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However, the placement of the implant is sometimes associated with bacterial infection leading to its loss. In this work, we intend to solve this problem through the development of a biomaterial for implant coatings based on 45S5 Bioglass\u00ae modified with different amounts of niobium pentoxide (Nb2O5). The structural feature of the glasses, assessed by XRD and FTIR, did not change in spite of Nb2O5 incorporation. The Raman spectra reveal the Nb2O5 incorporation related to the appearance of NbO4 and NbO6 structural units. Since the electrical characteristics of these biomaterials influence their osseointegration ability, AC and DC electrical conductivity were studied by impedance spectroscopy, in the frequency range of 102\u2013106 Hz and temperature range of 200\u2013400 K. The cytotoxicity of glasses was evaluated using the osteosarcoma Saos-2 cells line. The in vitro bioactivity studies and the antibacterial tests against Gram-positive and Gram-negative bacteria revealed that the samples loaded with 2 mol% Nb2O5 had the highest bioactivity and greatest antibacterial effect. Overall, the results showed that the modified 45S5 bioactive glasses can be used as an antibacterial coating material for implants, with high bioactivity, being also non-cytotoxic to mammalian cells.<\/jats:p>","DOI":"10.3390\/ijms24065244","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T02:30:33Z","timestamp":1678415433000},"page":"5244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9007-2221","authenticated-orcid":false,"given":"Imen","family":"Hammami","sequence":"first","affiliation":[{"name":"I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-3735","authenticated-orcid":false,"given":"S\u00edlvia Rodrigues","family":"Gavinho","sequence":"additional","affiliation":[{"name":"I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5707-9157","authenticated-orcid":false,"given":"Ana Sofia","family":"P\u00e1dua","sequence":"additional","affiliation":[{"name":"Physics Department and CENIMAT-I3N, NOVA School of Science and Technology, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9258-4899","authenticated-orcid":false,"given":"Maria do Carmo","family":"Lan\u00e7a","sequence":"additional","affiliation":[{"name":"Materials Science Department and CENIMAT-I3N, NOVA School of Science and Technology, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-6545","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Borges","sequence":"additional","affiliation":[{"name":"Materials Science Department and CENIMAT-I3N, NOVA School of Science and Technology, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-4272","authenticated-orcid":false,"given":"Jorge Carvalho","family":"Silva","sequence":"additional","affiliation":[{"name":"Physics Department and CENIMAT-I3N, NOVA School of Science and Technology, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6665-7994","authenticated-orcid":false,"given":"Isabel","family":"S\u00e1-Nogueira","sequence":"additional","affiliation":[{"name":"UCIBIO, Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-9495","authenticated-orcid":false,"given":"Suresh Kumar","family":"Jakka","sequence":"additional","affiliation":[{"name":"I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-9507","authenticated-orcid":false,"given":"Manuel Pedro Fernandes","family":"Gra\u00e7a","sequence":"additional","affiliation":[{"name":"I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5125\/jkaoms.2014.40.2.50","article-title":"Current trends in dental implants","volume":"40","author":"Gaviria","year":"2014","journal-title":"J. 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