{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:26:24Z","timestamp":1771493184245,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Council for Scientific and Technological (CNPq)"},{"name":"Research and Technological Innovation Support Foundation of the State of Sergipe (FAPITEC)"},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The Himatanthus genus presents anti-inflammatory, antioxidant activities, suggesting potential wound-healing properties. This study aimed to develop and analyze the wound-healing properties of a photopolymerizable gelatin-based hydrogel (GelMA) containing an ethanolic extract of Himatanthus bracteatus in a murine model. The extract was obtained under high pressure conditions, incorporated (2%) into the GelMA (GelMA-HB), and physically characterized. The anti-inflammatory activity of the extract was assessed using a carrageenan-induced pleurisy model and the GelMA-HB scarring properties in a wound-healing assay. The extract reduced IL-1\u03b2 and TNF-\u03b1 levels (48.5 \u00b1 6.7 and 64.1 \u00b1 4.9 pg\/mL) compared to the vehicle (94.4 \u00b1 2.3 pg\/mL and 106.3 \u00b1 5.7 pg\/mL; p &lt; 0.001). GelMA-HB depicted significantly lower swelling and increased resistance to mechanical compression compared to GelMA (p &lt; 0.05). GelMA-HB accelerated wound closure over the time course of the experiment (p &lt; 0.05) and promoted a significantly greater peak of myofibroblast differentiation (36.1 \u00b1 6.6 cells) and microvascular density (23.1 \u00b1 0.7 microvessels) on day 7 in comparison to GelMA (31.9 \u00b1 5.3 cells and 20.2 \u00b1 0.6 microvessels) and the control (25.8 \u00b1 4.6 cells and 17.5 \u00b1 0.5 microvessels) (p &lt; 0.05). In conclusion, GelMA-HB improved wound healing in rodents, probably by modulating the inflammatory response and myofibroblastic and microvascular differentiation.<\/jats:p>","DOI":"10.3390\/ijms232315176","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T01:42:21Z","timestamp":1670204541000},"page":"15176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Himatanthus bracteatus-Composed In Situ Polymerizable Hydrogel for Wound Healing"],"prefix":"10.3390","volume":"23","author":[{"given":"Bernadeth M.","family":"de Almeida","sequence":"first","affiliation":[{"name":"Biotechnological Postgraduate Program\u2014RENORBIO, Tiradentes University, Aracaju 49010-390, SE, Brazil"}]},{"given":"Izabella D. Dorta","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health and Environment, Tiradentes University, Aracaju 49032-490, SE, Brazil"}]},{"given":"Felipe M. A.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health and Environment, Tiradentes University, Aracaju 49032-490, SE, Brazil"}]},{"given":"Luana C.","family":"Correa","sequence":"additional","affiliation":[{"name":"School of Physiotherapy, Tiradentes University, Aracaju 49032-490, SE, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-8485","authenticated-orcid":false,"given":"John L. S.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Odontology, Paraiba State University, Campina Grande 58429 500, PB, Brazil"}]},{"given":"Claudio","family":"Dariva","sequence":"additional","affiliation":[{"name":"Laboratory for Colloidal Systems Studies, Institute of Technology and Research (ITP), Tiradentes University, Aracaju 49010-390, SE, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patricia","family":"Severino","sequence":"additional","affiliation":[{"name":"Biotechnological Postgraduate Program\u2014RENORBIO, Tiradentes University, Aracaju 49010-390, SE, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-4144","authenticated-orcid":false,"given":"Juliana C.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Biotechnological Postgraduate Program\u2014RENORBIO, Tiradentes University, Aracaju 49010-390, SE, Brazil"},{"name":"Postgraduate Program in Health and Environment, Tiradentes University, Aracaju 49032-490, SE, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Biotechnological Postgraduate Program\u2014RENORBIO, Tiradentes University, Aracaju 49010-390, SE, Brazil"},{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, n\u00ba. 228, 4050-313 Porto, Portugal"},{"name":"REQUIMTE\/UCIBIO, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, n\u00ba. 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-7632","authenticated-orcid":false,"given":"Ricardo L. C.","family":"de Albuquerque-J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Pathology, Federal University of Santa Catarina, Florian\u00f3polis 88040-370, SC, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jcma.2017.11.002","article-title":"Wound healing","volume":"81","author":"Wang","year":"2018","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_2","unstructured":"Wallace, H.A., Basehore, B.M., and Zito, P.M. (2022). Wound Healing Phases. StatPearls, StatPearls Publishing LLC."},{"key":"ref_3","unstructured":"Wernick, B., Nahirniak, P., and Stawicki, S.P. (2022). Impaired Wound Healing. 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