{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:05:13Z","timestamp":1774011913824,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study investigated the phytochemical content of alcoholic extracts and essential oil of a new variety of medicinal plants, Agastache foeniculum (Pursh), which Kuntze adapted for cultivation in Romania, namely \u201cAromat de Buz\u0103u\u201d. The essential oil was investigated by GC-MS, while the identification and quantification of various compounds from alcoholic extracts were performed by HPLC-DAD. The total phenol and flavonoid contents of the extracts were evaluated by using standard phytochemical methods. The antioxidant activities of ethanol, methanol extracts, and essential oil of the plant were also assessed against 2,2\u2032-diphenyl-1-picrylhydrazyl (DPPH\u2022), 2,2\u2032-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS\u2022+), and by ferric reducing power (FRAP) using spectroscopic methods. Cyclic voltammetry was used to evaluate the antioxidant capacity of the essential oil. The concentrations of phenolic compounds were higher in methanolic extract compared to ethanolic extract. A significant correlation was found between total phenol and total flavonoid contents (r = 0.9087). Significant high correlations were also found between the total phenolic compounds and the antioxidant activities of the extracts (r \u2265 0.8600, p &lt; 0.05). In addition, the extracts and essential oil showed good antioxidant and xanthine oxidase inhibitory activities. Estragole was detected as the major constituent of the essential oil (94.89%). The cytotoxic activity of the essential oil was evaluated by the MTT assay. At lower concentrations (1 \u00b5g\/mL) high cytotoxicity against MCF-7 breast cancer cells was observed but not on the non-tumoral dermal fibroblasts (HDF) which indicated selectivity for cancer cells and suggests the presence of biologically active components that contribute to the observed high cytotoxic effect. Findings from the present study offer new perspectives on the use of A. foeniculum as a potential source of bioactive compounds and a good candidate for pharmaceutical plant-based products.<\/jats:p>","DOI":"10.3390\/ijms24010828","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T02:33:21Z","timestamp":1672713201000},"page":"828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bridging the Chemical Profile and Biological Activities of a New Variety of Agastache foeniculum (Pursh) Kuntze Extracts and Essential Oil"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-4218","authenticated-orcid":false,"given":"F\u0103nic\u0103","family":"B\u0103l\u0103nescu","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University of Galati, 35 A.I. Cuza Street, 800010 Galati, Romania"},{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-0102","authenticated-orcid":false,"given":"Andreea Veronica","family":"Botezatu","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-5299","authenticated-orcid":false,"given":"Fernanda","family":"Marques","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia e Ci\u00eancias Nucleares (DECN), Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, University of Lisbon, Campus Tecnol\u00f3gico e Nuclear, Estrada Nacional 10, Km 139.7, Bobadela, 2695-066 Boticas, Portugal"}]},{"given":"Anna","family":"Busuioc","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-3656","authenticated-orcid":false,"given":"Olivian","family":"Marinca\u015f","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat Street, 400293 Cluj-Napoca, Romania"}]},{"given":"Costel","family":"V\u00een\u0103toru","sequence":"additional","affiliation":[{"name":"Plant Genetic Resources Bank for Vegetables, Floriculture, Aromatic and Medicinal Plants Buz\u0103u, 56 Nicolae B\u0103lcescu Street, 120187 Buzau, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-4291","authenticated-orcid":false,"given":"Geta","family":"C\u00e2r\u00e2c","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-5370","authenticated-orcid":false,"given":"Bianca","family":"Furdui","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-0931","authenticated-orcid":false,"given":"Rodica Mihaela","family":"Dinica","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-0-12-817901-7.00002-2","article-title":"Chapter 2\u2014Polyphenols for Skin Cancer: Chemical Properties, Structure-Related Mechanisms of Action and New Delivery Systems","volume":"Volume 63","year":"2019","journal-title":"Bioactive Natural Products"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Khan, T., Ali, M., Khan, A., Nisar, P., Jan, S.A., Afridi, S., and Shinwari, Z.K. 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