{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:07:06Z","timestamp":1777619226227,"version":"3.51.4"},"reference-count":185,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund (ERDF)","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}]},{"name":"Centro 2020 Regional Operational Program","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}]},{"name":"Centro 2020 Regional Operational Program","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"Centro 2020 Regional Operational Program","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"Centro 2020 Regional Operational Program","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}]},{"name":"COMPETE 2020\u2014Operational Programme for Competitiveness and Internationalization","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}]},{"name":"COMPETE 2020\u2014Operational Programme for Competitiveness and Internationalization","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"COMPETE 2020\u2014Operational Programme for Competitiveness and Internationalization","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"COMPETE 2020\u2014Operational Programme for Competitiveness and Internationalization","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}]},{"name":"Portuguese national funds","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}]},{"name":"Portuguese national funds","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}]},{"name":"Portuguese national funds","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}]},{"name":"Portuguese national funds","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>CD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview of what is currently known, we reviewed the literature on human NKT-like cells. NKT-like cells are highly differentiated T cells with \u201cCD1d-independent\u201d antigen recognition and MHC-unrestricted cell killing. The genesis of NKT-like cells is unclear; however, it is proposed that the acquisition of innate characteristics by T cells could represent a remodeling process leading to successful aging. Additionally, it has been shown that NKT-like cells may play a significant role in several pathological conditions, making it necessary to comprehend whether these cells might function as prognostic markers. The quantification and characterization of these cells might serve as a cutting-edge indicator of individual immune health. Additionally, exploring the mechanisms that can control their killing activity in different contexts may therefore result in innovative therapeutic alternatives in a wide range of disease settings.<\/jats:p>","DOI":"10.3390\/ijms24032743","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:52:02Z","timestamp":1675219922000},"page":"2743","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Natural Killer T-like Cells: Immunobiology and Role in Disease"],"prefix":"10.3390","volume":"24","author":[{"given":"Jani-Sofia","family":"Almeida","sequence":"first","affiliation":[{"name":"Institute of Immunology, Faculty of Medicine, University of Coimbra (FMUC), 3004-504 Coimbra, Portugal"},{"name":"Laboratory of Immunology and Oncology, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Centre of Coimbra (CACC), 3000-075 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-0364","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Casanova","sequence":"additional","affiliation":[{"name":"Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Centre of Coimbra (CACC), 3000-075 Coimbra, Portugal"},{"name":"University Clinic of Orthopedics, Orthopedics Service, Tumor Unit of the Locomotor Apparatus (UTAL), Coimbra Hospital and Universitary Center (CHUC), 3000-075 Coimbra, Portugal"}]},{"given":"Manuel","family":"Santos-Rosa","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Faculty of Medicine, University of Coimbra (FMUC), 3004-504 Coimbra, Portugal"},{"name":"Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Centre of Coimbra (CACC), 3000-075 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-6377","authenticated-orcid":false,"given":"Raquel","family":"Tarazona","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Physiology, University of Extremadura, 10003 C\u00e1ceres, Spain"}]},{"given":"Rafael","family":"Solana","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, 14004 C\u00f3rdoba, Spain"},{"name":"Immunology Unit, Department of Cell Biology, Physiology and Immunology, University of C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7519-1620","authenticated-orcid":false,"given":"Paulo","family":"Rodrigues-Santos","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Faculty of Medicine, University of Coimbra (FMUC), 3004-504 Coimbra, Portugal"},{"name":"Laboratory of Immunology and Oncology, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Centre of Coimbra (CACC), 3000-075 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-immunol-031210-101324","article-title":"Natural innate and adaptive immunity to cancer","volume":"29","author":"Vesely","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/jnr.21551","article-title":"NCAM-induced intracelular signaling revisited","volume":"86","author":"Ditlevsen","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"724","DOI":"10.18632\/aging.101774","article-title":"CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age","volume":"11","author":"Devine","year":"2019","journal-title":"Aging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12171","DOI":"10.1038\/ncomms12171","article-title":"Human NK cell development requires CD56-mediated motility and formation of the developmental synapse","volume":"7","author":"Mace","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1399-0039.2011.01714.x","article-title":"Natural killer cell subsets in man and rodents","volume":"78","author":"Inngjerdingen","year":"2011","journal-title":"Tissue Antigens"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3389\/fimmu.2017.00892","article-title":"CD56 in the Immune System: More Than a Marker for Cytotoxicity?","volume":"8","author":"Capsomidis","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.1300111","article-title":"Multiplex and genome-wide analyses reveal distinctive properties of KIR+ and CD56+ T cells in human blood","volume":"191","author":"Chan","year":"2013","journal-title":"J. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ni.3298","article-title":"The burgeoning family of unconventional T cells","volume":"16","author":"Godfrey","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/imr.12576","article-title":"Building conventions for unconventional lymphocytes","volume":"279","author":"Pasman","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/art.22310","article-title":"CD56-expressing T cells that have features of senescence are expanded in rheumatoid arthritis","volume":"56","author":"Michel","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1084\/jem.174.1.139","article-title":"Use of a SCID mouse\/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity","volume":"174","author":"Negrin","year":"1991","journal-title":"J. Exp. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1084\/jem.162.6.2089","article-title":"Functional properties of a unique subset of cytotoxic CD3+ T lymphocytes that express Fc receptors for IgG (CD16\/Leu-11 antigen)","volume":"162","author":"Lanier","year":"1985","journal-title":"J. Exp. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1084\/jem.164.1.351","article-title":"A subset of natural killer cells in peripheral blood displays a mature T cell phenotype","volume":"164","author":"Schmidt","year":"1986","journal-title":"J. Exp. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jaut.2017.06.008","article-title":"CIK as therapeutic agents against tumors","volume":"85","author":"Introna","year":"2017","journal-title":"J. Autoimmun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0047-6374(00)00199-8","article-title":"Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector\/senescente T cells","volume":"121","author":"Tarazona","year":"2000","journal-title":"Mech. Ageing Dev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.exger.2007.05.002","article-title":"Invariant NKT and NKT-like lymphocytes: Two different T cell subsets that are differentially affected by ageing","volume":"42","author":"Peralbo","year":"2007","journal-title":"Exp. Gerontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/intimm\/7.7.1157","article-title":"Predominant expression of invariant V alpha 14+ TCR alpha chain in NK1.1+ T cell populations","volume":"7","author":"Makino","year":"1995","journal-title":"Int. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri1309","article-title":"NKT cells: What\u2019s in a name?","volume":"4","author":"Godfrey","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Torina, A., Guggino, G., La Manna, M.P., and Sireci, G. (2018). The Janus Face of NKT Cell Function in Autoimmunity and Infectious Diseases. Int. J. Mol. Sci., 19.","DOI":"10.20944\/preprints201801.0189.v1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fimmu.2018.00367","article-title":"The Role of Natural Killer T Cells in Cancer-A Phenotypical and Functional Approach","volume":"9","author":"Krijgsman","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ni.1841","article-title":"Raising the NKT cell family","volume":"11","author":"Godfrey","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.4049\/jimmunol.136.12.4480","article-title":"The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes","volume":"136","author":"Lanier","year":"1986","journal-title":"J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.4049\/jimmunol.175.7.4416","article-title":"DX5\/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells","volume":"175","author":"Pellicci","year":"2005","journal-title":"J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/eji.202048941","article-title":"Deep phenotypical characterization of human CD3+ CD56+ T cells by mass cytometry","volume":"51","author":"Schulz","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/joim.12392","article-title":"CD4+ CD56+ natural Killer T-like cells secreting interferon-\u03b3 are associated with incident coronary events","volume":"279","author":"Berg","year":"2016","journal-title":"J. Intern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/0008-8749(91)90369-M","article-title":"Comparative studies of CD3- and CD3+ CD56+ cells: Examination of morphology, functions, T cell receptor rearrangement, and pore-forming protein expression","volume":"136","author":"Ortaldo","year":"1991","journal-title":"Cell. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Eger, K.A., Sundrud, M.S., Motsinger, A.A., Tseng, M., Van Kaer, L., and Unutmaz, D. (2006). Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions. PLoS ONE, 1.","DOI":"10.1371\/journal.pone.0000050"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"717","DOI":"10.7754\/Clin.Lab.2013.130435","article-title":"The aberrant expression of stimulatory and inhibitory killer immunoglobulin-like receptors in NK- and NKT-cells contributes to lupus","volume":"60","author":"Bai","year":"2014","journal-title":"Clin. Lab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12433","DOI":"10.1073\/pnas.93.22.12433","article-title":"Human CD8+ T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations","volume":"93","author":"Mingari","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/87740","article-title":"Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells","volume":"2","author":"Ugolini","year":"2001","journal-title":"Nat. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.4049\/jimmunol.178.9.5524","article-title":"CD56 marks an effector T cell subset in the human intestine","volume":"178","author":"Cohavy","year":"2007","journal-title":"J. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.coi.2014.04.002","article-title":"Shaping of NK cell subsets by aging","volume":"29","author":"Solana","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"14725","DOI":"10.1073\/pnas.1110900108","article-title":"Expansion of a unique CD57\u207aNKG2Chi natural killer cell subset during acute human cytomegalovirus infection","volume":"108","author":"Milush","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"613882","DOI":"10.3389\/fimmu.2020.613882","article-title":"Surface NKG2C Identifies Differentiated \u03b1\u03b2T-Cell Clones Expanded in Peripheral Blood","volume":"11","author":"Kovalenko","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e08409","DOI":"10.1016\/j.heliyon.2021.e08409","article-title":"Phenotypic characterization of NKT-like cells and evaluation of specifically related cytokines for the prediction of unexplained recurrent miscarriage","volume":"7","author":"Khalaf","year":"2021","journal-title":"Heliyon"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-4933-9-23","article-title":"CMV and Immunosenescence: From basics to clinics","volume":"9","author":"Solana","year":"2012","journal-title":"Immun. Ageing"},{"key":"ref_37","first-page":"616","article-title":"Adaptive Memory of Human NK-like CD8+ T-Cells to Aging, and Viral and Tumor Antigens","volume":"7","author":"Pera","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1002\/eji.1830250824","article-title":"Self-reactive T cell clones in a restricted population of interleukin-2 receptor beta+ cells expressing intermediate levels of the T cell receptor in the liver and other immune organs","volume":"25","author":"Kawachi","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1084\/jem.182.3.759","article-title":"Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation","volume":"182","author":"Sato","year":"1995","journal-title":"J. Exp. Med."},{"key":"ref_40","first-page":"556","article-title":"Ontogeny and development of extrathymic T cells in mouse liver","volume":"77","author":"Iiai","year":"1992","journal-title":"Immunology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1046\/j.1365-2567.1996.d01-719.x","article-title":"Cytotoxic activity against tumour cells mediated by intermediate TCR cells in the liver and spleen","volume":"89","author":"Kawamura","year":"1996","journal-title":"Immunology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2567.1997.00240.x","article-title":"Autologous killing by a population of intermediate T-cell receptor cells and its NK1.1+ and NK1.1- subsets, using Faz ligand\/Fas molecules","volume":"91","author":"Moroda","year":"1997","journal-title":"Immunology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/hep.510260208","article-title":"Mouse liver T cells: Their change with aging and in comparison with peripheral T cells","volume":"26","author":"Tsukahara","year":"1997","journal-title":"Hepatology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1365-2249.1994.tb06120.x","article-title":"Increase in the proportion of granulated CD56+ T cells in patients with malignancy","volume":"97","author":"Takii","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-2249.1995.tb06650.x","article-title":"Origin of CD57+ T cells which increase at tumour sites in patients with colorectal cancer","volume":"102","author":"Okada","year":"1995","journal-title":"Clin. Exp. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4049\/jimmunol.164.3.1148","article-title":"Cutting edge: Cytolytic effector function in human circulating CD8+ T cells closely correlates with CD56 surface expression","volume":"164","author":"Pittet","year":"2000","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1348-0421.1994.tb01840.x","article-title":"A similar expression pattern of adhesion molecules between intermediate TCR cells in the liver and intraepithelial lymphocytes in the intestine","volume":"38","author":"Ohtsuka","year":"1994","journal-title":"Microbiol. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.4049\/jimmunol.163.4.2314","article-title":"The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns","volume":"163","author":"Doherty","year":"1999","journal-title":"J. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0198-8859(98)00098-6","article-title":"Natural T cells in the human liver: Cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells","volume":"60","author":"Norris","year":"1999","journal-title":"Hum. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1046\/j.1365-2249.1998.00645.x","article-title":"Expansion of CD56+ NK T and gamma delta T cells from cord blood of human neonates","volume":"113","author":"Musha","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/223472a0","article-title":"Induction of immunological tolerance by porcine liver allografts","volume":"223","author":"Calne","year":"1969","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaut.2015.08.020","article-title":"Immunity, tolerance and autoimmunity in the liver: A comprehensive review","volume":"66","author":"Doherty","year":"2016","journal-title":"J. Autoimmun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"Leaky gut: Mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.3748\/wjg.v13.45.5995","article-title":"Selective decrease in colonic CD56+ T and CD161+ T cells in the inflamed mucosa of patients with ulcerative colitis","volume":"13","author":"Shimamoto","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1002\/1521-4141(200111)31:11<3361::AID-IMMU3361>3.0.CO;2-Z","article-title":"Abundance of unconventional CD8+ natural killer T cells in the large intestine","volume":"31","author":"Bannai","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1046\/j.1365-2249.2002.01886.x","article-title":"CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver","volume":"129","author":"Iiai","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/intimm\/dxh298","article-title":"Human peripheral CD2-\/lo T cells: An extrathymic population of early differentiated, developing T cells","volume":"17","author":"Loza","year":"2005","journal-title":"Int. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1084\/jem.155.1.321","article-title":"Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody","volume":"155","author":"Abo","year":"1982","journal-title":"J. Exp. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/eji.1830140707","article-title":"Characterization of human granular lymphocyte subpopulations expressing HNK-1 (Leu-7) and Leu-11 antigens in the blood and lymphoid tissues from fetuses, neonates and adults","volume":"14","author":"Abo","year":"1984","journal-title":"Eur. J. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1365-2567.2001.01248.x","article-title":"Systematic characterization of human CD8+ T cells with natural killer cell markers in comparison with natural killer cells and normal CD8+ T cells","volume":"103","author":"Ohkawa","year":"2001","journal-title":"Immunology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1023\/A:1027324626199","article-title":"Numerical and functional characteristics of lymphocyte subsets in centenarians","volume":"17","author":"Miyaji","year":"1997","journal-title":"J. Clin. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0531-5565(98)00058-8","article-title":"CD69, CD25, and HLA-DR activation antigen expression on CD3+ lymphocytes and relationship to serum TNF-alpha, IFN-gamma, and sIL-2R levels in aging","volume":"34","author":"Rea","year":"1999","journal-title":"Exp. Gerontol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1365-2567.1999.00738.x","article-title":"CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor","volume":"97","author":"Borrego","year":"1999","journal-title":"Immunology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0531-5565(99)00033-9","article-title":"Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation","volume":"34","author":"Spaulding","year":"1999","journal-title":"Exp. Gerontol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1111\/febs.15770","article-title":"Hallmarks of the aging T-cell system","volume":"288","author":"Zhang","year":"2021","journal-title":"FEBS J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0264-410X(99)00495-8","article-title":"NK and NK\/T cells in human senescence","volume":"18","author":"Solana","year":"2000","journal-title":"Vaccine"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0531-5565(99)00008-X","article-title":"Natural killer cells in healthy aging","volume":"34","author":"Solana","year":"1999","journal-title":"Exp. Gerontol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3389\/fimmu.2016.00530","article-title":"Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging","volume":"7","author":"Michel","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3389\/fimmu.2016.00445","article-title":"Convergence of Innate and Adaptive Immunity during Human Aging","volume":"7","author":"Pereira","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.immuni.2017.03.010","article-title":"Successful and Maladaptive T Cell Aging","volume":"46","author":"Goronzy","year":"2017","journal-title":"Immunity"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.4049\/jimmunol.180.3.1979","article-title":"Induction of CD56 and TCR-independent activation of T cells with aging","volume":"180","author":"Lemster","year":"2008","journal-title":"J. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"231","DOI":"10.5603\/FHC.a2018.0025","article-title":"NKT-like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest seniors","volume":"56","author":"Kaszubowska","year":"2018","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.4049\/jimmunol.138.7.2019","article-title":"Expression of Leu-19 (NKH-1) antigen on IL 2-dependent cytotoxic and non-cytotoxic T cell lines","volume":"138","author":"Lanier","year":"1987","journal-title":"J. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.4049\/jimmunol.167.6.3129","article-title":"Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15","volume":"167","author":"Dunne","year":"2001","journal-title":"J. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12253-018-0444-2","article-title":"IL-2 And IL-15 Induced NKG2D, CD158a and CD158b Expression on T, NKT- like and NK Cell Lymphocyte Subsets from Regional Lymph Nodes of Melanoma Patients","volume":"26","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1089\/107999001753289514","article-title":"Induction of cytotoxic CD8+CD56+ T cells from human thymocytes by interleukin-15","volume":"21","author":"Thulesen","year":"2001","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2249.2004.02586.x","article-title":"Hepatic interleuklin 15 (IL-15) expression: Implications for local NK\/NKT cell homeostasis and development","volume":"138","author":"Kelly","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2141.1994.tb08297.x","article-title":"Propagation of large numbers of T cells with natural killer cell markers","volume":"87","author":"Lefterova","year":"1994","journal-title":"Br. J. Haematol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.biopha.2008.10.003","article-title":"CD137 enhances cytotoxicity of CD3+CD56+ cells and their capacities to induce CD4+ Th1 responses","volume":"63","author":"Zhu","year":"2009","journal-title":"Biomed. Pharmacother."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1182\/blood-2007-11-122259","article-title":"A role for interleukin-12\/23 in the maturation of human natural killer and CD56+ T cells in vivo","volume":"111","author":"Guia","year":"2008","journal-title":"Blood"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e953410","DOI":"10.4161\/21624011.2014.953410","article-title":"Stress-related and homeostatic cytokines regulate V\u03b39V\u03b42 T-cell surveillance of mevalonate metabolism","volume":"3","author":"Gruenbacher","year":"2014","journal-title":"Oncoimmunology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1365-2567.2003.01575.x","article-title":"Functional and Vbeta repertoire characterization of human CD8+ T-cell subsets with natural killer cell markers, CD56+ CD57\u2212 T cells, CD56+ CD57+ T cells and CD56\u2212 CD57+ T cells","volume":"108","author":"Takayama","year":"2003","journal-title":"Immunology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/intimm\/dxn132","article-title":"IL-23 modulates CD56+\/CD3- NK cell and CD56+\/CD3+ NK-like T cell function differentially from IL-12","volume":"21","year":"2009","journal-title":"Int. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/eji.200535387","article-title":"TCR-independent cytokine stimulation induces non-MHC-restricted T cell activity and is negatively regulated by HLA class I","volume":"36","author":"Simm","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.healun.2013.07.017","article-title":"Targeting peripheral blood pro-inflammatory CD28null T cells and natural killer T-like cells by inhibiting CD137 expression: Possible relevance to treatment of bronchiolitis obliterans syndrome","volume":"32","author":"Hodge","year":"2013","journal-title":"J. Heart Lung Transplant."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12979-022-00274-z","article-title":"NKT-like (CD3\u2009+\u2009CD56+) cells differ from T cells in expression level of cellular protective proteins and sensitivity to stimulation in the process of ageing","volume":"19","author":"Kaszubowska","year":"2022","journal-title":"Immun. Ageing"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.clim.2016.09.004","article-title":"The magnitude of cytokine production by stimulated CD56+ cells is associated with early stages of systemic sclerosis","volume":"173","author":"Cossu","year":"2016","journal-title":"Clin. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.humimm.2006.08.292","article-title":"Activation-induced expression of CD56 by T cells is associated with a reprogramming of cytolytic activity and cytokine secretion profile in vitro","volume":"67","author":"Doherty","year":"2006","journal-title":"Hum. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cyto.2015.01.011","article-title":"Leishmania donovani skews the CD56+ Natural Killer T cell response during human visceral leishmaniasis","volume":"73","author":"Kumari","year":"2015","journal-title":"Cytokine"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1096\/fj.11-188979","article-title":"Virus stimulation of human mast cells results in the recruitment of CD56\u207a T cells by a mechanism dependent on CCR5 ligands","volume":"26","author":"McAlpine","year":"2012","journal-title":"FASEB J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1189\/jlb.0312146","article-title":"CD56+ T cells inhibit HIV-1 infection of macrophages","volume":"92","author":"Hou","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1182\/blood-2004-04-1537","article-title":"CD1d-unrestricted human NKT cells release chemokines upon Fas engagement","volume":"105","author":"Giroux","year":"2005","journal-title":"Blood"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"98","DOI":"10.55563\/clinexprheumatol\/uzzz6d","article-title":"Aberrant distribution of CD3+CD56+ NKT-like cells in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"39","author":"Zhao","year":"2021","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Poonia, B., and Pauza, C.D. (2014). Levels of CD56+TIM-3- effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088884"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.imbio.2010.09.012","article-title":"IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion","volume":"216","author":"Correia","year":"2011","journal-title":"Immunobiology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.aam8825","article-title":"Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells","volume":"359","author":"Ramsuran","year":"2018","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-6150-1-2","article-title":"The orthology of HLA-E and H2-Qa1 is hidden by their concerted evolution with other MHC class I molecules","volume":"1","author":"Joly","year":"2006","journal-title":"Biol. Direct."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35869","article-title":"HLA-E binds to natural killer cell receptors CD94\/NKG2A, B and C","volume":"391","author":"Braud","year":"1998","journal-title":"Nature"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1084\/jem.188.10.1841","article-title":"Mouse CD94\/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)","volume":"188","author":"Vance","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1146\/annurev.immunol.20.100301.064812","article-title":"Structure and function of natural killer cell receptors: Multiple molecular solutions to self, nonself discrimination","volume":"20","author":"Natarajan","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.cell.2018.10.028","article-title":"NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines","volume":"175","author":"Borst","year":"2018","journal-title":"Cell"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4049\/jimmunol.152.2.388","article-title":"Characterization and function of the NKR-P1dim\/T cell receptor-alpha beta+ subset of rat T cells","volume":"152","author":"Kaufman","year":"1994","journal-title":"J. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1182\/blood-2003-06-2125","article-title":"Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells","volume":"103","author":"Verneris","year":"2004","journal-title":"Blood"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.4049\/jimmunol.175.9.6133","article-title":"CD8brightCD56+ T cells are cytotoxic effectors in patients with active Behcet\u2019s uveitis","volume":"175","author":"Ahn","year":"2005","journal-title":"J. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"14124","DOI":"10.1038\/srep14124","article-title":"CD8+NKT-like cells regulate the immune response by killing antigen-bearing DCs","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00262-019-02363-3","article-title":"Mouse CD8+NKT-like cells exert dual cytotoxicity against mouse tumor cells and myeloid-derived suppressor cells","volume":"68","author":"Li","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.humimm.2021.06.001","article-title":"Human CD3+CD56+NKT-like cells express a range of complement receptors and C3 activation has negative effects on these cell activity and effector function","volume":"82","author":"Min","year":"2021","journal-title":"Hum. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/path.1028","article-title":"Fas receptor-mediated apoptosis: A clinical application?","volume":"196","author":"Timmer","year":"2002","journal-title":"J. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s002620000111","article-title":"Resistance of ex vivo expanded CD3+CD56+ T cells to Fas-mediated apoptosis","volume":"49","author":"Verneris","year":"2000","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1158\/1078-0432.CCR-07-4912","article-title":"Isopentenyl pyrophosphate-activated CD56+ \u03b3\u03b4 T lymphocytes display potent antitumor activity toward human squamous cell carcinoma","volume":"14","author":"Alexander","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1183\/09031936.05.00030805","article-title":"Characterisation of natural killer cells and CD56+ T-cells in sarcoidosis patients","volume":"26","author":"Katchar","year":"2005","journal-title":"Eur. Respir. J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1378\/chest.07-0128","article-title":"Expansion of pulmonary CD8+CD56+ natural killer T-cells in hypersensitivity pneumonitis","volume":"132","author":"Korosec","year":"2007","journal-title":"Chest"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/resp.12305","article-title":"Bronchoalveolar lavage fluid and blood natural killer and natural killer T-like cells in cryptogenic organizing pneumonia","volume":"19","author":"Papakosta","year":"2014","journal-title":"Respirology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1465-9921-10-53","article-title":"Altered effector function of peripheral cytotoxic cells in COPD","volume":"10","author":"Urbanowicz","year":"2009","journal-title":"Respir. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1465-9921-11-76","article-title":"Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients","volume":"11","author":"Urbanowicz","year":"2010","journal-title":"Respir. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2249.2004.02536.x","article-title":"The number of CD8+ T cells and NKT cells increases in the aqueous humor of patients with Beh\u00e7et\u2019s uveitis","volume":"137","author":"Yu","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.imlet.2014.03.013","article-title":"A possible role for NKT-like cells in patients with chronic hepatitis B during telbivudine treatment","volume":"160","author":"Diao","year":"2014","journal-title":"Immunol. Lett."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1600-0463.2005.apm_191.x","article-title":"Profiles of NK, NKT cell activation and cytokine production following vaccination against hepatitis B","volume":"113","author":"Albarran","year":"2005","journal-title":"APMIS"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1365-2893.2008.01036.x","article-title":"Alterations in natural killer cells and natural killer T cells during acute viral hepatitis E","volume":"15","author":"Srivastava","year":"2008","journal-title":"J. Viral. Hepat."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00430-014-0338-1","article-title":"Increased expressions of NKp44, NKp46 on NK\/NKT-like cells are associated with impaired cytolytic function in self-limiting hepatitis E infection","volume":"203","author":"Das","year":"2014","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"9292","DOI":"10.1128\/JVI.00834-07","article-title":"Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection","volume":"81","author":"Castelblanco","year":"2007","journal-title":"J. Virol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Chu, P.S., Ebinuma, H., Nakamoto, N., Sugiyama, K., Usui, S., Wakayama, Y., Taniki, N., Yamaguchi, A., Shiba, S., and Yamagishi, Y. (2015). Genotype-Associated Differential NKG2D Expression on CD56+CD3+ Lymphocytes Predicts Response to Pegylated-Interferon\/Ribavirin Therapy in Chronic Hepatitis C. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125664"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0168-8278(02)00072-7","article-title":"Decrease in hepatic CD56+ T cells and V alpha 24+ natural killer T cells in chronic hepatitis C viral infection","volume":"37","author":"Deignan","year":"2002","journal-title":"J. Hepatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"863625","DOI":"10.1155\/2014\/863625","article-title":"The function of CD3+CD56+ NKT-like cells in HIV-infected individuals","volume":"2014","author":"Jiang","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3389\/fmicb.2015.00895","article-title":"Phenotypic and functional analyses of NK and NKT-like populations during the early stages of chikungunya infection","volume":"6","author":"Thanapati","year":"2015","journal-title":"Front Microbiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tube.2014.09.004","article-title":"Increased percentage of IFN-\u03b3 producing CD56+CD3+ cells in active tuberculosis patients upon CFP-10 stimulation of peripheral mononuclear cells","volume":"94","author":"Rojas","year":"2014","journal-title":"Tuberculosis"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00005-017-0500-8","article-title":"NK and NKT-Like Cells in Patients with Recurrent Furunculosis","volume":"66","author":"Nowicka","year":"2018","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Cunha, C.F., Ferraz-Nogueira, R., Costa, V.F.A., and Pimentel, M.I.F. (2020). Chometon TQ, Lyra MR, Schubach AO, Da-Cruz AM, Bertho AL. Contribution of Leishmania braziliensis antigen-specific CD4+ T, CD8+ T, NK and CD3+CD56+NKT cells in the immunopathogenesis of cutaneous leishmaniasis patients: Cytotoxic, activation and exhaustion profiles. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0229400"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1002\/eji.200425929","article-title":"Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells","volume":"35","author":"Borzychowski","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/1933719118766261","article-title":"Diminished Frequency of Menstrual and Peripheral Blood NKT-Like Cells in Patients With Unexplained Recurrent Spontaneous Abortion and Infertile Women","volume":"26","author":"Hosseini","year":"2019","journal-title":"Reprod. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jri.2012.12.006","article-title":"High circulating CD3+CD56+CD16+ natural killer-like T cell levels predict a better IVF treatment outcome","volume":"97","author":"Zhou","year":"2013","journal-title":"J. Reprod. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1600-0897.2007.00529.x","article-title":"Decline in number of elevated blood CD3+ CD56+ NKT cells in response to intravenous immunoglobulin treatment correlates with successful pregnancy","volume":"58","author":"Peralta","year":"2007","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jri.2009.05.005","article-title":"Altered distribution of NK and NKT cells in follicular fluid is associated with IVF outcome","volume":"82","author":"Madar","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"596489","DOI":"10.3389\/fimmu.2020.596489","article-title":"Gamma\/Delta T Cells in the Course of Healthy Human Pregnancy: Cytotoxic Potential and the Tendency of CD8 Expression Make CD56+ \u03b3\u03b4T Cells a Unique Lymphocyte Subset","volume":"11","author":"Barakonyi","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jri.2017.09.008","article-title":"Characteristics of peripheral blood NK and NKT-like cells in euthyroid and subclinical hypothyroid women with thyroid autoimmunity experiencing reproductive failure","volume":"124","author":"Miko","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"799560","DOI":"10.3389\/fcell.2021.799560","article-title":"Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients","volume":"9","author":"Hu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.trim.2011.05.006","article-title":"Distribution of intrahepatic T, NK and CD3+CD56+NKT cells alters after liver transplantation: Shift from innate to adaptive immunity?","volume":"25","author":"Werner","year":"2011","journal-title":"Transpl. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1097\/TP.0000000000001592","article-title":"BOS Is Associated With Increased Cytotoxic Proinflammatory CD8 T, NKT-Like, and NK Cells in the Small Airways","volume":"101","author":"Hodge","year":"2017","journal-title":"Transplantation"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/resp.12933","article-title":"Histone deacetylase 2 is decreased in peripheral blood pro-inflammatory CD8+ T and NKT-like lymphocytes following lung transplant","volume":"22","author":"Hodge","year":"2017","journal-title":"Respirology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1097\/TP.0000000000002817","article-title":"BOS Is Associated With Decreased SIRT1 in Peripheral Blood Proinflammatory T, NK, and NKT-like Lymphocytes","volume":"103","author":"Hodge","year":"2019","journal-title":"Transplantation"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2249.1999.01018.x","article-title":"Natural killer (NK) T cells are significantly decreased in the peripheral blood of patients with rheumatoid arthritis (RA)","volume":"118","author":"Yanagihara","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2016.12.001","article-title":"CD3+CD56+ natural killer T cell activity in children with different forms of juvenile idiopathic arthritis and the influence of etanercept treatment on polyarticular subgroup","volume":"176","author":"Zhou","year":"2017","journal-title":"Clin. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12016-015-8505-8","article-title":"T and NK Cell Phenotypic Abnormalities in Systemic Sclerosis: A Cohort Study and a Comprehensive Literature Review","volume":"49","author":"Almeida","year":"2015","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4236562","DOI":"10.1155\/2019\/4236562","article-title":"Cytotoxic Function and Cytokine Production of Natural Killer Cells and Natural Killer T-Like Cells in Systemic Lupus Erythematosis Regulation with Interleukin-15","volume":"2019","author":"Lin","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s10067-021-06011-z","article-title":"Diminished natural killer T-like cells correlates with aggravated primary Sj\u00f6gren\u2019s syndrome","volume":"41","author":"Zhou","year":"2022","journal-title":"Clin. Rheumatol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"20587384211051982","DOI":"10.1177\/20587384211051982","article-title":"Enriched CD45RA-CD62L+ central memory T and decreased CD3+CD56+ natural killer T lymphocyte subsets in the rectum of ulcerative colitis patients","volume":"36","author":"Iwamuro","year":"2022","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/s12967-021-03055-2","article-title":"Increased Tc17 cel levels and imbalance of na\u00efve\/effector immune response in Parkinson\u2019s disease patients in a two-year follow-up: A case control study","volume":"19","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12974-019-1482-8","article-title":"Plasma VCAM1 levels correlate with disease severity in Parkinson\u2019s disease","volume":"16","author":"Perner","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.3233\/JAD-161304","article-title":"Alterations in the Peripheral Immune System in Dementia","volume":"58","author":"Busse","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"100218","DOI":"10.1016\/j.bbih.2021.100218","article-title":"Dementia-associated changes of immune cell composition within the cerebrospinal fluid","volume":"14","author":"Busse","year":"2021","journal-title":"Brain Behav. Immun. Health"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"768229","DOI":"10.3389\/fnagi.2021.768229","article-title":"Application of Artificial Intelligence Modeling Technology Based on Fluid Biopsy to Diagnose Alzheimer\u2019s Disease","volume":"13","author":"Sh","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s13578-022-00897-1","article-title":"A change of PD-1\/PD-L1 expression on peripheral T cell subsets correlates with the diferente stages of Alzheimer\u2019s Disease","volume":"12","author":"Wu","year":"2022","journal-title":"Cell Biosci."},{"key":"ref_153","first-page":"3128758","article-title":"Immunosenescence of Natural Killer Cells, Inflammation, and Alzheimer\u2019s Disease","volume":"2018","author":"Solana","year":"2018","journal-title":"Int. J. Alzheimers Dis."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Zarobkiewicz, M.K., Morawska, I., Michalski, A., Roli\u0144ski, J., and Bojarska-Junak, A. (2021). NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases-Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179520"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/cei.12580","article-title":"Natural killer cell subsets in cerebrospinal fluid of patients with multiple sclerosis","volume":"180","author":"Alenda","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13223-021-00596-5","article-title":"The frequencies of peripheral blood CD5+CD19+ B cells, CD3-CD16+CD56+ NK, and CD3+CD56+ NKT cells and serum interleukin-10 in patients with multiple sclerosis and neuromyelitis optica spectrum disorder","volume":"18","author":"Khani","year":"2022","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fimmu.2019.00515","article-title":"Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights Into Inflammatory Neuropathies","volume":"10","author":"Heming","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1038\/s41380-020-01008-7","article-title":"Natural killer cells in first-episode psychosis: Na innate immune signature?","volume":"26","author":"Tarantino","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbi.2019.06.037","article-title":"Natural killer cells protect white matter integrity in bipolar disorder","volume":"81","author":"Furlan","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"577475","DOI":"10.1016\/j.jneuroim.2021.577475","article-title":"Interleukin-1\u03b2 in peripheral monocytes is associated with seizure frequency in pediatric drug-resistant epilepsy","volume":"352","author":"Yamanaka","year":"2021","journal-title":"J. NeuroImmunol."},{"key":"ref_161","first-page":"803","article-title":"Natural killer-like T CD3+\/CD16+CD56+ cells in chronic lymphocytic leukemia: Intracellular cytokine expression and relationship with clinical outcome","volume":"24","author":"Hus","year":"2010","journal-title":"Oncol. Rep."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1007\/s12032-012-0262-4","article-title":"Reduced frequency of NKT-like cells in patients with progressive chronic lymphocytic leukemia","volume":"29","author":"Ansaripour","year":"2012","journal-title":"Med. Oncol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.3389\/fimmu.2019.02493","article-title":"NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors","volume":"10","author":"Almeida","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1038\/sj.leu.2403083","article-title":"Expansion of natural killer (NK) and natural killer-like T (NKT)-cell populations derived from patients with B-chronic lymphocytic leukemia (B-CLL): A potential source for cellular immunotherapy","volume":"17","author":"Guven","year":"2003","journal-title":"Leukemia"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Valhondo, I., Hassouneh, F., Lopez-Sejas, N., Pera, A., Sanchez-Correa, B., Guerrero, B., Bergua, J.M., Arcos, M.J., Ba\u00f1as, H., and Casas-Avil\u00e9s, I. (2020). Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia. Cancers, 12.","DOI":"10.3390\/cancers12082171"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1053\/jhep.2000.19362","article-title":"Decrease of CD56+T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma","volume":"32","author":"Kawarabayashi","year":"2000","journal-title":"Hepatology"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00262-008-0603-5","article-title":"The immunosuppressive tumor microenvironment in hepatocellular carcinoma","volume":"58","author":"Pang","year":"2009","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1600-0463.2009.02547.x","article-title":"Decrease in intrahepatic CD56+ lymphocytes in gastric and colorectal cancer patients with liver metastases","volume":"117","author":"Gulubova","year":"2009","journal-title":"APMIS"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2002068","DOI":"10.1080\/2162402X.2021.2002068","article-title":"PD-1 blockade improves the anti-tumor potency of exhausted CD3+CD56+ NKT-like cells in patients with primary hepatocellular carcinoma","volume":"10","author":"Tao","year":"2021","journal-title":"Oncoimmunology"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Bochem, J., Zelba, H., Amaral, T., Spreuer, J., Soffel, D., Eigentler, T., Wagner, N.B., Uslu, U., Terheyden, P., and Meier, F. (2019). Peripheral PD-1+CD56+ T-cell frequencies correlate with outcome in stage IV melanoma under PD-1 blockade. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221301"},{"key":"ref_171","first-page":"6","article-title":"Decline in peripheral blood NKG2D+CD3+CD56+ NKT cells in metastatic colorectal cancer patients","volume":"119","author":"Gharagozloo","year":"2018","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00262-019-02343-7","article-title":"Kuppen PJK. Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: The peripheral blood immune cell profile","volume":"68","author":"Krijgsman","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"55222","DOI":"10.18632\/oncotarget.10484","article-title":"Altered phenotypic and functional characteristics of CD3+CD56+ NKT-like cells in human gastric cancer","volume":"7","author":"Peng","year":"2016","journal-title":"Oncotarget"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"558169","DOI":"10.3389\/fimmu.2020.558169","article-title":"Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma","volume":"11","author":"Lundgren","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/intimm\/dxr122","article-title":"Increased numbers but functional defects of CD56+CD3+ cells in lung cancer","volume":"24","author":"Marshall","year":"2012","journal-title":"Int. Immunol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.exphem.2009.07.009","article-title":"Characterization of natural killer and natural killer-like T cells derived from ex vivo expanded and activated cord blood mononuclear cells: Implications for adoptive cellular immunotherapy","volume":"37","author":"Ayello","year":"2009","journal-title":"Exp. Hematol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00432-014-1864-3","article-title":"Cytokine-induced Killer (CIK) cells in cancer immunotherapy: Report of the international registry on CIK cells (IRCC)","volume":"141","author":"Schmeel","year":"2015","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Introna, M., and Correnti, F. (2018). Innovative Clinical Perspectives for CIK Cells in Cancer Patients. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020358"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"9291","DOI":"10.1002\/jcp.29827","article-title":"Ten-year update of the international registry on cytokine-induced killer cells in cancer immunotherapy","volume":"235","author":"Zhang","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ymthe.2021.10.011","article-title":"IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors","volume":"30","author":"Hombach","year":"2022","journal-title":"Mol. Ther."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"581468","DOI":"10.3389\/fimmu.2020.581468","article-title":"ERBB2-CAR-Engineered Cytokine- Induced Killer Cells Exhibit Both CAR-Mediated and Innate Immunity Against High-Risk Rhabdomyosarcoma","volume":"11","author":"Merker","year":"2020","journal-title":"Front Immunol."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Dehno, M.N., Li, Y., Weiher, H., and Schmidt-Wolf, I.G.H. (2020). Increase in Efficacy of Checkpoint Inhibition by Cytokine-Induced-Killer Cells as a Combination Immunotherapy for Renal Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21093078"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.atherosclerosis.2012.07.033","article-title":"Persistent accumulation of interferon-\u03b3-producing CD8+CD56+ T cells in blood from patients with coronary artery disease","volume":"224","author":"Backteman","year":"2012","journal-title":"Atherosclerosis."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1055\/s-0033-1363233","article-title":"Circulating CD3+56+ cell subset in pre-diabetes","volume":"122","author":"Dworacka","year":"2014","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.molimm.2018.12.008","article-title":"IL-17 production by NKG2D-expressing CD56+ T cells in type 2 diabetes","volume":"106","author":"Phoksawat","year":"2019","journal-title":"Mol. Immunol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/3\/2743\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:20:41Z","timestamp":1760120441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/3\/2743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":185,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ijms24032743"],"URL":"https:\/\/doi.org\/10.3390\/ijms24032743","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]}}}