capacities of the cytoskeleton macromolecules. Changes in cell shape are not merely byproducts of cell fate determinants, they also actively drive cell fate decisions, including proliferation and differentiation. Global and local changes in cell shape alter the transcriptional program by a multitude of mechanisms, including the regulation of physical links between the plasma membrane and the nuclear envelope and the mechanical modulation of cation channels and signalling molecules. It is therefore not surprising that anomalies in cell shape contribute to several diseases, including cancer. In this review, we discuss the possibility that the constraints imposed by cell shape determine the behaviour of normal and pro-tumour cells by organizing the whole interconnected regulatory network. In turn, cell behaviour might stabilize cells into discrete shapes. However, to progress towards a fully transformed phenotype and to acquire plasticity properties, pro-tumour cells might need to escape these cell shape restrictions. Thus, robust controls of the cell shape machinery may represent a critical safeguard against carcinogenesis.<\/jats:p>","DOI":"10.3390\/ijms23158622","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T20:52:01Z","timestamp":1659559921000},"page":"8622","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cell Architecture-Dependent Constraints: Critical Safeguards to Carcinogenesis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-417X","authenticated-orcid":false,"given":"Komal","family":"Khalil","sequence":"first","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal"},{"name":"IPATIMUP\u2014Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Dr. Roberto Frias s\/n, 4200-465 Porto, Portugal"},{"name":"Master Programme in Oncology, School of Medicine & Biomedical Sciences, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira 228, 4050-513 Porto, Portugal"}]},{"given":"Alice","family":"Eon","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal"},{"name":"IPATIMUP\u2014Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Dr. Roberto Frias s\/n, 4200-465 Porto, Portugal"},{"name":"Magist\u00e8re Europ\u00e9en de G\u00e9n\u00e9tique, Universit\u00e9 Paris Cit\u00e9, 5 Rue Thomas Mann, 75013 Paris, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-0163","authenticated-orcid":false,"given":"Florence","family":"Janody","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal"},{"name":"IPATIMUP\u2014Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Dr. Roberto Frias s\/n, 4200-465 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1083\/jcb.201612115","article-title":"Transcriptional regulation of cell shape during organ morphogenesis","volume":"217","author":"Sivakumar","year":"2018","journal-title":"J. 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