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This finding raised concerns that the recombinant virus might exhibit altered biological properties as compared to the parental viruses and might pose an elevated threat to human health. Here, using pseudotyped particles, we show that ACE2 binding and cell tropism of XD mimics that of BA.1. Further, XD and BA.1 displayed comparable sensitivity to neutralization by antibodies induced upon vaccination with BNT162b2\/Comirnaty (BNT) or BNT vaccination followed by breakthrough infection. Our findings reveal important biological commonalities between XD and Omicron BA.1 host cell entry and its inhibition by antibodies.<\/jats:p>","DOI":"10.3390\/ijms232214057","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T02:28:04Z","timestamp":1668479284000},"page":"14057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-8652","authenticated-orcid":false,"given":"Prerna","family":"Arora","sequence":"first","affiliation":[{"name":"Infection Biology Unit, German Primate Center\u2014Leibniz Institute for Primate Research, Kellnerweg 4, 37077 G\u00f6ttingen, Germany"},{"name":"Faculty of Biology and Psychology, Georg-August-University G\u00f6ttingen, 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Primate Research, Kellnerweg 4, 37077 G\u00f6ttingen, Germany"},{"name":"Faculty of Biology and Psychology, Georg-August-University G\u00f6ttingen, Wilhelmsplatz 1, 37073 G\u00f6ttingen, Germany"}]},{"given":"Inga","family":"Nehlmeier","sequence":"additional","affiliation":[{"name":"Infection Biology Unit, German Primate Center\u2014Leibniz Institute for Primate Research, Kellnerweg 4, 37077 G\u00f6ttingen, Germany"}]},{"given":"Amy","family":"Kempf","sequence":"additional","affiliation":[{"name":"Infection Biology Unit, German Primate Center\u2014Leibniz Institute for Primate Research, Kellnerweg 4, 37077 G\u00f6ttingen, Germany"},{"name":"Faculty of Biology and Psychology, Georg-August-University G\u00f6ttingen, Wilhelmsplatz 1, 37073 G\u00f6ttingen, Germany"}]},{"given":"Anne","family":"Cossmann","sequence":"additional","affiliation":[{"name":"Department for Rheumatology and Immunology, Hannover Medical School, Carl-Neuberg-Stra\u00dfe 1, 30625 Hannover, Germany"}]},{"given":"Gema 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