{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:56:57Z","timestamp":1767193017202,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coimbra Chemistry Centre","award":["UID\/QUI\/UI0313\/2020","INV-2020-99-2009","IHU-007-2022","Doctorado Nacional-6172"],"award-info":[{"award-number":["UID\/QUI\/UI0313\/2020","INV-2020-99-2009","IHU-007-2022","Doctorado Nacional-6172"]}]},{"DOI":"10.13039\/501100006070","name":"Faculty of Science and Vicerrectoria de Investigaciones at the Universidad de los Andes, Colombia","doi-asserted-by":"publisher","award":["UID\/QUI\/UI0313\/2020","INV-2020-99-2009","IHU-007-2022","Doctorado Nacional-6172"],"award-info":[{"award-number":["UID\/QUI\/UI0313\/2020","INV-2020-99-2009","IHU-007-2022","Doctorado Nacional-6172"]}],"id":[{"id":"10.13039\/501100006070","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty of Sciences and Humanities and the Comit\u00e9 de Ciencia y Tecnolog\u00eda at the Fundaci\u00f3n Universidad de Am\u00e9rica","award":["UID\/QUI\/UI0313\/2020","INV-2020-99-2009","IHU-007-2022","Doctorado Nacional-6172"],"award-info":[{"award-number":["UID\/QUI\/UI0313\/2020","INV-2020-99-2009","IHU-007-2022","Doctorado Nacional-6172"]}]},{"name":"doctoral fellowship","award":["UID\/QUI\/UI0313\/2020","INV-2020-99-2009","IHU-007-2022","Doctorado Nacional-6172"],"award-info":[{"award-number":["UID\/QUI\/UI0313\/2020","INV-2020-99-2009","IHU-007-2022","Doctorado Nacional-6172"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The interaction between sodium salicylate (NaSal) and the two macrocycles 5,11,17,23-tetrakissulfonatomethylene-2,8,14,20-tetra(ethyl)resorcinarene (Na4EtRA) and \u03b2-cyclodextrin (\u03b2-CD) has been studied by the determination of ternary mutual diffusion coefficients, and spectroscopic and computational techniques. The results obtained by the Job method suggest that the complex formation is given in a 1:1 ratio for all systems. The mutual diffusion coefficients and the computational experiments have shown that the \u03b2-CD-NaSal system presents an inclusion process, whereas the Na4EtRA-NaSal system forms an outer-side complex. This fact is also in line with the results obtained from the computational experiments, where the calculated solvation free energy has been found to be more negative for the Na4EtRA-NaSal complex because of the partial entry of the drug inside the Na4EtRA cavity.<\/jats:p>","DOI":"10.3390\/ijms24043921","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:12:26Z","timestamp":1676437946000},"page":"3921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Interactions of Sodium Salicylate with \u03b2-Cyclodextrin and an Anionic Resorcin[4]arene: Mutual Diffusion Coefficients and Computational Study"],"prefix":"10.3390","volume":"24","author":[{"given":"Diana M.","family":"Galindres","sequence":"first","affiliation":[{"name":"Grupo de Fisicoqu\u00edmica y An\u00e1lisis Matem\u00e1tico (Physchemath), Facultad de Ciencias y Humanidades, Universidad de Am\u00e9rica, Avda Circunvalar No. 20-53, Bogot\u00e1 110321, Colombia"}]},{"given":"Nicol\u00e1s","family":"Espitia-Galindo","sequence":"additional","affiliation":[{"name":"Grupo de Termodin\u00e1mica de Soluciones, Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de los Andes, Cra 1 No. 18A-12, Bogot\u00e1 111711, Colombia"},{"name":"Molecular Electronic Structure Group, Department of Chemistry, Universidad de los Andes, Carrera 1 No. 18A-10, Bogot\u00e1 111711, Colombia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-7686","authenticated-orcid":false,"given":"Artur J. 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