{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:01:05Z","timestamp":1772503265853,"version":"3.50.1"},"reference-count":132,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Andalusian Ministry of Economy, Knowledge, Business, and University, Government of Andalusia, Spain","doi-asserted-by":"publisher","award":["US-1263458"],"award-info":[{"award-number":["US-1263458"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Andalusian Ministry of Economy, Knowledge, Business, and University, Government of Andalusia, Spain","doi-asserted-by":"publisher","award":["2021\/CTS-1074"],"award-info":[{"award-number":["2021\/CTS-1074"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Andalusian Government","doi-asserted-by":"publisher","award":["US-1263458"],"award-info":[{"award-number":["US-1263458"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Andalusian Government","doi-asserted-by":"publisher","award":["2021\/CTS-1074"],"award-info":[{"award-number":["2021\/CTS-1074"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common form of dementia. The physiopathology of AD is well described by the presence of two neuropathological features: amyloid plaques and tau neurofibrillary tangles. In the last decade, neuroinflammation and cellular stress have gained importance as key factors in the development and pathology of AD. Chronic cellular stress occurs in degenerating neurons. Stress Granules (SGs) are nonmembranous organelles formed as a response to stress, with a protective role; however, SGs have been noted to turn into pathological and neurotoxic features when stress is chronic, and they are related to an increased tau aggregation. On the other hand, correct lipid metabolism is essential to good function of the brain; apolipoproteins are highly associated with risk of AD, and impaired cholesterol efflux and lipid transport are associated with an increased risk of AD. In this review, we provide an insight into the relationship between cellular stress, SGs, protein aggregation, and lipid metabolism in AD.<\/jats:p>","DOI":"10.3390\/ijms24032944","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T02:35:10Z","timestamp":1675391710000},"page":"2944","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lipoprotein Metabolism, Protein Aggregation, and Alzheimer\u2019s Disease: A Literature Review"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4003-4400","authenticated-orcid":false,"given":"Elena","family":"Grao-Cruces","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, 41009 Sevilla, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-405X","authenticated-orcid":false,"given":"Carmen M.","family":"Claro-Cala","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pediatrics, and Radiology, School of Medicine, University of Seville, 41009 Sevilla, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-3192","authenticated-orcid":false,"given":"Sergio","family":"Montserrat-de la Paz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, 41009 Sevilla, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-5292","authenticated-orcid":false,"given":"Clevio","family":"Nobrega","sequence":"additional","affiliation":[{"name":"ABC-RI\u2014Algarve Biomedical Center Research Institute, Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/alz.12362","article-title":"Population Estimate of People with Clinical Alzheimer\u2019s Disease and Mild Cognitive Impairment in the United States (2020\u20132060)","volume":"17","author":"Rajan","year":"2021","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association (2021). 2021 Alzheimer\u2019s Disease Facts and Figures. 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