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(Portugal)","award":["UIDP\/04046\/2020"],"award-info":[{"award-number":["UIDP\/04046\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["2021"],"award-info":[{"award-number":["2021"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["PD\/BD\/142865\/2018"],"award-info":[{"award-number":["PD\/BD\/142865\/2018"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["CEECIND\/00648\/2017"],"award-info":[{"award-number":["CEECIND\/00648\/2017"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDB\/04077\/2020"],"award-info":[{"award-number":["UIDB\/04077\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDP\/04077\/2020"],"award-info":[{"award-number":["UIDP\/04077\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["OrMagNa\u2014PTDC\/NAN-MAT\/28785\/2017"],"award-info":[{"award-number":["OrMagNa\u2014PTDC\/NAN-MAT\/28785\/2017"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["BioISI\u2014UID\/Multi\/04046\/2019"],"award-info":[{"award-number":["BioISI\u2014UID\/Multi\/04046\/2019"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDB\/04046\/2020"],"award-info":[{"award-number":["UIDB\/04046\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDP\/04046\/2020"],"award-info":[{"award-number":["UIDP\/04046\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancer-related opportunistic bacterial infections are one major barrier for successful clinical therapies, often correlated to the production of genotoxic factors and higher cancer incidence. Although dual anticancer and antimicrobial therapies are a growing therapeutic fashion, they still fall short when it comes to specific delivery and local action in in vivo systems. Nanoparticles are seen as potential therapeutic vectors, be it by means of their intrinsic antibacterial properties and effective delivery capacity, or by means of their repeatedly reported modulation and maneuverability. Herein we report on the production of a biocompatible, antimicrobial magneto-fluorescent nanosystem (NANO3) for the delivery of a dual doxorubicin\u2013ofloxacin formulation against cancer-related bacterial infections. The drug delivery capacity, rendered by its mesoporous silica matrix, is confirmed by the high loading capacity and stimuli-driven release of both drugs, with preference for tumor-like acidic media. The pH-dependent emission of its surface fluorescent SiQDs, provides an insight into NANO3 surface behavior and pore availability, with the SiQDs working as pore gates. Hyperthermia induces heat generation to febrile temperatures, doubling drug release. NANO3-loaded systems demonstrate significant antimicrobial activity, specifically after the application of hyperthermia conditions. NANO3 structure and antimicrobial properties confirm their potential use in a future dual anticancer and antimicrobial therapeutical vector, due to their drug loading capacity and their surface availability for further modification with bioactive, targeting species.<\/jats:p>","DOI":"10.3390\/ijms232012287","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T02:29:46Z","timestamp":1665973786000},"page":"12287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-085X","authenticated-orcid":false,"given":"Gon\u00e7alo A.","family":"Marcelo","sequence":"first","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, FCT NOVA, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-1682","authenticated-orcid":false,"given":"Joana","family":"Galhano","sequence":"additional","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, FCT NOVA, 2829-516 Caparica, Portugal"}]},{"given":"Tiago T.","family":"Robalo","sequence":"additional","affiliation":[{"name":"BioISI-Instituto de Biosistemas e Ci\u00eancias Integrativas, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8152-3054","authenticated-orcid":false,"given":"Maria Margarida","family":"Cruz","sequence":"additional","affiliation":[{"name":"BioISI-Instituto de Biosistemas e Ci\u00eancias Integrativas, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-8589","authenticated-orcid":false,"given":"Mar\u00eda D.","family":"Marcos","sequence":"additional","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico, Universitat Polit\u00e8cnica de Val\u00e8ncia, Universitat de Val\u00e8ncia, 46022 Valencia, Spain"},{"name":"Unidad Mixta UPV-CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Val\u00e8ncia, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46100 Valencia, Spain"},{"name":"CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-9674","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Mart\u00ednez-M\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico, Universitat Polit\u00e8cnica de Val\u00e8ncia, Universitat de Val\u00e8ncia, 46022 Valencia, Spain"},{"name":"Unidad Mixta UPV-CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Val\u00e8ncia, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46100 Valencia, Spain"},{"name":"CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain"}]},{"given":"Maria Paula","family":"Duarte","sequence":"additional","affiliation":[{"name":"Chemistry Department, FCT NOVA, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-8507","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Capelo-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, FCT NOVA, 2829-516 Caparica, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Caparica Campus, 2829-182 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5582-5446","authenticated-orcid":false,"given":"Carlos","family":"Lodeiro","sequence":"additional","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, FCT NOVA, 2829-516 Caparica, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Caparica Campus, 2829-182 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-4820","authenticated-orcid":false,"given":"Elisabete","family":"Oliveira","sequence":"additional","affiliation":[{"name":"BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, FCT NOVA, 2829-516 Caparica, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Caparica Campus, 2829-182 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e46632","DOI":"10.15252\/embr.201846632","article-title":"Bacterial infections and 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