{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:03:21Z","timestamp":1772863401980,"version":"3.50.1"},"reference-count":10,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Liposomes have been known of for about 60 years, since they were discovered by A [...]<\/jats:p>","DOI":"10.3390\/ijms24054343","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T03:32:17Z","timestamp":1677036737000},"page":"4343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Liposomes: The Brave Old World"],"prefix":"10.3390","volume":"24","author":[{"given":"Carla M.","family":"Matos","sequence":"first","affiliation":[{"name":"FP-I3ID (Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento Fernando Pessoa), FP-BHS (Biomedical and Health Sciences), Universidade Fernando Pessoa, Pra\u00e7a 9 de Abril, 349, 4249-004 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0022-2836(65)80094-8","article-title":"The action of steroids and streptolysin S on the permeability of phospholipid structures to cations","volume":"13","author":"Bangham","year":"1965","journal-title":"J. Mol. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/08982104.2012.742539","article-title":"Correlation between octanol\/water and liposome\/water distribution coefficients and drug absorption of a set of pharmacologically active compounds","volume":"23","author":"Esteves","year":"2013","journal-title":"J. Liposome Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.2174\/0929867326666190227233321","article-title":"Non-Steroidal Anti-Inflammatory Drugs Loaded Liposomes for Topical Treatment of Inflammatory and Degenerative Conditions","volume":"27","author":"Matos","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/1520-6017(200103)90:3<298::AID-JPS5>3.0.CO;2-1","article-title":"Effect of liposomes on the rate of alkaline hydrolysis of indomethacin and acemetacin","volume":"90","author":"Matos","year":"2001","journal-title":"J. Pharm. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"122097","DOI":"10.1016\/j.jchromb.2020.122097","article-title":"Development of an immobilized liposome chromatography method for screening and characterizing \u03b1-glucosidase-binding compounds","volume":"1148","author":"Hou","year":"2020","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Fliedel, L., Alhareth, K., Seguin, J., El-Khashab, M., Chissey, A., Mignet, N., Fournier, T., and Andrieux, K. (2022). Influence of Liposomes\u2019 and Lipoplexes\u2019 Physicochemical Characteristics on Their Uptake Rate and Mechanisms by the Placenta. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116299"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zimmermann, J., Schmidt, S.T., Trebbien, R., Cox, R.J., Zhou, F., Follmann, F., Pedersen, G.K., and Christensen, D. (2022). A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031850"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kobanenko, M.K., Tretiakova, D.S., Shchegravina, E.S., Antipova, N.V., Boldyrev, I.A., Fedorov, A.Y., Vodovozova, E.L., and Onishchenko, N.R. (2022). Liposomal Formulation of a PLA2-Sensitive Phospholipid\u2013Allocolchicinoid Conjugate: Stability and Activity Studies In Vitro. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031034"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Skupin-Mrugalska, P., Elvang, P.A., and Brandl, M. (2021). Application of Asymmetrical Flow Field-Flow Fractionation for Characterizing the Size and Drug Release Kinetics of Theranostic Lipid Nanovesicles. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910456"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Souto, E.B., Macedo, A.S., Dias-Ferreira, J., Cano, A., Zieli\u0144ska, A., and Matos, C.M. (2021). Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharmaceutical Ingredients (APIs). Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189743"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/4343\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:39:00Z","timestamp":1760121540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/4343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijms24054343"],"URL":"https:\/\/doi.org\/10.3390\/ijms24054343","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,22]]}}}