{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:22:34Z","timestamp":1761218554424,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","doi-asserted-by":"publisher","award":["UIDB\/QUI\/00313\/2020","RP\/CPS\/2022\/003"],"award-info":[{"award-number":["UIDB\/QUI\/00313\/2020","RP\/CPS\/2022\/003"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic DKRVO","award":["UIDB\/QUI\/00313\/2020","RP\/CPS\/2022\/003"],"award-info":[{"award-number":["UIDB\/QUI\/00313\/2020","RP\/CPS\/2022\/003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Knowledge of mass transport parameters, diffusion, and viscosity of hyaluronic acid (HA) in the presence of cyclodextrins is of considerable importance for areas such as food packaging and drug delivery, among others. Despite a number of studies investigating the functionalization of HA or the corresponding sodium salt by cyclodextrins, only a few studies have reported the effect of cyclodextrins on the mass transport of HA in the presence of these oligosaccharides. Here, we report the tracer binary and ternary interdiffusion coefficients of sodium hyaluronate (NaHy) in water and aqueous \u03b2-cyclodextrin solutions. The diffusion behavior of sodium hyaluronate was dependent on the reduced viscosity of NaHy, which, in turn, presented a concave dependence on concentration, with a minimum at approximately 2.5 g dm\u22123. The significant decrease in the limiting diffusion coefficient of NaHy (at most 45%) at NaHy concentrations below 1 g dm\u22123 in the presence of \u03b2-cyclodextrin, taking water as the reference, allowed us to conclude that NaHy strongly interacted with the cyclodextrin.<\/jats:p>","DOI":"10.3390\/ijms24032889","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T05:44:45Z","timestamp":1675316685000},"page":"2889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interactions between Sodium Hyaluronate and \u03b2-Cyclodextrin as Seen by Transport Properties"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-178X","authenticated-orcid":false,"given":"Lenka","family":"Musilov\u00e1","sequence":"first","affiliation":[{"name":"Department of Physics and Materials Engineering, Faculty of Technology, Thomas Bata University in Zl\u00edn, Vavre\u010dkova 275, 760 01 Zl\u00edn, Czech Republic"},{"name":"Centre of Polymer Systems, Thomas Bata University in Zl\u00edn, t\u0159. Tom\u00e1\u0161e Bati 5678, 760 01 Zl\u00edn, Czech Republic"}]},{"given":"Ale\u0161","family":"Mr\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"Department of Physics and Materials Engineering, Faculty of Technology, Thomas Bata University in Zl\u00edn, Vavre\u010dkova 275, 760 01 Zl\u00edn, Czech Republic"},{"name":"Centre of Polymer Systems, Thomas Bata University in Zl\u00edn, t\u0159. Tom\u00e1\u0161e Bati 5678, 760 01 Zl\u00edn, Czech Republic"}]},{"given":"Eduarda F. G.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Centro de Qu\u00edmica, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-7686","authenticated-orcid":false,"given":"Artur J. M.","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Centro de Qu\u00edmica, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-0028","authenticated-orcid":false,"given":"Ana M. T. D. P. V.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Centro de Qu\u00edmica, University of Coimbra, 3004-535 Coimbra, Portugal"},{"name":"Faculdade de Farm\u00e1cia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3005-1963","authenticated-orcid":false,"given":"Ana C. F.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Centro de Qu\u00edmica, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-3999","authenticated-orcid":false,"given":"Miguel A.","family":"Esteso","sequence":"additional","affiliation":[{"name":"U.D. Qu\u00edmica F\u00edsica, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares (Madrid), Spain"},{"name":"Faculty of Health Sciences, Universidad Cat\u00f3lica de \u00c1vila, Calle Los Canteros s\/n, 05005 \u00c1vila, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/1523-1747.ep12319412","article-title":"Developmentally Programmed Expression of Hyaluronan in Human Skin and its Appendages","volume":"109","author":"Tammi","year":"1997","journal-title":"J. Investig. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.addr.2015.10.017","article-title":"Hyaluronan as a therapeutic target in human diseases","volume":"97","author":"Liang","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Di Mola, A., Landi, M.R., Massa, A., D\u2019Amora, U., and Guarino, V. (2022). 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