{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:25:40Z","timestamp":1769084740181,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Palermo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>MASK-air\u00ae, a good practice of the DG Sant\u00e9, has been fully validated in allergic rhinitis, but little is known about its applicability to asthmatics. We explored whether the MASK-air\u00ae application is applicable to patients with severe asthma. Severe asthmatics were proposed to use the MASK-air\u00ae application for 6 months, along with best practice treatment. Treatment of the patients was not changed based on the application results. The evolution of the visual analogue scales (VAS) for asthma, shortness of breath, rhinitis, conjunctivitis, work, and sleep was monitored using MASK-air\u00ae. Adherence to MASK-air\u00ae and to the asthma treatment was also checked. Thirteen patients reported on 1229 days of MASK-air\u00ae use. The average application adherence was 51.8% (range: 19.7\u201398.9%). There was no correlation between application and medication adherence. Highly variably trends were found for the VAS for asthma. Five patients had over 90% well-controlled days, four had well- or moderately controlled asthma (with up to 20% uncontrolled days), one patient had moderately controlled asthma with approximately 20% uncontrolled days, and one patient had 80% uncontrolled days. Highly significant correlations were found for the VAS for asthma, and other patients reported VASs for work, dyspnea, sleep, and rhinitis. MASK-air\u00ae can be used in patients with severe asthma. VAS asthma appears to be an interesting patient-reported outcome highly correlated with dyspnea and impacts on work. Adherence to the application was better than that for rhinitis, but it needs to be improved.<\/jats:p>","DOI":"10.3390\/ijms231911470","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"11470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Applicability of the MASK-Air\u00ae App to Severe Asthma Treated with Biologic Molecules: A Pilot Study"],"prefix":"10.3390","volume":"23","author":[{"given":"Alida","family":"Benfante","sequence":"first","affiliation":[{"name":"PROMISE\u2014Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, University of Palermo, Piazza delle Cliniche n. 2, 90127 Palermo, Italy"}]},{"given":"Bernardo","family":"Sousa-Pinto","sequence":"additional","affiliation":[{"name":"MEDCIDS\u2014Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal"},{"name":"CINTESIS\u2014Center for Health Technology and Services Research, University of Porto, 4200-450 Porto, Portugal"},{"name":"RISE\u2014Health Research Network, University of Porto, 4200-450 Porto, Portugal"}]},{"given":"Gianluca","family":"Pillitteri","sequence":"additional","affiliation":[{"name":"PROMISE\u2014Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, University of Palermo, Piazza delle Cliniche n. 2, 90127 Palermo, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-917X","authenticated-orcid":false,"given":"Salvatore","family":"Battaglia","sequence":"additional","affiliation":[{"name":"PROMISE\u2014Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, University of Palermo, Piazza delle Cliniche n. 2, 90127 Palermo, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0887-8796","authenticated-orcid":false,"given":"Joao","family":"Fonseca","sequence":"additional","affiliation":[{"name":"MEDCIDS\u2014Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal"},{"name":"CINTESIS\u2014Center for Health Technology and Services Research, University of Porto, 4200-450 Porto, Portugal"},{"name":"RISE\u2014Health Research Network, University of Porto, 4200-450 Porto, Portugal"}]},{"given":"Jean","family":"Bousquet","sequence":"additional","affiliation":[{"name":"MACVIA-France, 34000 Montpellier, France"},{"name":"Department of Dermatology and Allergy, Comprehensive Allergy Center, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Humboldt-Universit\u00e4t zu Berlin, 10099 Berlin, Germany"},{"name":"Centre Hospitalier Universitaire, 34295 Montpellier, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6400-6573","authenticated-orcid":false,"given":"Nicola","family":"Scichilone","sequence":"additional","affiliation":[{"name":"PROMISE\u2014Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, University of Palermo, Piazza delle Cliniche n. 2, 90127 Palermo, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1901046","DOI":"10.1183\/13993003.01046-2019","article-title":"GINA 2019: A fundamental change in asthma management: Treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and adolescents","volume":"53","author":"Reddel","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.anai.2016.07.012","article-title":"Telemedicine is as effective as in-person visits for patients with asthma","volume":"117","author":"Portnoy","year":"2016","journal-title":"Ann. 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